Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy

Sorafenib induces autophagic cell death and apoptosis in hepatic stellate cell through the JNK and Akt signaling pathways

(2016) Huiyao Hao et al.   ANTI-CANCER DRUGS

Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo

(2015) Mrinmay Chakrabarti et al.   APOPTOSIS

Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy

(2015) Y.-T. Tsai et al.   CANCER RESEARCH

The presence of Estrogen Receptor β modulates the response of breast cancer cells to therapeutic agents

(2015) Daniel Gabriel Pons et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine

(2015) Lili Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy

(2015) Simone Patergnani et al.   Frontiers in Oncology

Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

(2015) Miho Akimoto et al.   PLoS One

Rapamycin and Chloroquine: The In Vitro and In Vivo Effects of Autophagy-Modifying Drugs Show Promising Results in Valosin Containing Protein Multisystem Proteinopathy

(2015) Angèle Nalbandian et al.   PLoS One

Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway

(2015) Subash C. Gupta et al.   Oncotarget

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of autophagy by chloroquine potentiates synergistically anti-cancer property of artemisinin by promoting ROS dependent apoptosis

(2014) Arnab Ganguli et al.   BIOCHIMIE

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

HCC cells with high levels of Bcl-2 are resistant to ABT-737 via activation of the ROS–JNK–autophagy pathway

(2014) Zhenhong Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cucurbitacin I Induces Protective Autophagy in Glioblastomain Vitroandin Vivo

(2014) Guang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

(2014) B. Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Novel Analogue of Colchicine Induces Selective Pro-Death Autophagy and Necrosis in Human Cancer Cells

(2014) Kristen Larocque et al.   PLoS One

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

(2014) Haiyuan Zhang et al.   PLoS One

Inhibition of Autophagic Flux by Salinomycin Results in Anti-Cancer Effect in Hepatocellular Carcinoma Cells

(2014) Johannes Klose et al.   PLoS One

Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells

(2014) Eun-Ryeong Hahm et al.   PROSTATE

Recombinant Human Arginase Toxicity in Mice Is Reduced by Citrulline Supplementation

(2014) Jeremy P. Mauldin et al.   Translational Oncology

Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells

(2013) Ziyu Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Energy deprivation by silibinin in colorectal cancer cells

(2013) Komal Raina et al.   Autophagy

The Effects of Testosterone Deprivation and Supplementation on Proteasomal and Autophagy Activity in the Skeletal Muscle of the Male Mouse: Differential Effects on High-Androgen Responder and Low-Androgen Responder Muscle Groups

(2013) Carlo Serra et al.   ENDOCRINOLOGY

Autophagy contributes to ING4-induced glioma cell death

(2013) Aihua Gong et al.   EXPERIMENTAL CELL RESEARCH

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular metabolic and autophagic pathways: Traffic control by redox signaling

(2013) Matthew Dodson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species H2O2 and OH, but not O2− promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells

(2013) Linghe Zang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy Inhibition Promotes 5-Fluorouraci-Induced Apoptosis by Stimulating ROS Formation in Human Non-Small Cell Lung Cancer A549 Cells

(2013) Xiaohong Pan et al.   PLoS One

Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species

(2012) Noemi Rubio et al.   Autophagy

A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress

(2012) Virginie M.S. Betin et al.   Autophagy

Autophagy

(2012) Ricky H. Bhogal et al.   Autophagy

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oridonin: targeting programmed cell death pathways as an anti-tumour agent

(2012) Z. Liu et al.   CELL PROLIFERATION

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells

(2012) Denis Selimovic et al.   CELLULAR SIGNALLING

Autophagic tumor stroma: Mechanisms and roles in tumor growth and progression

(2012) Xianda Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy-related Gene 7 (ATG7) and Reactive Oxygen Species/Extracellular Signal-regulated Kinase Regulate Tetrandrine-induced Autophagy in Human Hepatocellular Carcinoma

(2012) Ke Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS, autophagy, mitochondria and cancer: Ras, the hidden master?

(2012) Gregory L. Bellot et al.   MITOCHONDRION

Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer

(2012) M Razandi et al.   ONCOGENE

Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells

(2012) Chang-Shen Lin et al.   ORAL ONCOLOGY

The regulation of cancer cell death and metabolism by extracellular matrix attachment

(2012) Cassandra L. Buchheit et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells

(2011) Ya-hong Zhang et al.   ACTA PHARMACOLOGICA SINICA

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

(2011) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondria removal by autophagy

(2011) Ke Wang et al.   Autophagy

Mitochondrial ROS generation for regulation of autophagic pathways in cancer

(2011) Zi-yue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemo-resistant melanoma sensitized by tamoxifen to low dose curcumin treatment through induction of apoptosis and autophagy

(2011) Sudipa June Chatterjee et al.   CANCER BIOLOGY & THERAPY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

γ-Tocotrienol Induces Apoptosis in Human T Cell Lymphoma through Activation of Both Intrinsic and Extrinsic Pathways

(2011) Chandan Wilankar et al.   CURRENT PHARMACEUTICAL DESIGN

Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

(2011) Mark J. Czaja   GASTROENTEROLOGY

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response

(2011) Anna Maria Giammarioli et al.   INTERNATIONAL JOURNAL OF CANCER

Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation

(2011) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

(2011) M Donadelli et al.   Cell Death & Disease

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

HMGB1: A novel Beclin 1-binding protein active in autophagy

(2010) Rui Kang et al.   Autophagy

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy

(2010) Spencer B. Gibson   Autophagy

Assessing autophagy in the context of photodynamic therapy

(2010) John J. Reiners et al.   Autophagy

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

A systems biology viewpoint on autophagy in health and disease

(2010) Alan Huett et al.   CURRENT OPINION IN GASTROENTEROLOGY

TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells

(2010) Deepak Mittal et al.   EMBO JOURNAL

Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells

(2010) Dong Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage

(2010) Michael Dewaele et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer

(2010) Eric E. Essick et al.   Oxidative Medicine and Cellular Longevity

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

(2010) Chew Hooi Wong et al.   PLoS One

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Peroxisomes Are Oxidative Organelles

(2009) Vasily D. Antonenkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti- and pro-tumor functions of autophagy

(2009) Eugenia Morselli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role and regulation of autophagy in cancer

(2009) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Hypoxia-induced BNIP3 expression and mitophagy: in vivo comparison of the rat and the hypoxia-tolerant mole rat, Spalax ehrenbergi

(2009) Mark Band et al.   FASEB JOURNAL

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular Responses to Cancer Chemopreventive Agent D,L-Sulforaphane in Human Prostate Cancer Cells Are Initiated by Mitochondrial Reactive Oxygen Species

(2009) Dong Xiao et al.   PHARMACEUTICAL RESEARCH

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathway

(2008) Bo Liu et al.   CANCER LETTERS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION

Toward unraveling membrane biogenesis in mammalian autophagy

(2008) Tamotsu Yoshimori et al.   CURRENT OPINION IN CELL BIOLOGY

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

(2008) Takashi Shingu et al.   INTERNATIONAL JOURNAL OF CANCER

The nuclear affairs of PTEN

(2008) S. M. Planchon et al.   JOURNAL OF CELL SCIENCE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE