Article
Biochemistry & Molecular Biology
Bar Levi, Shiri Yacobovich, Michael Kirby, Maria Becker, Oryan Agranyoni, Boris Redko, Gary Gellerman, Albert Pinhasov, Igor Koman, Elimelech Nesher
Summary: ALOS4 demonstrates anti-cancer effects in a human melanoma xenograft model, potentially acting through an integrin-mediated pathway despite no significant observed impact on tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Ziyuan Zhang, Juan Liu, Min Xiao, Quanfeng Zhang, Zhonghua Liu, Meiyan Liu, Peng Zhang, Youlin Zeng
Summary: By using KL-7 peptide nanotubes to load and deliver c-di-GMP, the study demonstrated enhanced effectiveness of c-di-GMP and its robust in situ immunity against melanoma cells. The c-di-GMP-PNT nanocomposite activated the STING pathway and promoted immune response, resulting in significant inhibition of tumor growth without obvious toxicity.
Article
Plant Sciences
Xiaoya Xu, Nan Jiang, Shangming Liu, Yang Jin, Yuhan Cheng, Tong Xu, Xin Wang, Yuanhua Liu, Mingwan Zhang, Shuhu Du, Junting Fan, Aixia Zhang
Summary: This study demonstrated that the cyclopeptide moroidin can inhibit microtubule polymerization and decrease levels of beta-tubulin protein, leading to cytotoxic effects on various cancer cells, particularly A549 lung cancer cells. Furthermore, moroidin can arrest A549 cells in the G2/M phase and induce cell apoptosis. It also has the ability to inhibit migration and invasion of A549 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Si-Yen Liu, Sheng-Nan Lo, Wan-Chi Lee, Wei-Chuan Hsu, Te-Wei Lee, Chih-Hsien Chang
Summary: Nanotargeted liposomes modified with targeting peptides show increased specificity and efficiency in tumor targeting. The development of In-111-cyclic RGDfK-liposome demonstrated the ability to recognize alpha(V)beta 3 integrin and has potential for tumor imaging applications. Additionally, it showed no significant negative effects on phagocyte function, making it a promising agent for tumor imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Qi-Ting Zhang, Ze-Dong Liu, Ze Wang, Tao Wang, Nan Wang, Ning Wang, Bin Zhang, Yu-Fen Zhao
Summary: Small peptides derived from marine organisms show promise in anticancer research due to their fast absorption and low gastrointestinal burden, offering potential advantages over traditional therapies. Further research is needed to fully understand their mechanisms and potential clinical applications.
Review
Chemistry, Multidisciplinary
Afsana Sheikh, Shadab Md, Prashant Kesharwani
Summary: A bird's eye view is needed in cancer research to address the shortcomings of chemotherapy, with targeted therapy showing promise in providing more efficient treatment for tumor cells.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Afsana Sheikh, Nabil A. Alhakamy, Shadab Md, Prashant Kesharwani
Summary: This article introduces the research progress of liposomes as drug delivery systems for cancer treatment, focusing on the modification of liposome surface to be recognized and uptaken by cancer cells, and the mechanism of targeting, accumulation, and drug release at specific sites mediated by integrin recognition.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Xinjian Ji, Alexander L. Nielsen, Christian Heinis
Summary: Cyclic peptides are a class of molecules widely found in nature and used in drug development. Advances in synthesis and drug development have led to the creation of many cyclic peptide drugs. Cyclic peptides possess favorable properties that make them attractive for drug development. Currently, there are over 40 cyclic peptide drugs in use, and new technological advances suggest that this number could rapidly increase.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yunyun Wu, Xiaoqing Han, Runxiao Zheng, Hongda Cheng, Jiao Yan, Xiaqing Wu, Yaqing Hu, Bing Li, Zhenxin Wang, Xi Li, Haiyuan Zhang
Summary: In this study, (T)LipIT/NEs were used as a drug delivery system to inhibit postoperative melanoma recurrence through neutrophil-mediated photothermal and photodynamic effects. This approach induces immunogenic cell death and activates T cells, playing an important role in enhancing immune responses.
Article
Dermatology
Breanna A. Nguyen, Jonhan Ho, Jacinto S. De La Cruz Diaz, Stephen Nishimura, Daniel H. Kaplan
Summary: This study examined the expression of integrins beta 6 and beta 8 in human skin, inflammatory skin diseases, benign nevi, and melanoma. The findings suggest that abnormal integrin expression may be involved in the development and maintenance of cutaneous inflammation as well as tumor immune evasion. High expression of integrin beta 8 is associated with deeper Breslow depth and worse prognostic staging in melanoma.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yiyuan Yang, Hui Mao, Linxi Chen, Lanfang Li
Summary: Cancer is a global health issue, with cyclic peptides playing a significant role in the occurrence and development of various types of cancer. While some cyclic peptides can prevent cancer progression, others may worsen the pathogenesis of cancer. Therefore, the identification and development of cyclic peptides and their derivatives as drugs could be an effective therapeutic strategy for cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Tatiane Senna Bialves, Claudio L. Q. Bastos, Marcos Freitas Cordeiro, Robert Tew Boyle
Summary: Despite advances in melanoma treatment, there are still challenges. Snake venom proteins/peptides show potential for binding and inhibiting melanoma cell proliferation. Combining these compounds with current therapies could lead to more effective treatments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Yang Yang, Quanfeng Zhao, Zhe Peng, Yunjiang Zhou, Miao-Miao Niu, Lin Chen
Summary: This study introduces a GSH/CB dual-controlled nanomedicine that efficiently inhibits DOX-resistant breast cancer cells, providing a new approach for breast cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiang Wu, Jihong Tian, Yiyan Zhang, Hengshan Ji, Jingjing Sun, Xingang Wang, Chuanjin Sun, Li Wang, Zhaogang Teng, Guangming Lu, Hong Zhu, Xiaoyuan Chen
Summary: This study investigated the use of F-18-Alfatide II for evaluating axillary lymph nodes (ALN) in breast cancer patients and compared its performance with F-18-FDG. The results showed that both F-18-Alfatide II and F-18-FDG can improve the diagnostic sensitivity and negative predictive value of ALN, and the T/NT parameter of F-18-Alfatide II may be the most important for evaluating ALN.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Plant Sciences
Xingxing Wei, Tsz Ki Chan, Che Tung Derek Kong, Yudai Matsuda
Summary: The biosynthetic gene cluster for the cyclic heptapeptides unguisins A and B, which contain the neurotransmitter gamma-aminobutyric acid (GABA), was discovered in the fungus Aspergillus violaceofuscus CBS 115571. Enzymatic reactions and gene deletion experiments showed that the unguisin pathway involves the alanine racemase UngC to produce D-alanine, which is then utilized by the first adenylation domain of the nonribosomal peptide synthetase UngA. Surprisingly, the hydrolase UngD was found to convert unguisins into previously unknown linear peptides. Heterologous production of these peptides was achieved in Aspergillus oryzae, and genome mining revealed new unguisin variants, each containing a (2R,3R)-beta-methylphenylalanine residue.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Avraham Dayan, Adva Yeheskel, Raphael Lamed, Gideon Fleminger, Osnat Ashur-Fabian
Summary: DLDH, a mitochondrial enzyme, exhibits moonlighting activities such as binding to TiO2 to produce ROS. It has also been shown to bind DNA, which may have implications for cancer treatment.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2021)
Article
Oncology
Dotan Moskovich, Adi Alfandari, Yael Finkelshtein, Avivit Weisz, Aviva Katzav, Debora Kidron, Evgeny Edelstein, Daniel Veroslavski, Ruth Perets, Nissim Arbib, Yfat Kadan, Ami Fishman, Bernard Lerer, Martin Ellis, Osnat Ashur-Fabian
Summary: The active thyroid hormone T3 acts as a tumor suppressor in HGSOC by promoting cell differentiation and mitochondrial respiration, but tumors evolve a strategy to avoid these effects by expressing the T3 catabolizing enzyme DIO3. Knocking down DIO3 in HGSOC cells increases T3 availability, inducing apoptosis and inhibiting tumor proliferation and growth. This study suggests DIO3 as a promising target for inhibition in HGSOC by regulating tumorigenesis and metabolic reprogramming.
