Article
Pharmacology & Pharmacy
Zhiyong Liu, Manish Kumar, Sushma Devi, Atul Kabra
Summary: This study investigated the neuroprotective effects of cucurbitacin E (CuE) on neurobehavioral impairments caused by cerebral hypoperfusion. CuE alleviated brain cell death induced by cerebral hypoperfusion and improved memory, sensory, and motor functions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Javeed Ahmad Bhat, Manish Kumar
Summary: This study evaluated the neuroprotective potential of theobromine against cerebral hypoperfusion. The results showed that theobromine could improve neurological deficits, sensorimotor functions, and memory, and attenuate oxidative stress and inflammation in brain tissues. These findings suggest that theobromine may play an important role in improving the pathology of cerebral hypoperfusion.
METABOLIC BRAIN DISEASE
(2022)
Article
Clinical Neurology
Bin Liu, Guifeng Zhao, Ling Jin, Jingping Shi
Summary: The study showed that Nicotinamide (NAM) can improve cognitive function in mice with chronic cerebral hypoperfusion (CCH) and reduce white matter damage and remodeling. Results from various cognitive and behavioral tests demonstrated that mice in the NAM group performed better than those in the CCH group.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Shouhang Yin, Taiyong Bi, Antao Chen, Tobias Egner
Summary: Humans tend to prioritize processing self-related information in working memory, with the ventromedial prefrontal cortex playing a causal role in driving this self-bias. Transcranial direct current stimulation can modulate this self-prioritization effect.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Ana Paula Rodrigues Martini, Eduarda Hoeper, Thales Avila Pedroso, Andrey Vinicios Soares Carvalho, Felipe Kawa Odorcyk, Rafael Bandeira Fabres, Natividade de Sa Couto Pereira, Carlos Alexandre Netto
Summary: This study aimed to investigate the effects of acrobatic training on male and female rats with chronic cerebral hypoperfusion. The results showed that acrobatic training prevented spatial memory impairments caused by chronic cerebral hypoperfusion, especially in female rats. Additionally, acrobatic training promoted neuronal survival, improved mitochondrial function, and influenced the glial scar in a sex-dependent manner.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Vijay Kumar, Sonika Nichenmetla, Harleen Chhabra, Vanteemar S. Sreeraj, Naren P. Rao, Muralidharan Kesavan, Shivarama Varambally, Ganesan Venkatasubramanian, Bangalore N. Gangadhar
Summary: Utilizing fNIRS technology, this study investigated the hemodynamic activity during a working memory task in schizophrenia patients, revealing alterations in the right frontopolar cortex possibly linked to working memory deficits. Furthermore, olanzapine equivalent doses were found to be correlated with brain activity and performance in working memory tasks.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Cell Biology
Li-Jie Yang, Wei Wu, Wan-Rong Jiang, Cheng-Liang Zhu, Zhao -Hui Yao
Summary: Chronic cerebral hypoperfusion (CCH)-mediated cognitive impairment is a global problem. In this study, we found that RasGRF1 expression levels decreased after CCH, while the inhibition of miRNA-323-3p upregulated RasGRF1 expression and improved cognitive impairments such as spatial learning and memory.
Article
Pharmacology & Pharmacy
Yuki Kambe, Thu Nguyen Thi, Kohei Hashiguchi, Yoshimune Sameshima, Akira Yamashita, Takashi Kurihara, Atsuro Miyata
Summary: Studies suggest that PTG in the dorsal hippocampus plays a crucial role in glycogenesis and may contribute to working memory and short-term memory by maintaining the expression of glutamate receptor subunits.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Jing Wu, Lynda El-Hassar, Dibyadeep Datta, Merrilee Thomas, Yalan Zhang, David P. Jenkins, Nicholas J. Deluca, Manavi Chatterjee, Valentin K. Gribkoff, Amy F. T. Arnsten, Leonard K. Kaczmarek
Summary: The ability of monkeys and rats to perform spatial working memory tasks is dependent on the interaction between hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and Slack sodium-activated potassium (KNa) channels in the prefrontal cortex. Activation of HCN channels leads to suppression of neuronal excitability, thus affecting working memory performance.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yan Yu, Jing-Jing Li, Xiao-Qian He, Zi-Ying Lai, Rui Hao, Yu Qi, Dong-Qing Cao, Ming Fu, Hong Ma, Qiu-Chen Xie, Mu Sun, Zhi-Li Huang, Ling-Jing Jin, Hui-hui Sun, Ning Lu, Rui Wang, Wing-Ho Yung, Ying Huang
Summary: This study found that dysfunction of the 5-HT3R affects synaptic plasticity between hippocampal neurons, leading to impairment in spatial memory. This effect is mediated through the CB1R-GABA(A) pathway on the 5-HT3R.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Katarzyna Terejko, Michal A. Michalowski, Anna Dominik, Anna Andrzejczak, Jerzy W. Mozrzymas
Summary: Recent studies have shown that the activation of pLGICs is associated with coordinated subunit twisting in the membrane plane, indicating a crucial role of intersubunit interactions in receptor activation, especially in preactivation and opening processes. The underlying mechanisms of this intersubunit cross-talk outside the top-down pathway remain largely unknown.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Parviz Naderipoor, Mohammad Amani, Ali Abedi, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadati
Summary: The study found that blockade of GABA-A receptors in neonatal rats can affect neurobehavioral phenotypes in adulthood, with higher doses increasing passive avoidance memory and hippocampal BDNF levels, while lower doses impair this memory type and increase PFC BDNF levels. Additionally, drug treatment during the neonatal period increased anxiety and pain sensitivity in a dose-dependent manner. Overall, these results suggest the importance of GABA-A receptors in programming neurobehavioral phenotypes in adult life.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Yang Yang, Sang-Min Lee, Fumiaki Imamura, Krishne Gowda, Shantu Amin, Richard B. Mailman
Summary: This study compared two different D-1 agonists and found that 2-methyldihydrexidine was more effective in enhancing cognition compared to CY208,243, based on its impact on neural activity and cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Annie Lei, Kristen R. Breit, Jennifer D. Thomas
Summary: Alcohol and cannabis can negatively affect fetal development and lead to cognitive impairments. However, the combined effects of prenatal exposure to both substances are not well understood. This study used an animal model to investigate the effects of prenatal exposure to ethanol, THC, or the combination on spatial and working memory.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Yu Sun, Zechun Peng, Xiaofei Wei, Nianhui Zhang, Martin Wallner, Istvan Mody, Carolyn R. Houser
Summary: The decreased expression of the delta subunit of the GABA(A) receptor has been found to be associated with altered modulation of tonic inhibition in dentate granule cells in animal models of epilepsy and other disorders. This study aimed to investigate if viral transfection of delta subunits could restore network excitability in a mouse model of epilepsy. The results showed that transfection of delta subunits increased delta subunit expression, downregulated other GABA(A) receptor subunits, and restored more normal network excitability.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)