Article
Anesthesiology
Yukino Oshima, Makoto Sano, Ichie Kajiwara, Yoshimi Ichimaru, Tomoaki Itaya, Tomoya Kuramochi, Emiko Hayashi, Jinsuk Kim, Osamu Kitajima, Yohei Masugi, Atsushi Masamune, Hideaki Ijichi, Yukimoto Ishii, Takahiro Suzuki
Summary: In this study, we found that midazolam can inhibit the proliferation and inflammatory response of pancreatic ductal adenocarcinoma, thereby slowing down its progression. This drug also has analgesic effects on cancer-associated pain.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Pharmacology & Pharmacy
Hongyu Zhou, Yang Zhang, Yuan Tian, Yushi Sun, Yajuan Chen, Yanli Zhang, Qin Zhu, Junfang Pan, Chen Qing
Summary: In this study, a novel prodrug NCP4 of 9-NC was designed and synthesized. The preclinical evaluation showed that NCP4 could be converted into active metabolites of 9-NC and exhibited similar anti-tumor efficacy. NCP4 induced tumor cell apoptosis by increasing the expressions of caspase-3 and Bax in tumor tissues.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Han Yu, Chao Liu, Fenghua Zhang, Jianfei Wang, Jun Han, Xin Zhou, Yueqiang Wen, Tao Shen
Summary: This study demonstrated that Zhuyu Pill (ZYP) could effectively improve biochemical parameters in a rat model of cholestasis by modulating fecal microbiota and metabolite levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Yi Zhao, Long An, Shupan Guo, Xiaoxing Huang, Huajie Tian, Li Liu, Tao Chen, Xun Sun, Qibing Mei, Rutao Wang
Summary: LMR-101 is a bisphenol derivative of propofol with potential as a treatment for epilepsy and status epilepticus. In mouse studies, LMR-101 showed strong anticonvulsant effects and minimal sedation compared to propofol, potentially binding to a novel target site on GABA(A) receptors.
Article
Psychology, Social
Emma O'Dwyer, Neus Beascoechea-Segui, Luiz Gustavo Silva Souza
Summary: The study found that identification with mutual aid groups was associated with more positive group perceptions and better self-reported psychological outcomes, while perceived group politicization showed the reverse pattern. The effect of group identification on coping self-efficacy was serially mediated by perceived support and collective efficacy.
JOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Lakeisha A. Lewter, Lalit K. Golani, James M. Cook, Jun-Xu Li
Summary: This study investigated the role of GABA(A) receptor subtypes in mediating tolerance to midazolam-induced antinociception. The results suggest that the alpha 1-subtype of GABA(A) receptors plays an essential role in the development of tolerance to midazolam's antinociceptive effects, potentially offering a way to enhance the therapeutic profiles of benzodiazepines by selectively blocking specific alpha-subtypes of GABA(A) receptors.
BEHAVIOURAL PHARMACOLOGY
(2021)
Article
Psychology, Developmental
Eugene Merzon, Iris Manor, Ann Rotem, Tzipporah Schneider, Shlomo Vinker, Avivit Golan Cohen, Ari Lauden, Abraham Weizman, Ilan Green
Summary: Untreated ADHD appears to be a risk factor for Covid-19 infection, while drug treatment can mitigate this effect.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Cell Biology
Martin Gabay, Abraham Weizman, Nidal Zeineh, Meygal Kahana, Fadi Obeid, Nahum Allon, Moshe Gavish
Summary: The main obstacle in treating brain tumors is the lack of effective therapeutic strategies capable of penetrating the blood-brain barrier.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Pavel Golubchik, Abraham Weizman
Summary: Anxiety disorders often coexist with ADHD, and treatment options include stimulants, cognitive-behavior therapy, and medication. Stimulant treatment is effective in managing ADHD with comorbid anxiety disorders, but specific treatment for anxiety is also crucial.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Developmental
Eugene Merzon, Margaret D. Weiss, Samuele Cortese, Ann Rotem, Tzipporah Schneider, Stephanie G. Craig, Shlomo Vinker, Avivit Golan Cohen, Ilan Green, Shai Ashkenazi, Abraham Weizman, Iris Manor
Summary: Age, male sex, and BMI were significant risk factors for increased COVID-19 severity, while ADHD was associated with more severe symptoms and referral to hospitalization in COVID-19 infection.
JOURNAL OF ATTENTION DISORDERS
(2022)
Review
Psychology, Clinical
Noa Vardi, Gil Zalsman, Nir Madjar, Abraham Weizman, Gal Shoval
Summary: The COVID-19 pandemic has had significant implications on the mental health of mothers and their infants, with maternal stress reactions impacting infant development. Recommendations for enhancing perinatal mental health are discussed based on current research, with suggestions for future studies.
CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Environmental Sciences
Danielle Hen-Shoval, Aron Weller, Abraham Weizman, Gal Shoval
Summary: Depression and anxiety disorders are common and growing mental health concerns in adolescents, with antidepressant medication use increasing accordingly. Cannabis use may affect the efficacy of antidepressants, particularly among adolescents, highlighting the need for further research in this area.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Michal Taler, Irit Gil-Ad, Iris Brener, Shay Henry Hornfeld, Abraham Weizman
Summary: This study compared the effects of sertraline and citalopram on breast cancer in mice and found that sertraline can inhibit cell proliferation but promotes tumor growth in vivo. Chronic mild stress does not affect tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Eugene Merzon, Margaret Weiss, Beth Krone, Shira Cohen, Gili Ilani, Shlomo Vinker, Avivit Cohen-Golan, Ilan Green, Ariel Israel, Tzipporah Schneider, Shai Ashkenazi, Abraham Weizman, Iris Manor
Summary: This study examines the factors associated with diagnosis of long COVID syndrome in children. The findings show that children with long COVID syndrome are more likely to have severe symptoms, require hospitalization, and have recurrent acute infections. They are also more likely to have ADHD, chronic urticaria, and allergic rhinitis. The study suggests that clinicians should be vigilant for the possibility of long COVID syndrome in children with pre-existing ADHD. Further research on morbidity related to long COVID syndrome in children is needed.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Microbiology
Sheelu Monga, Basem Fares, Rami Yashaev, Dov Melamed, Meygal Kahana, Fuad Fares, Abraham Weizman, Moshe Gavish
Summary: Macrophages are important immune cells responsible for creating an inflammatory immune response. This study found that a natural-based formulation (NBF) can inhibit the inflammatory response of macrophages and attenuate the release of inflammatory markers. NBF may be a potential candidate for the treatment of inflammatory diseases.
Article
Neurosciences
Yael Yuhas, Shai Ashkenazi, Eva Berent, Abraham Weizman
Summary: Schizophrenia is a chronic neurodevelopmental psychotic disorder that involves the immune system and neuroinflammation. Clozapine, an atypical antipsychotic, has been found to have immunomodulatory effects in an astroglial model of neuroinflammation. This study suggests that clozapine can inhibit the production of inflammatory mediators and increase COX2 expression, potentially benefiting patients with treatment-resistant schizophrenia and neuroinflammatory markers.
Article
Pediatrics
Gherta Brill, Iris Manor, Roberta Bril Paroz, Shai Ashkenazi, Shira Cohen, Avivit Golan-Cohen, Ilan Green, Ariel Israel, Shlomo Vinker, Abraham Weizman, Eugene Merzon
Summary: This study evaluated the association between growth hormone treatment and the risk of COVID-19 infection in children. The results show that children receiving growth hormone treatment have a lower risk of SARS-CoV-2 positivity, suggesting that growth hormone may act as a protective factor possibly due to its immunomodulatory activity.
Article
Nutrition & Dietetics
Orit Uziel, Hadar Dickstein, Einat Beery, Yael Lewis, Ron Loewenthal, Eran Uziel, Zipi Shochat, Abraham Weizman, Daniel Stein
Summary: The length of telomeres in anorexia nervosa (AN) patients is shorter and does not recover after inpatient treatment. Patients with the restricting type of AN have longer telomeres compared to those with the binge/purge type. Age is the only factor associated with telomere shortening.
Article
Nutrition & Dietetics
Eugene Merzon, Eli Magen, Shai Ashkenazi, Abraham Weizman, Iris Manor, Beth Krone, Ilan Green, Avivit Golan-Cohen, Shlomo Vinker, Stephen V. Faraone, Ariel Israel
Summary: This study found an association between G6PD deficiency and an increased risk of ADHD diagnosis. Individuals with G6PD deficiency were more likely to seek care from adult neurologists and psychiatrists. Moreover, they had a higher usage of stimulant medications.
Article
Education, Special
Hagit Nagar Shimoni, Yael Leitner, Roni Yoran-Hegesh, Ya'arit Bokek-Cohen, Shahar Gindi, Abraham Weizman
Summary: Clinical observations suggest that girls suspected to have ASD may have better performance in social and emotional tasks than boys, leading to under-diagnosis of girls with ASD. The study found that girls diagnosed with ASD performed better than boys in the Person index of the Social Attribution Task (SAT), indicating that girls with ASD may not have better social understanding than boys, except when prompted to name human traits.
INTERNATIONAL JOURNAL OF DISABILITY DEVELOPMENT AND EDUCATION
(2023)
Article
Psychiatry
Maya Schwartz-Lifshitz, David H. Ben-Dor, Yael Bustan, Gil Zalsman, Doron Gothelf, Abraham Weizman, Ran Barzilay
Summary: This retrospective study analyzed the clinical and demographic characteristics of adolescents admitted to an acute psychiatric inpatient unit. The findings showed that adolescents with deliberate self-harm (DSH) were more likely to be female, currently experiencing depressive exacerbation, have concurrent suicidal ideation, and a history of alcohol use. There were no significant clinical differences between adolescents admitted following a suicide attempt and those engaging in non-suicidal self-injury.
ARCHIVES OF SUICIDE RESEARCH
(2022)
