Article
Multidisciplinary Sciences
Armin Yazdani, Belal Howidi, Meng Zhu Shi, Nicol Tugarinov, Zehra Khoja, Pia Wintermark
Summary: The study showed that HI induced hippocampal atrophy and neuronal injury, while sildenafil treatment preserved hippocampal morphology, reduced apoptosis, promoted neuronal development, and had neuroprotective and neurorestorative effects in the neonatal hippocampus following HI.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Lei Shi, Zhu Xia, Jiamei Guo, Lixia Wang, Zhiping Peng, Dachuan Qiu, Yi Zhou, Dongdong Zhou, Li Kuang, Tian Qiu
Summary: This study investigates the effects of Maresin-1 on depression and neuroinflammation, finding that it can partially relieve depressive-like behaviors induced by lipopolysaccharide. It is also discovered that this effect is related to its anti-inflammatory action on microglia.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Ricardo Augusto Leoni De Sousa, Marco Fabricio Dias Peixoto, Hercules Ribeiro Leite, Lucas Renan Sena de Oliveira, Daniel Almeida Freitas, Fidelis Antonio da Silva-Junior, Henoque Santos Oliveira, Etel Rocha-Vieira, Ricardo Cardoso Cassilhas, Danilo Bretas de Oliveira
Summary: This study investigated the neurological consequences of exercise during prenatal Zika virus (ZIKV) exposure in mice pups. The results showed that prenatal exercise prevented brain atrophy, development of depression, anxiety, and disruption of social behavior. Prenatal exercise inhibited the overexpression of microglia and astrocytes in the hippocampus, with a reduction in BDNF levels.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Rodrigo Moraga-Amaro, Raul Diaz-Galarce, Juan P. Donoso-Ramos, Valentina Ugalde, Sergio Linsambarth, Janine Doorduin, Erik FJ. de Vries, Estibaliz Ampuero, Francisca Pena, Rodrigo Pacheco, Ursula Wyneken, Jimmy Stehberg
Summary: This study evaluated the effects of prenatal fluoxetine exposure on memory and emotional behavior of rat offspring. Results showed that male rats exposed to fluoxetine during gestation displayed memory impairments and increased anxiety- and depressive-like symptoms in adulthood.
Article
Medicine, Research & Experimental
Eunbi Cho, Se Jin Jeon, Jieun Jeon, Jee Hyun Yi, Huiyoung Kwon, Hyun-Ji Kwon, Kyoung Ja Kwon, Minho Moon, Chan Young Shin, Dong Hyun Kim
Summary: Phyllodulcin, a component of hydrangea, can inhibit the aggregation of A beta and improve memory impairments in AD mice, suggesting it may be a potential treatment for AD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Toxicology
Wei Sun, Yang Yang, Xiao Chen, Yazi Mei, Xiaoliang Li, Lei An
Summary: The study found that prenatal exposure to cyanuric acid can cause cognitive and synaptic impairments due to the disruption of hippocampal mGluR1 signaling. These findings provide the first evidence for the deteriorated effects of cyanuric acid on synaptic depression and advanced cognitive performance.
TOXICOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Zhihui Zhang, Xiao Tian, J. Yuyang Lu, Kathryn Boit, Julia Ablaeva, Frances Tolibzoda Zakusilo, Stephan Emmrich, Denis Firsanov, Elena Rydkina, Seyed Ali Biashad, Quan Lu, Alexander Tyshkovskiy, Vadim N. Gladyshev, Steve Horvath, Andrei Seluanov, Vera Gorbunova
Summary: Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and longevity in naked mole-rats. A study showed that overexpressing the naked mole-rat hyaluronic acid synthase 2 gene (nmrHas2) in mice resulted in increased hyaluronan levels, reduced incidence of cancer, extended lifespan, and improved healthspan. The beneficial effects were mediated by HMM-HA and not specific to the nmrHas2 gene, suggesting that the longevity mechanism observed in naked mole-rats can be transferred to other species.
Article
Neurosciences
Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu
Summary: The study reveals that altered levels of miR-211-5p in the hippocampal DG area have a significant impact on neurogenesis, apoptosis, and depression-like behaviors in rats. Specifically, up-regulation of miR-211-5p can alleviate depression-like behaviors, reduce neuronal apoptosis, and promote neuronal regeneration; while down-regulation of miR-211-5p can induce depression-like behaviors, increase neuronal apoptosis, and decrease neuronal regeneration.
Article
Nutrition & Dietetics
Kaylee K. Helfrich, Nipun Saini, Sze Ting Cecilia Kwan, Olivia C. Rivera, Rachel Hodges, Susan M. Smith
Summary: Prenatal alcohol exposure can cause neurodevelopmental disability and functional iron deficiency in the fetus. However, gestational administration of Fer-In-Sol, a clinically relevant iron supplement, can mitigate alcohol's adverse impacts on the fetus.
Article
Food Science & Technology
Jin Ye, Renjie Shi, Hua Fan, Danna Wang, Chunxia Xiao, Tianyingzi Yang, Peng Ye, Bing Xia, Beita Zhao, Yutang Wang, Xuebo Liu
Summary: Stevioside has a beneficial effect on postpartum cognitive and mood disorders induced by prenatal obesity. It improves behavioral performance, inhibits neuronal damage and abnormality in 5-hydroxytryptamine levels induced by a high-fat diet. Additionally, stevioside reduces oxidative stress, improves gut barrier integrity, and alleviates neuroinflammation. These outcomes are associated with the restoration of intestinal barrier integrity and reduction of lipopolysaccharide extravasation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Psychiatry
Yue Li, Yanmin Luo, Jing Tang, Xin Liang, Jin Wang, Qian Xiao, Peilin Zhu, Kai Xiao, Lin Jiang, Xiaoyun Dou, Chunxia Huang, Yuhan Xie, Yong Tang
Summary: Running exercise has been shown to alleviate depressive symptoms and protect hippocampal astrocytes in depressed rats. The positive effects of running exercise on astrocytes and the generation of new astrocytes in the hippocampus might be important structural bases for the antidepressant effects of running exercise.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Shirelle X. Liu, Tenille K. Fredrickson, Natalia Calixto Mancipe, Michael K. Georgieff, Phu V. Tran
Summary: Fetal-neonatal iron deficiency (ID) causes long-term neurocognitive and affective dysfunctions, with sex-specific effects that are poorly understood at the molecular level. In this study using a rat model, both ID and prenatal choline treatment induced sex-specific transcriptome alterations in the adult rat hippocampus. ID induced changes in gene networks related to enhanced neuroinflammation, while choline supplementation partially rescued ID-induced dysregulation and had both beneficial and adverse effects on hippocampal gene expression.
Article
Neurosciences
Pablo San Segundo, Beatrice Terni, Artur Llobet
Summary: Presynaptic terminals in the central nervous system can release neurotransmitters synchronously through either univesicular or multivesicular mechanisms, but the functional implications of one mechanism prevailing over the other remain unresolved. In this study, the liberation of glutamate and its effects on excitatory postsynaptic currents were examined using a glutamate sensor expressed in glial cells in hippocampal neuronal cultures. Optical detection revealed heterogeneous neurotransmitter release probabilities among the studied synaptic boutons, with each neuron exhibiting a predominant release mechanism. Multivesicular release was found to enhance synaptic strength and short-term synaptic depression. These findings indicate that the preference of hippocampal boutons to synchronously release one or more vesicles determines the strength and low pass filtering properties of the synapses formed.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Jehoon Lee, Vishal Naik, Marcus Orzabal, Raine Lunde-Young, Jayanth Ramadoss
Summary: Prenatal alcohol exposure can lead to increased dendritic arborization in the developing rat hippocampus, potentially playing a critical role in FASD neurobiological phenotypes.
Article
Neurosciences
Gunuputi Sushma, Bhupesh Vaidya, Shikha Sharma, Geetanjali Devabattula, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Shyam S. Sharma
Summary: This study evaluated the efficacy of probiotic supplementation using Bifidobacterium breve Bif11 in ameliorating LPS-induced depression-like behavior. The results showed that daily supplementation with B. breve Bif11 prevented the onset of depression-like behavior, reduced inflammation, and improved gut function.
