ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

NF-κB activation impairs somatic cell reprogramming in ageing

(2015) Clara Soria-Valles et al.   NATURE CELL BIOLOGY

Cancer cell migration in 3D tissue: Negotiating space by proteolysis and nuclear deformability

(2015) Marina Krause et al.   Cell Adhesion & Migration

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication

(2014) D. Gritenaite et al.   GENES & DEVELOPMENT

Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe

(2014) S. Sarbajna et al.   GENES & DEVELOPMENT

Breaching the nuclear envelope in development and disease

(2014) Emily Hatch et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Spatial control of the GEN1 Holliday junction resolvase ensures genome stability

(2014) Ying Wai Chan et al.   Nature Communications

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes

(2012) Maël Le Berre et al.   Integrative Biology

The ESCRT Machinery Is Recruited by the Viral BFRF1 Protein to the Nucleus-Associated Membrane for the Maturation of Epstein-Barr Virus

(2012) Chung-Pei Lee et al.   PLoS Pathogens

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Interstitial locomotion of leukocytes

(2011) Michael Sixt   IMMUNOLOGY LETTERS

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

Lifeact mice for studying F-actin dynamics

(2010) Julia Riedl et al.   NATURE METHODS

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

(2009) Holger Pflicke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Obliteration of cardiomyocyte nuclear architecture in a patient with LMNA gene mutation

(2008) Anna Fidziańska et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS

Regulation of Dendritic Cell Migration by CD74, the MHC Class II-Associated Invariant Chain

(2008) G. Faure-Andre et al.   SCIENCE