Article
Biotechnology & Applied Microbiology
Jialiang Guo, Xiaojun Chen, Zhe Lin, Lin Jin, Zhiyong Hou, Weichong Dong, Yingze Zhang
Summary: Acute compartment syndrome is an orthopedic emergency that often occurs after severe tibial plateau fracture. In this study, changes in tight junction expression in the skin after blister formation were observed. It was found that blistered skin is thinner and has significantly decreased levels of tight junction expression. This study suggests that changes in tight junction expression may contribute to blister fluid formation and the decrease in compartment pressure.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaopei Hao, Yao Zhang, Yiwei Lu, Guoyong Han, Dawei Rong, Guoqiang Sun, Guangshun Sun, Weiwei Tang, Jindao Wu, Xuehao Wang
Summary: STK39 is overexpressed in cholangiocarcinoma (CCA) and negatively associated with patient prognosis. Knockdown of STK39 suppresses cell proliferation, migration, and invasion, while overexpression promotes tumor aggressiveness. Mechanistically, STK39 enhances CCA progression through activating the PI3K/AKT signaling pathway and inducing gemcitabine resistance. Additionally, the dysregulation of miR-26a-5p may mediate the increased expression of STK39.
Article
Cell Biology
Pengling Wang, Ting Liu, Zhendan Zhao, Zhiling Wang, Shujie Liu, Xingsheng Yang
Summary: The study demonstrated that SPTBN2 is overexpressed in EEC and associated with poor prognosis, with its knockdown inhibiting cell proliferation, migration, and invasion. SPTBN2 interacts with CLDN4 to promote endometrial cancer metastasis via the PI3K/AKT pathway.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Piya Prajumwongs, Ratthaphong Phumphu, Orawan Waenphimai, Worachart Lert-itthiporn, Kulthida Vaeteewoottacharn, Sopit Wongkham, Yaovalux Chamgramol, Chawalit Pairojkul, Kanlayanee Sawanyawisuth
Summary: The study found that MPS1 plays a crucial role in the progression of CCA by promoting it through the AKT and STAT3 signaling pathways, making it a potentially attractive target for metastatic CCA treatment.
Article
Biochemistry & Molecular Biology
Anamika Sharma, Narendra Vijay Tirpude, Monika Kumari, Yogendra Padwad
Summary: The study shows the potential of rutin in treating chronic colitis by modulating multiple signaling pathways to improve disease symptoms and maintain intestinal health. Rutin not only alleviates tissue damage caused by colitis, but also regulates the expression of inflammatory proteins and controls immune responses.
Article
Oncology
Beiquan Hu, Chao Qin, Li Li, Lei Wei, Xianlun Mo, Huasheng Fan, Yuanhua Lei, Feng Wei, Donghua Zou
Summary: Our study suggests that MDK promotes GBM by activating the PI3K-Akt signaling pathway, and it describes a potential regulatory network involved. MDK is highly expressed in GBM and is associated with poor prognosis, potentially serving as a promising diagnostic and prognostic biomarker for GBM. Overexpression of MDK enhances proliferation, migration, and invasion of GBM cell lines, while suppression of MDK exerts opposite effects. The study also highlights the involvement of MDK in various cancer-related pathways, such as PI3K-Akt signaling, the cell cycle, and VEGF signaling.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Ningjing Lei, Yanru Cheng, Jiajia Wan, Rosel Blasig, Anqi Li, Yueyue Bai, Reiner F. Haseloff, Ingolf E. Blasig, Linyu Zhu, Zhihai Qin
Summary: The role of claudin-3 in tumor-induced lymphangiogenesis was investigated. It was found that overexpression of claudin-3 inhibits lymphatic endothelial cell migration, leading to restricted lymphangiogenesis.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Rui Zhao, Yuzhen Ge, Yongjun Gong, Bo Li, Benli Xiao, Shi Zuo
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. This study found that low expression of NAP1L5 in HCC was associated with shorter survival and disease-free survival. NAP1L5 inhibited the proliferation, migration, and invasion of hepatoma cells, and induced apoptosis. It also inhibited the growth and metastasis of HCC cells in vivo. Mechanistically, NAP1L5 regulated the PI3K/AKT/mTOR signaling pathway by controlling MYH9 to affect the occurrence and development of HCC. NAP1L5 may be a potential target for liver cancer treatment.
Article
Plant Sciences
Tao Wang, Zhiyuan Chen, Hui Chen, Xi Yu, Lei Wang, Xiuheng Liu
Summary: The study aimed to investigate the mechanism by which brusatol regulates the growth of renal cancer cells through the PTEN/PI3K/AKT signaling pathway. The results showed that brusatol significantly inhibited the proliferation, migration, and invasion of A498, ACHN, and OSRC-2 renal cancer cell lines, and increased apoptosis rates.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qinggang Li, Xiaonan Liu, Jian Mao, Shimin Liu, Baosen Hou, Kaiyan Li, Dandong Fang
Summary: This study reveals that the decreased expression of RRAGB in GBM is associated with poor prognosis and tumor characteristics. RRAGB up-regulation suppresses the proliferation, migration, and invasion of GBM cells through the PI3K/AKT pathway. Animal experiments demonstrate that RRAGB over-expression inhibits tumor growth and improves overall survival rates.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Weiwei Xie, Jun Yu, Yujia Yin, Xiaoqian Zhang, Xiaocui Zheng, Xipeng Wang
Summary: This study reveals the important role of OCT4 in the progression of ovarian cancer. OCT4 promotes the proliferation, migration, and invasion of cancer cells by influencing the PI3K/AKT/mTOR signaling axis and epithelial-mesenchymal transition (EMT) related proteins. Therefore, OCT4 could serve as a potential therapeutic target for ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiaodong Xu, Ke Zong, Xinxing Wang, Dongwei Dou, Pengwei Lv, Zhe Zhang, Hongwen Li
Summary: Aberrant expression of miR-30d in pancreatic cancer is associated with poor prognosis and early relapse of patients. The tumor suppressive effect of miR-30d is mediated through direct targeting of SOX4, leading to inhibition of the PI3K-AKT signaling pathway and repression of pancreatic cancer cell growth and metastasis.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Siou-Min Luo, Wen-Chivan Tsai, Chia-Kuang Tsai, Ying Chen, Dueng-Yuan Hueng
Summary: The study showed higher expression of ARID4B in WHO grade IV tumors, and knocking down ARID4B suppressed glioma cell proliferation and induced apoptosis, indicating that ARID4B may act as an oncogene in human gliomas.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Xuehui Wang, Hongming Song, Lin Fang, Tianqi Wu
Summary: In this study, it was found that circPRKCI, derived from the PRKCI gene, was highly expressed in TNBC and could promote the proliferation and migration of TNBC by regulating the WBP2 and PI3K/AKT signaling pathway, providing a new avenue for TNBC therapy.
CELL DEATH DISCOVERY
(2022)