The complexity of integrins in cancer and new scopes for therapeutic targeting

Elucidation of the Roles of Tumor Integrin  1 in the Extravasation Stage of the Metastasis Cascade

(2016) M. B. Chen et al.   CANCER RESEARCH

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

(2016) Adam Byron et al.   CURRENT OPINION IN CELL BIOLOGY

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

(2016) Noel P. Fusté et al.   Nature Communications

Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes

(2016) Rachel Barrow-McGee et al.   Nature Communications

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

(2016) Riina Kaukonen et al.   Nature Communications

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

(2016) M. J. Oudin et al.   Cancer Discovery

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

(2015) Alan Serrels et al.   CELL

Filopodia in cell adhesion, 3D migration and cancer cell invasion

(2015) Guillaume Jacquemet et al.   CURRENT OPINION IN CELL BIOLOGY

The αvβ6Integrin Is Transferred Intercellularly via Exosomes

(2015) Carmine Fedele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer

(2015) R Navab et al.   ONCOGENE

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

(2015) Laetitia Seguin et al.   TRENDS IN CELL BIOLOGY

The ZNF304-integrin axis protects against anoikis in cancer

(2015) Burcu Aslan et al.   Nature Communications

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

(2015) Ridwana Chowdhury et al.   Oncotarget

Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients withKRASwild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial

(2014) E. Élez et al.   ANNALS OF ONCOLOGY

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells

(2014) Ghaffar Muharram et al.   DEVELOPMENTAL CELL

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Therapeutic Targeting of Integrin αvβ6 in Breast Cancer

(2014) Kate M. Moore et al.   JNCI-Journal of the National Cancer Institute

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

Nuclear FAK: a new mode of gene regulation from cellular adhesions

(2013) Ssang-Taek Steve Lim   MOLECULES AND CELLS

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Integrin α3β1–CD151 complex regulates dimerization of ErbB2 via RhoA

(2013) V Novitskaya et al.   ONCOGENE

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

(2012) Tsukasa Shibue et al.   Cancer Discovery

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

 1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer

(2009) D. Lesniak et al.   CANCER RESEARCH

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT