The Potential of HDAC Inhibitors as Cognitive Enhancers

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

(2017) Yitshak I. Francis et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

HDAC1 Regulates Fear Extinction in Mice

(2012) S. Bahari-Javan et al.   JOURNAL OF NEUROSCIENCE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Intracellular Trafficking of Histone Deacetylase 4 Regulates Long-Term Memory Formation

(2011) Wen-Han Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML

(2011) J. M. Scandura et al.   BLOOD

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement

(2011) Jose P Lopez-Atalaya et al.   EMBO JOURNAL

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein–Taybi syndrome

(2011) J P Lopez-Atalaya et al.   JOURNAL OF MEDICAL GENETICS

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory

(2011) S. A. Maddox et al.   LEARNING & MEMORY

HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner

(2011) J. Haettig et al.   LEARNING & MEMORY

Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory

(2011) J. D. Hawk et al.   LEARNING & MEMORY

The role of histone acetylation in age-associated memory impairment and Alzheimer’s disease

(2011) Roman Manuel Stilling et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity

(2011) Stephen J. Haggarty et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Epigenetic Mechanisms in Cognition

(2011) Jeremy J. Day et al.   NEURON

Cognitive Enhancement: Promises and Perils

(2011) Steven E. Hyman   NEURON

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

Epigenetic Alterations Are Critical for Fear Memory Consolidation and Synaptic Plasticity in the Lateral Amygdala

(2011) Melissa S. Monsey et al.   PLoS One

Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus

(2011) Hiromasa Funato et al.   PLoS One

Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory

(2011) E. Lesburgueres et al.   SCIENCE

Mapping the Road Forward in Alzheimer's Disease

(2011) D. M. Holtzman et al.   Science Translational Medicine

Confirmed rare copy number variants implicate novel genes in schizophrenia

(2010) Gloria W.C. Tam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Membrane-Associated Glucocorticoid Activity Is Necessary for Modulation of Long-Term Memory via Chromatin Modification

(2010) B. Roozendaal et al.   JOURNAL OF NEUROSCIENCE

Histone Methylation Regulates Memory Formation

(2010) S. Gupta et al.   JOURNAL OF NEUROSCIENCE

The specific role of histone deacetylase 2 in adult neurogenesis

(2010) Melanie Jawerka et al.   Neuron Glia Biology

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [11C]MS-275 using Positron Emission Tomography

(2009) Jacob M. Hooker et al.   ACS Chemical Neuroscience

Epigenetic dysregulation in cognitive disorders

(2009) Johannes Gräff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Protein Phosphatase 1 Regulates the Histone Code for Long-Term Memory

(2009) K. Koshibu et al.   JOURNAL OF NEUROSCIENCE

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Histone acetylation is recruited in consolidation as a molecular feature of stronger memories

(2009) N. Federman et al.   LEARNING & MEMORY

Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

(2009) S. Jessberger et al.   LEARNING & MEMORY

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

The molecular and cellular biology of enhanced cognition

(2009) Yong-Seok Lee et al.   NATURE REVIEWS NEUROSCIENCE

A single standard for memory: the case for reconsolidation

(2009) Karim Nader et al.   NATURE REVIEWS NEUROSCIENCE

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Modulation of long-term memory for object recognition via HDAC inhibition

(2009) D. P. Stefanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction improves memory in elderly humans

(2009) A. V. Witte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic codes in cognition and behaviour

(2008) Johannes Gräff et al.   BEHAVIOURAL BRAIN RESEARCH

Catalysis and substrate selection by histone/protein lysine acetyltransferases

(2008) Christopher E Berndsen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice

(2008) Ángela Fontán-Lozano et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Poll results: look who's doping

(2008) Brendan Maher   NATURE

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

(2008) Alexi Nott et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON