The Role of Reactive Oxygen Species and Autophagy in Periodontitis and Their Potential Linkage

Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma

(2017) Zhi-Jing He et al.   FOOD AND CHEMICAL TOXICOLOGY

Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma

(2017) Gangyang Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction

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Oxygen Use in Neonatal Care: A Two-edged Sword

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Dysregulated autophagy increased melanocyte sensitivity to H2O2-induced oxidative stress in vitiligo

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Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis

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Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy

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Autophagy and its implication in human oral diseases

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Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive oxygen species scavenging by redox injectable gel suppresses alveolar bone resorption

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Autophagy Captures the Nobel Prize

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Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

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Salivary oxidative stress biomarkers in chronic periodontitis and acute coronary syndrome

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Increased visfatin expression is associated with nuclear factor-kappa B and phosphatidylinositol 3-kinase in periodontal inflammation

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Hydrogen peroxide is a central determinant of oral polymicrobial synergy

(2016) Richard J. Lamont   ENVIRONMENTAL MICROBIOLOGY

Visualization of Oxidative Stress Induced by Experimental Periodontitis in Keap1-Dependent Oxidative Stress Detector-Luciferase Mice

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Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment

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Porphyromonas gingivalisinduces autophagy in THP-1-derived macrophages

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The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction

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Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition

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Programmed cell death in periodontitis: recent advances and future perspectives

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Role of ROS and RNS Sources in Physiological and Pathological Conditions

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Effects of Porphyromonas gingivalis LipopolysaccharideTolerized Monocytes on Inflammatory Responses in Neutrophils

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Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

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Surfactin inducing mitochondria-dependent ROS to activate MAPKs, NF-κB and inflammasomes in macrophages for adjuvant activity

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Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load

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The Mucosal Immune System and Its Regulation by Autophagy

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Mitochondrial Redox Signaling and Tumor Progression

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The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry

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Modulation of inflammation by autophagy: Consequences for human disease

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FOXO responses toPorphyromonas gingivalisin epithelial cells

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Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts

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Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria

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Autophagy as a Stress Response Pathway in the Immune System

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Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cellsviaactivating ROS-TXNIP-NLRP3 inflammasome

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RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells

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Effect of Initial Periodontal Therapy on Oxidative Stress Markers in Gingival Crevicular Fluid, Saliva, and Serum in Smokers and Non-Smokers With Chronic Periodontitis

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Hyperglucose Contributes to Periodontitis: Involvement of the NLRP3 Pathway by Engaging the Innate Immunity of Oral Gingival Epithelium

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Variants ofPorphyromonas gingivalislipopolysaccharide alter lipidation of autophagic protein, microtubule-associated protein 1 light chain 3, LC3

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ATM functions at the peroxisome to induce pexophagy in response to ROS

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Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress

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A pterostilbene derivative suppresses osteoclastogenesis by regulating RANKL-mediated NFκB and MAPK signaling in RAW264.7 cells

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Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

(2015) Dinesh Thummuri et al.   PHARMACOLOGICAL RESEARCH

Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients

(2015) Ulku Baser et al.   SAUDI MEDICAL JOURNAL

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Oxidative stress and autophagy: the clash between damage and metabolic needs

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HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS–JNK–autophagy pathway

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Dual Role of Autophagy in Lipopolysaccharide-induced Preodontoblastic Cells

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Lipid Peroxidation Levels and Total Oxidant/Antioxidant Status in Serum and Saliva From Patients With Chronic and Aggressive Periodontitis. Oxidative Stress Index: A New Biomarker for Periodontal Disease?

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LPS fromP. gingivalisand Hypoxia Increases Oxidative Stress in Periodontal Ligament Fibroblasts and Contributes to Periodontitis

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Characterization of a bacterial tyrosine kinase inPorphyromonas gingivalisinvolved in polymicrobial synergy

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Pattern Recognition Receptors and Autophagy

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Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis

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Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

8-Isoprostane: A lipid peroxidation product in gingival crevicular fluid in healthy, gingivitis and chronic periodontitis subjects

(2013) A.R. Pradeep et al.   ARCHIVES OF ORAL BIOLOGY

Periodontitis and Redox Status: A Review

(2013) Luigi Nibali et al.   CURRENT PHARMACEUTICAL DESIGN

Increased Salivary Levels of 8-Hydroxydeoxyguanosine May Be a Marker for Disease Activity for Periodontitis

(2013) Ufuk Sezer et al.   DISEASE MARKERS

The role of cytokines in inflammatory bone loss

(2013) Pedro P. C. Souza et al.   IMMUNOLOGICAL INVESTIGATIONS

A periodontal pathogen Treponema denticola hijacks the Fusobacterium nucleatum -driven host response

(2013) Ji Eun Shin et al.   IMMUNOLOGY AND CELL BIOLOGY

The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling

(2013) Hiroyuki Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Antioxidant Enzymes Activity and Malondialdehyde Levels in Patients With Chronic Periodontitis and Diabetes Mellitus

(2013) Shilpa Trivedi et al.   JOURNAL OF PERIODONTOLOGY

Total Oxidant Status and Bone Resorption Biomarkers in Serum and Gingival Crevicular Fluid of Patients With Periodontitis

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Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogenPorphyromonas gingivalisduring invasion

(2013) P. Stafford et al.   Molecular Oral Microbiology

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

(2013) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study

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Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

(2013) George Hajishengallis   TRENDS IN IMMUNOLOGY

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

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Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation

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Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells

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8-Hydroxy-Deoxyguanosine Levels in Gingival Crevicular Fluid and Saliva in Patients With Chronic Periodontitis After Initial Periodontal Treatment

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Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy

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Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation

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Effects of nicotine on apoptosis in human gingival fibroblasts

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Continuously generated H2O2 stimulates the proliferation and osteoblastic differentiation of human periodontal ligament fibroblasts

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FoxOs, Wnts and oxidative stress-induced bone loss: new players in the periodontitis arena?

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Autophagy in immunity and inflammation

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Toll-like receptors and their dual role in periodontitis: a review

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Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy

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Crosstalk of reactive oxygen species and NF-κB signaling

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Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis

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Oxidative Stress, Systemic Inflammation, and Severe Periodontitis

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Butyrate, a bacterial metabolite, induces apoptosis and autophagic cell death in gingival epithelial cells

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Termination of autophagy and reformation of lysosomes regulated by mTOR

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Periodontal Disease Mechanisms: Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases

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The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis

(2009) Cenk Fatih Çanakçi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Atractylodes japonicaroot extract protects osteoblastic MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation

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Autophagy in the Pathogenesis of Disease

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