Letter
Pediatrics
Christophe Milesi, Julien Baleine, Gilles Cambonie
JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Veronique Pierrat, Laetitia Marchand-Martin, Stephane Marret, Catherine Arnaud, Valerie Benhammou, Gilles Cambonie, Thierry Debillon, Marie-Noelle Dufourg, Catherine Gire, Francois Goffinet, Monique Kaminski, Alexandre Lapillonne, Andrei Scott Morgan, Jean-Christophe Roze, Sabrina Twilhaar, Marie-Aline Charles, Pierre-Wes Ancel
Summary: This study aimed to describe neurodevelopment at age 5 among children born preterm. The results showed that rates of neurodevelopment disabilities increased as gestational age decreased and were higher in families with low socioeconomic status. The findings indicate that early interventions and support are crucial for preterm children to optimize their development outcomes.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Nursing
Laurence Chandebois, Erika Nogue, Catherine Bouschbacher, Sabine Durand, Florence Masson, Renaud Mesnage, Nicolas Nagot, Gilles Cambonie
Summary: This study assessed nurses' ability to observe newborn behavior after training by NIDCAP experts. Despite some inaccuracies during care, nurses generally showed satisfactory observation skills. Disseminating observation skills among caregivers may lead to improved patient care quality and better communication among professionals.
Article
Pediatrics
Maliha Badr, Marion Goulard, Benedicte Theret, Agathe Roubertie, Stephanie Badiou, Roselyne Pifre, Virginie Bres, Gilles Cambonie
Summary: Massive intravenous lipid emulsion (ILE) overdose in neonates, although rare, can lead to severe complications and even death. Vigilance is crucial when administering ILE separately from other parenteral intakes to prevent such life-threatening adverse events. Early recognition and prompt management, such as exchange transfusion, are essential for improving outcomes in these cases.
Article
Pharmacology & Pharmacy
Fatiha Sebih, Nawfel Mokrane, Pierre Fontanel, Mete Kayatekin, Mahira Kaabeche, Janique Guiramand, Catherine Cohen-Solal, Thierry Cens, Matthieu Rousset, Pierre Charnet, Marie-Celeste De Jesus Ferreira, Jean-Baptiste Thibaud, Claudine Menard, Sonia Cantel, Valerie Rolland, Michel Vignes, Julien Roussel
Summary: The study found that gamma-Glu-Glu can exert excitatory effects by activating neuronal NMDA receptors when GSH production is enhanced. Additionally, gamma-Glu-Glu partially activates NMDA receptors and exhibits better efficacy for NMDA receptors containing the GluN2B subunit.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pediatrics
Barthelemy Tosello, Sahra Meziane, Noemie Resseguier, Stephane Marret, Gilles Cambonie, Meriem Zahed, Veronique Brevaut-Malaty, Any Beltran Anzola, Catherine Gire
Summary: In a study of 231 school-aged extremely preterm children without major disabilities, three neurobehavioral phenotypes were defined according to severity: moderate, minor, and unimpaired. All profiles showed working memory, perceptual reasoning, and mental flexibility closer to or below average, with emotional behavior consistently troubled. Self-esteem and school-work were the most impacted areas of quality of life. The deterioration of quality of life was associated with the severity of neurobehavioral phenotypes, as well as with dysexecutive and/or behavioral disorders.
Review
Chemistry, Organic
Thierry Cens, Alain Chavanieu, Anais Bertaud, Nawfel Mokrane, Sebastien Estaran, Julien Roussel, Claudine Menard, Marie-Celeste De Jesus Ferreira, Janique Guiramand, Jean-Baptiste Thibaud, Catherine Cohen-Solal, Matthieu Rousset, Valerie Rolland, Michel Vignes, Pierre Charnet
Summary: The worldwide decrease in insect populations over the past twenty years may be attributed to the intensive use of insecticides and habitat loss, among other factors. However, due to the role of pest species in crop destruction and vector-borne diseases, insecticides will likely remain necessary for decades to come. This article provides an overview of insecticides that act on specific ion channels in the central nervous system of insects. The knowledge on these ion channels in honeybees is summarized, and the potential mode of action of neurotoxic insecticides is discussed.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lorene Brunello, Claudine Menard, Matthieu Rousset, Michel Vignes, Pierre Charnet, Thierry Cens
Summary: Heterologous expression systems are important for studying ionotropic receptors, but insect receptors require co-expression of chaperone proteins. This study compared different protein combinations and found that only a few combinations were able to successfully express functional receptors in Xenopus oocytes.
INSECT MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matthieu Rousset, Sandrine Humez, Cyril Laurent, Luc Buee, David Blum, Thierry Cens, Michel Vignes, Pierre Charnet
Summary: Mutations on voltage-gated calcium channels can cause neurological disorders and contribute to various conditions. By transplanting membrane preparations of these channels into Xenopus oocytes, their activity can be conserved, allowing for the study of calcium signaling.
Article
Biochemistry & Molecular Biology
Anais Bertaud, Thierry Cens, Rosanna Mary, Matthieu Rousset, Elodie Arel, Jean-Baptiste Thibaud, Michel Vignes, Claudine Menard, Sebastien Dutertre, Claude Collet, Pierre Charnet
Summary: By comparing the pharmacological sensitivity of GABA receptors from pea aphids, honeybees, and Varroa mites, we found a global conservation of their pharmacological profiles with some species-specific differences. This approach can be useful for the early identification of poorly specific molecules.
Article
Pharmacology & Pharmacy
Allison Carles, Audrey Schlernitzauer, Michel Vignes, Gerard Cros, Richard Magous, Tangui Maurice, Catherine Oiry
Summary: This study aims to analyze the consequences of mice's exposure to different concentrations of C4F7N gas at different time points. The results show that exposure to C4F7N gas can lead to memory impairments and brain toxicity, particularly in female mice.
Article
Biochemistry & Molecular Biology
Mathilde Folacci, Sebastien Estaran, Claudine Menard, Anais Bertaud, Matthieu Rousset, Julien Roussel, Jean-Baptiste Thibaud, Michel Vignes, Alain Chavanieu, Pierre Charnet, Thierry Cens
Summary: Cav2.1 channels are important for the regular pacemaking activity of Purkinje cells, and variations in these channels can lead to ataxia symptoms. Functional analysis revealed different effects of the four identified variations, with some causing loss-of-function and others causing channel gain-of-function. Structural analysis showed specific changes in interactions with certain helices, potentially affecting the action potential frequency in Purkinje cells.
Article
Pediatrics
Ludovic Treluyer, Alexandra Nuytten, Isabelle Guellec, Pierre-Henri Jarreau, Valerie Benhammou, Gilles Cambonie, Patrick Truffert, Laetitia Marchand-Martin, Pierre Yves Ancel, Heloise Torchin
Summary: This study aimed to investigate the neurodevelopmental outcomes and healthcare utilization of very preterm children with bronchopulmonary dysplasia (BPD) at age 5-6 years. The results showed that BPD was strongly associated with various neurodevelopmental disabilities, including behavioral difficulties, developmental coordination disorders, and lower IQ scores.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Biochemical Research Methods
Pauline Duc, Michel Vignes, Gerald Hugon, Audrey Sebban, Gilles Carnac, Eugene Malyshev, Benoit Charlot, Florence Rage
Summary: The study combines microfluidics, soft lithography, and custom microelectrodes array technology to create hNMJs on specific pattern of electrodes, stimulating pre-synaptic axons and recording post-synaptic muscle activity. This platform allows for mature and functional in vitro modeling of hNMJs, demonstrating that electrical activation of MNs can trigger recordable extracellular muscle action potentials.
Meeting Abstract
Neurosciences
N. Mokrane, T. Cens, P. Charnet, C. Menard, J. Guiramand, M. Rousset, C. Cohen-Solal, J. Roussel, M. Vignes