Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats

Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation

(2011) Alkomiet Hasan et al.   BEHAVIOURAL BRAIN RESEARCH

GABAA Receptor Subtype-Selective Modulators. II. α5-Selective Inverse Agonists for Cognition Enhancement

(2011) John R. Atack   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Novel α5GABAAR-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia

(2011) Kathryn M Gill et al.   NEUROPSYCHOPHARMACOLOGY

Tryptophan depletion impairs object-recognition memory in the rat: Reversal by risperidone

(2010) Trisha A. Jenkins et al.   BEHAVIOURAL BRAIN RESEARCH

A Randomized Clinical Trial of MK-0777 for the Treatment of Cognitive Impairments in People with Schizophrenia

(2010) Robert W. Buchanan et al.   BIOLOGICAL PSYCHIATRY

Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia

(2010) Samantha L. McLean et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Recognition memory: Material, processes, and substrates

(2010) Malcolm W. Brown et al.   HIPPOCAMPUS

The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: A meta-analysis

(2010) Anne-Kathrin J. Fett et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

(2010) Joanna C. Neill et al.   PHARMACOLOGY & THERAPEUTICS

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

(2010) Xiao-Jing Wang   PHYSIOLOGICAL REVIEWS

Erythropoietin reverses the attentional set-shifting impairment in a rodent schizophrenia disease-like model

(2010) Pascal Jean Denis Goetghebeur et al.   PSYCHOPHARMACOLOGY

Mutant Mouse Models: Phenotypic Relationships to Domains of Psychopathology and Pathobiology in Schizophrenia

(2010) C. M. P. O'Tuathaigh et al.   SCHIZOPHRENIA BULLETIN

Etomidate Targets α5 γ-Aminobutyric Acid Subtype A Receptors to Regulate Synaptic Plasticity and Memory Blockade

(2009) Loren J. Martin et al.   ANESTHESIOLOGY

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats

(2009) Trine Damgaard et al.   BEHAVIOURAL BRAIN RESEARCH

Role of GABAAreceptors in cognition: Table 1

(2009) Hanns Möhler   BIOCHEMICAL SOCIETY TRANSACTIONS

Discrimination Learning, Reversal, and Set-Shifting in First-Episode Schizophrenia: Stability Over Six Years and Specific Associations with Medication Type and Disorganization Syndrome

(2009) Verity C. Leeson et al.   BIOLOGICAL PSYCHIATRY

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

(2009) Henner Knust et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphodiesterase 10A inhibition modulates the sensitivity of the mesolimbic dopaminergic system to d-amphetamine: involvement of the D1-regulated feedback control of midbrain dopamine neurons

(2009) Florence Sotty et al.   JOURNAL OF NEUROCHEMISTRY

Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

(2009) D. Belelli et al.   JOURNAL OF NEUROSCIENCE

Chronic infusion of PCP via osmotic mini-pumps: A new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance

(2009) Christian Spang Pedersen et al.   JOURNAL OF NEUROSCIENCE METHODS

Attenuation of Phencyclidine-Induced Object Recognition Deficits by the Combination of Atypical Antipsychotic Drugs and Pimavanserin (ACP 103), a 5-Hydroxytryptamine2A Receptor Inverse Agonist

(2009) S. Snigdha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

(2009) Jared W. Young et al.   PHARMACOLOGY & THERAPEUTICS

Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

(2009) John R. Atack   PHARMACOLOGY & THERAPEUTICS

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia—sub-chronic and early postnatal PCP treatment in attentional set-shifting

(2009) Brian Villumsen Broberg et al.   PSYCHOPHARMACOLOGY

Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT6 and 5-HT2A receptor mechanisms

(2009) Nagi Idris et al.   PSYCHOPHARMACOLOGY

Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia

(2008) David A. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

Reduced Evoked Gamma Oscillations in the Frontal Cortex in Schizophrenia Patients: A TMS/EEG Study

(2008) Fabio Ferrarelli et al.   AMERICAN JOURNAL OF PSYCHIATRY

Evaluation of a neurodevelopmental model of schizophrenia—Early postnatal PCP treatment in attentional set-shifting

(2008) Brian Villumsen Broberg et al.   BEHAVIOURAL BRAIN RESEARCH

Which GABAA Receptor Subunits Are Necessary for Tonic Inhibition in the Hippocampus?

(2008) J. Glykys et al.   JOURNAL OF NEUROSCIENCE

Antipsychotic-Like Effect of Retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic Acid Ester], a KCNQ Potassium Channel Opener, via Modulation of Mesolimbic Dopaminergic Neurotransmission

(2008) F. Sotty et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval

(2008) Boyer D. Winters et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

(2008) Theresa M. Ballard et al.   PSYCHOPHARMACOLOGY

Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study

(2008) Pascal Goetghebeur et al.   PSYCHOPHARMACOLOGY

The Role of Oscillations and Synchrony in Cortical Networks and Their Putative Relevance for the Pathophysiology of Schizophrenia

(2008) P. J. Uhlhaas et al.   SCHIZOPHRENIA BULLETIN

Reinforcement and Reversal Learning in First-Episode Psychosis

(2008) G. K. Murray et al.   SCHIZOPHRENIA BULLETIN

CNTRICS Final Task Selection: Executive Control

(2008) D. M. Barch et al.   SCHIZOPHRENIA BULLETIN

Hippocampal α5 subunit-containing GABAA receptors are involved in the development of the latent inhibition effect

(2007) T.V. Gerdjikov et al.   NEUROBIOLOGY OF LEARNING AND MEMORY