The inhibitory GABA system as a therapeutic target for cognitive symptoms in schizophrenia: investigational agents in the pipeline

Reversal of Ketamine-Induced Working Memory Impairments by the GABAAα2/3 Agonist TPA023

(2010) Stacy A. Castner et al.   BIOLOGICAL PSYCHIATRY

GABA Concentration Is Reduced in Visual Cortex in Schizophrenia and Correlates with Orientation-Specific Surround Suppression

(2010) J. H. Yoon et al.   JOURNAL OF NEUROSCIENCE

Abnormal neural oscillations and synchrony in schizophrenia

(2010) Peter J. Uhlhaas et al.   NATURE REVIEWS NEUROSCIENCE

Assessing cognitive function in clinical trials of schizophrenia

(2010) Jennifer H. Barnett et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Atypical behavioural effects of lorazepam: Clues to the design of novel therapies?

(2010) Anne Giersch et al.   PHARMACOLOGY & THERAPEUTICS

A Recombination Hotspot in a Schizophrenia-Associated Region of GABRB2

(2010) Siu-Kin Ng et al.   PLoS One

Cognitive Effects of Antipsychotic Drugs in First-Episode Schizophrenia and Schizophreniform Disorder: A Randomized, Open-Label Clinical Trial (EUFEST)

(2009) Michael Davidson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Altered Markers of Tonic Inhibition in the Dorsolateral Prefrontal Cortex of Subjects With Schizophrenia

(2009) Jaime G. Maldonado-Avilés et al.   AMERICAN JOURNAL OF PSYCHIATRY

Protracted Developmental Trajectories of GABAA Receptor α1 and α2 Subunit Expression in Primate Prefrontal Cortex

(2009) Takanori Hashimoto et al.   BIOLOGICAL PSYCHIATRY

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

(2009) Henner Knust et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

(2009) D. Belelli et al.   JOURNAL OF NEUROSCIENCE

Cortical Oscillatory Activity Is Critical for Working Memory as Revealed by Deficits in Early-Onset Schizophrenia

(2009) C. Haenschel et al.   JOURNAL OF NEUROSCIENCE

In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor  5 Subtype-Selective Inverse Agonist

(2009) J. R. Atack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Reducing Abuse Liability of GABAA/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at  1 and  2/3 Subtypes

(2009) N. A. Ator et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine

(2009) W. Michael Bullock et al.   NEUROCHEMISTRY INTERNATIONAL

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

(2009) Jared W. Young et al.   PHARMACOLOGY & THERAPEUTICS

Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

(2009) John R. Atack   PHARMACOLOGY & THERAPEUTICS

Mechanism for top-down control of working memory capacity

(2009) F. Edin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

(2009) O. D. Howes et al.   SCHIZOPHRENIA BULLETIN

Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia

(2009) Clement C. Zai et al.   SCHIZOPHRENIA RESEARCH

GABA concentration in schizophrenia patients and the effects of antipsychotic medication: A proton magnetic resonance spectroscopy study

(2009) Shin'Ya Tayoshi et al.   SCHIZOPHRENIA RESEARCH

Modeling cognitive endophenotypes of schizophrenia in mice

(2009) Christoph Kellendonk et al.   TRENDS IN NEUROSCIENCES

Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia

(2008) David A. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

The MATRICS Consensus Cognitive Battery, Part 1: Test Selection, Reliability, and Validity

(2008) Keith H. Nuechterlein et al.   AMERICAN JOURNAL OF PSYCHIATRY

General and Specific Cognitive Deficits in Schizophrenia: Goliath Defeats David?

(2008) Dwight Dickinson et al.   BIOLOGICAL PSYCHIATRY

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning in rats

(2008) Miroslav M. Savić et al.   BRAIN RESEARCH

GABAAReceptor Subtype-Selective Efficacy: TPA023, an α2/α3 Selective Non-sedating Anxiolytic and α5IA, an α5 Selective Cognition Enhancer

(2008) John R. Atack   CNS Neuroscience & Therapeutics

NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic Properties and in Vivo Anxiolytic Efficacy

(2008) N. R. Mirza et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

(2008) Nicole C Allen et al.   NATURE GENETICS

Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus

(2008) K.A. Wafford et al.   NEUROPHARMACOLOGY

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

(2008) Theresa M. Ballard et al.   PSYCHOPHARMACOLOGY

GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia

(2008) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE

GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for α5 subunit

(2007) Yoshiyuki Asai et al.   SCHIZOPHRENIA RESEARCH

General and social cognition in first episode schizophrenia: Identification of separable factors and prediction of functional outcome using the IntegNeuro test battery

(2007) Leanne M. Williams et al.   SCHIZOPHRENIA RESEARCH