Prospects for the development of epigenetic drugs for CNS conditions
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Title
Prospects for the development of epigenetic drugs for CNS conditions
Authors
Keywords
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 14, Issue 7, Pages 461-474
Publisher
Springer Nature
Online
2015-05-22
DOI
10.1038/nrd4580
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- (2015) Mª Jesús Serramía et al. JOURNAL OF CONTROLLED RELEASE
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- (2014) Johannes Gräff et al. CELL
- Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells
- (2014) Yu Lu et al. Cell Stem Cell
- New and emerging HDAC inhibitors for cancer treatment
- (2014) Alison C. West et al. JOURNAL OF CLINICAL INVESTIGATION
- Clinical development of demethylating agents in hematology
- (2014) Shyamala C. Navada et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer epigenetics drug discovery and development: the challenge of hitting the mark
- (2014) Robert M. Campbell et al. JOURNAL OF CLINICAL INVESTIGATION
- A Double-Blind, Randomized, Placebo-Controlled Clinical Trial ofS-Adenosyl-l-Methionine (SAMe) Versus Escitalopram in Major Depressive Disorder
- (2014) David Mischoulon et al. JOURNAL OF CLINICAL PSYCHIATRY
- Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory
- (2014) J. Zhang et al. JOURNAL OF NEUROSCIENCE
- A Myristoylated Cell-Penetrating Peptide Bearing a Transferrin Receptor-Targeting Sequence for Neuro-Targeted siRNA Delivery
- (2014) Pilju Youn et al. MOLECULAR PHARMACEUTICS
- Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications
- (2014) Bryan R Meade et al. NATURE BIOTECHNOLOGY
- Circadian behavior is light-reprogrammed by plastic DNA methylation
- (2014) Abdelhalim Azzi et al. NATURE NEUROSCIENCE
- DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
- (2014) Claire Guillemin et al. PLoS One
- Off-Label Use of Sodium Valproate for Schizophrenia
- (2014) Einav Horowitz et al. PLoS One
- Association of Childhood Chronic Physical Aggression with a DNA Methylation Signature in Adult Human T Cells
- (2014) Nadine Provençal et al. PLoS One
- Advances in epigenome-wide association studies for common diseases
- (2014) Dirk S. Paul et al. TRENDS IN MOLECULAR MEDICINE
- Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder
- (2014) Esther R. Berko et al. PLoS Genetics
- The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes
- (2014) R Massart et al. Translational Psychiatry
- Genome-Wide Methylation Changes in the Brains of Suicide Completers
- (2013) Benoit Labonté et al. AMERICAN JOURNAL OF PSYCHIATRY
- The Potential of HDAC Inhibitors as Cognitive Enhancers
- (2013) Johannes Gräff et al. Annual Review of Pharmacology and Toxicology
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- (2013) Tuncay Baubec et al. CELL
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- (2013) S. Gelfman et al. GENOME RESEARCH
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- (2013) Li Zhu et al. HUMAN MOLECULAR GENETICS
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- (2013) M. J. Morris et al. JOURNAL OF NEUROSCIENCE
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- (2013) Ah Reum LEE et al. JOURNAL OF REPRODUCTION AND DEVELOPMENT
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- (2013) C Ladd-Acosta et al. MOLECULAR PSYCHIATRY
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- (2013) Rahul M. Kohli et al. NATURE
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- (2013) Junjie U Guo et al. NATURE NEUROSCIENCE
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- (2013) Matthew M Dobbin et al. NATURE NEUROSCIENCE
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- (2013) Ziv M. Machnes et al. PLoS One
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- (2013) M. Malvaez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) Amir H. Moarefi et al. JOURNAL OF MOLECULAR BIOLOGY
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- (2011) Patrick O. McGowan et al. PLoS One
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- A meta-analysis of mood stabilizers for Alzheimer’s disease
- (2010) Haibing Xiao et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Histone Methylation Regulates Memory Formation
- (2010) S. Gupta et al. JOURNAL OF NEUROSCIENCE
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- (2010) Courtney A Miller et al. NATURE NEUROSCIENCE
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- Chromatin particle spectrum analysis: a method for comparative chromatin structure analysis using paired-end mode next-generation DNA sequencing
- (2010) N. A. Kent et al. NUCLEIC ACIDS RESEARCH
- Behavioral Signs of Chronic Back Pain in the SPARC-Null Mouse
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- (2010) André Fischer et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- A review of valproate in psychiatric practice
- (2009) Peter M Haddad et al. Expert Opinion on Drug Metabolism & Toxicology
- Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II
- (2009) P. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- HDAC2 negatively regulates memory formation and synaptic plasticity
- (2009) Ji-Song Guan et al. NATURE
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- (2009) Ryan Lister et al. NATURE
- Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
- (2009) Patrick O McGowan et al. NATURE NEUROSCIENCE
- Ethical implications of epigenetics research
- (2009) Mark A. Rothstein et al. NATURE REVIEWS GENETICS
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- (2009) W.M.A. Verhoeven et al. PSYCHOPATHOLOGY
- Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis
- (2009) D. K. Ma et al. SCIENCE
- The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
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- (2009) Jonathan L.C. Lee TRENDS IN NEUROSCIENCES
- Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease: A 1-year, Open-label Pilot Study With an 16-Month Caregiver Extension
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- (2008) C. L. Benn et al. JOURNAL OF NEUROSCIENCE
- S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
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- Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain
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- Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients
- (2007) Mamoru Tochigi et al. BIOLOGICAL PSYCHIATRY
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