Article
Cell Biology
Nan Jiang, Danqing He, Yushi Ma, Junxiang Su, Xiaowen Wu, Shengjie Cui, Zixin Li, Yanheng Zhou, Huajie Yu, Yan Liu
Summary: Mechanical force stimuli can increase the expression of the autophagy protein LC3 in periodontal ligaments, as well as the number of M1 macrophages and osteoclasts. This biological response can be repressed by the application of an autophagy inhibitor 3-methyladenine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Keren Ni, Yongmei Hua
Summary: The study showed that GYY4137 has proinflammatory effects and promotes autophagy in periodontitis, and the induced autophagy may function as a cytoprotective mechanism to prevent excessive inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Cell Biology
Wei He, Yu Fu, Song Yao, Lan Huang
Summary: The periodontal ligament consists of fibroblasts, cementoblasts, osteoblasts, osteoclasts, periodontal ligament stem cells (PDLSCs), and epithelial cell rests of Malassez. The regulation of programmed cell death is important for immune response but can also lead to the loss of periodontal supporting tissues and root resorption. These findings are relevant for understanding periodontitis and orthodontic root resorption. This comprehensive review focuses on recent studies on mechanisms of periodontal ligament cell death.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell & Tissue Engineering
Fariba Mohebichamkhorami, Roya Fattahi, Zahra Niknam, Morteza Aliashrafi, Sahar Khakpour Naeimi, Samira Gilanchi, Hakimeh Zali
Summary: Periodontal ligament stem cells (PDLSCs) have great potential for neural differentiation, capable of differentiating into various neural-like cells without the need for cell division. They can be induced towards neural lineage using a combination of nutritional factors and have significant implications for neural tissue repair when coupled with biomaterials. PDLSCs can be a valuable target for research and treatment of neurological disorders, such as Alzheimer's disease, multiple sclerosis, and cerebral ischemia. They also show beneficial effects on retinal ganglion cell regeneration and photoreceptor survival, and can be used for peripheral nerve repair through the expression of neural growth factors and differentiation into Schwann cells.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alice Blufstein, Christian Behm, Barbara Kubin, Johannes Gahn, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov
Summary: The study suggests that the transcriptional activity of VDR is reduced under inflammatory conditions, potentially diminishing the effectiveness of vitamin D(3) supplementation during periodontal treatment.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Engineering, Biomedical
Chen Zong, Wannes Van Holm, Annelies Bronckaers, Zuodong Zhao, Stevan Cokic, Merve Kubra Aktan, Ana Belen Castro, Bart Van Meerbeek, Annabel Braem, Guy Willems, Maria Cadenas de Llano-Perula
Summary: The study shows that pretreatment of human periodontal ligament stem cells (hPDLSCs) with gold nanocomplexes (AuNCs) and transplantation in a collagen hydrogel scaffold can effectively protect alveolar bone from resorption and promote bone regeneration, suggesting a promising strategy for bone defect treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Shunichi Oka, Xiaoyan Li, Fengzhu Zhang, Nitesh Tewari, Il-Shin Kim, Chongchong Chen, Liangjun Zhong, Nobushiro Hamada, Yoshiyuki Oi, Makoto Makishima, Yi Liu, Ujjal K. Bhawal
Summary: The study reveals that a deficiency in Dec1 can alter the interaction between autophagy and inflammation in PDLFs, leading to modulation of the expression levels of autophagy and inflammation-related genes, thus affecting the homeostasis of periodontal tissue.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Agnese Gugliandolo, Francesca Diomede, Jacopo Pizzicannella, Luigi Chiricosta, Oriana Trubiani, Emanuela Mazzon
Summary: This study evaluates the anti-inflammatory potential of a new lyophilized formulation of conditioned medium derived from human periodontal ligament stem cells (hPDLSCs). The lyophilized formulation was found to downregulate the expression of inflammatory genes and increase cell migration. These results suggest that lyophilization is an effective method for producing stable formulations of MSCs' secretome.
Article
Medicine, Research & Experimental
Yunhe Xu, Xiaoning Wang, Wenshu Liu, Weiwei Lu
Summary: The study revealed that thrombin-activated PRP accelerates cell viability and osteogenic differentiation of hPDLSCs via SIRT1-mediated autophagy induction.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Cell Biology
Yiping Huang, Hao Liu, Runzhi Guo, Yineng Han, Yuhui Yang, Yi Zhao, Yunfei Zheng, Lingfei Jia, Weiran Li
Summary: Orthodontic tooth movement involves periodontal tissue remodeling triggered by mechanical force, with autophagy playing a significant role in preventing damage. The study highlights the importance of lncRNA FER1L4 in regulating autophagy in PDLSCs during orthodontic treatment. FER1L4 inhibits AKT phosphorylation and promotes FOXO3 nuclear translocation, mediating autophagic cascades under compressive strain.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jiahao Zhang, Xiaohong Dong, Qianqian Yan, Wei Ren, Rui Zhang, Xinyi Jiang, Zhaoli Geng, Xinyi Xu, Chunpeng Liu, Shijie Zhang, Dongxu Liu, Yi Liu
Summary: Periodontitis is a common chronic inflammatory disease of the tooth-surrounding tissues. Gal-1 has an inhibitory effect on the development of periodontitis by regulating IL-17A expression to suppress LPS-induced cell autophagy and apoptosis.
Article
Cell & Tissue Engineering
Liya Ma, Nanquan Rao, Hui Jiang, Yuzhe Dai, Songtao Yang, Hefeng Yang, Jiangtian Hu
Summary: This study investigates the potential of DFSCs-sEVs in regenerating damaged periodontal tissue. The results show that DFSCs-sEVs promoted the proliferation, migration, and osteogenic differentiation of PDLSCs, potentially through the activation of the p38 MAPK signaling pathway. DFSCs-sEVs provide a novel strategy for periodontal regeneration.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Anatomy & Morphology
Wenbin Ge, Shitong Luo, Kun Zhang, Lizhiyi Liu, Zhi Zhou, Yali Liu
Summary: Histone deacetylases (HDACs) play important roles in post-translational modification of histones, affecting cell properties and disease progression. The role of HDAC9 in autophagy of human periodontal ligament stem cells (hPDLSCs) in an inflammatory environment and its regulatory mechanisms were investigated. Autophagy-related genes expression was upregulated when HDAC9 was inhibited, indicating that HDAC9 regulates autophagy via ERK pathways in hPDLSCs in the inflammatory environment.
Article
Medicine, Research & Experimental
Zheng Zhang, Minghui Wang, Youli Zheng, Yanmei Dai, Jiashu Chou, Xiaowei Bian, Pengcheng Wang, Changyi Li, Jing Shen
Summary: This study found that miR-223 is upregulated in periodontitis and downregulated during the osteogenesis of PDL-derived cells. Overexpression of miR-223 inhibits osteogenic differentiation of PDL-derived cells, potentially by targeting the growth factor receptor genes FGFR2 and TGFβR2.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Cell & Tissue Engineering
Aline Queiroz, Emmanuel Albuquerque-Souza, Leticia Miquelitto Gasparoni, Bruno Nunes de Franca, Cibele Pelissari, Marilia Trierveiler, Marinella Holzhausen
Summary: PDLSCs are considered a promising cell source for regenerating periodontium and have the potential to be used as an effective treatment for periodontitis.
WORLD JOURNAL OF STEM CELLS
(2021)