Article
Clinical Neurology
Kateryna Murlanova, Izhak Michaelevski, Anatoly Kreinin, Chantelle Terrillion, Mikhail Pletnikov, Albert Pinhasov
Summary: The study found that dominant and submissive mice had different neurochemical responses and behavioral profiles to paroxetine treatment. Submissive mice showed distinct differences in brain monoamine content, and paroxetine had differential effects on the behavior of dominant and submissive mice. These results suggest neurochemical mechanisms underlying temperament-dependent responses to antidepressant treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Oncology
Avivit Weisz, Uri Abadi, Lisa Mausbach, David Gurwitz, Martin Ellis, Osnat Ashur-Fabian
Summary: This study identified the presence of nuclear alpha v beta 3 integrin in cancer cells and hematological malignancies. The research explored the role of this integrin in the nucleus, its post-translational modifications, and interactions with MAPK and PI3K signaling pathways.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bar Levi, Shiri Yacobovich, Michael Kirby, Maria Becker, Oryan Agranyoni, Boris Redko, Gary Gellerman, Albert Pinhasov, Igor Koman, Elimelech Nesher
Summary: ALOS4 demonstrates anti-cancer effects in a human melanoma xenograft model, potentially acting through an integrin-mediated pathway despite no significant observed impact on tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nomi Pernicone, Maria Elias, Itay Onn, Dror Tobi, Tamar Listovsky
Summary: Chemotherapy is a common treatment for cancer, but drug resistance limits its effectiveness. This study focuses on targeting the TLS pathway to improve chemotherapy and identifies two potential TLS inhibitors that sensitize cancer cells to chemotherapy drugs.
Review
Behavioral Sciences
Kateryna Murlanova, Michael Kirby, Lev Libergod, Mikhail Pletnikov, Albert Pinhasov
Summary: Social interactions are crucial for many species, and understanding the neural mechanisms underlying social rank behavior is important. This review discusses the use of rodent models to study social hierarchies and the development of reliable behavioral tests.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
David Bern, Dror Tobi
Summary: The Kaposi’s sarcoma-associated herpesvirus protease plays a crucial role in virus maturation. It exists in an inactive monomeric state and an active, weakly associating dimeric state that is stabilized upon ligand binding. This study demonstrates the role of the protease in mediating allosteric regulation and provides insights into its dynamics and function.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Editorial Material
Immunology
Albert Pinhasov, Michael Kirby
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Debpali Sur, Katerina Leonova, Bar Levi, Shany Ivon Markowitz, Raichel Cohen-Harazi, Ilya Gitlin, Katerina Gurova, Andrei Gudkov, Albert Pinhasov, Igor Koman, Elimelech Nesher
Summary: Interferon signaling in inflammation releases cytokines and chemokines to combat viral, bacterial, and cancerous invasions. However, prolonged exposure to interferons leads to immune exhaustion, enhancing inflammation and disease promotion. A peptide called ALOS4 has shown anti-inflammatory properties by upregulating interferon-response genes, supporting antiviral response without inhibiting interferon signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Olga Furman, Alisa Zaporozhets, Dror Tobi, Andrii Bazylevich, Michael A. Firer, Leonid Patsenker, Gary Gellerman, Bat Chen R. Lubin
Summary: In this study, a new EGFR-specific cyclic peptide was discovered using phage display peptide technology and biopanning. The peptide showed specific and selective binding and internalization into EGFR-positive cells, and demonstrated high specificity for non-small cell lung cancer and glioblastoma cells. When conjugated to camptothecin, the peptide showed increased cytotoxicity to EGFR-positive cells.
Article
Multidisciplinary Sciences
Dmitry Rodin, Yair Shapiro, Albert Pinhasov, Anatoly Kreinin, Michael Kirby
Summary: The field evaluation of a wearable body hydration sensor suggests that it can be a reliable tool for monitoring hydration and physical training in geriatric scenarios.