The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

(2009) R Terkeltaub et al.   ANNALS OF THE RHEUMATIC DISEASES

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

(2009) Kate Schroder et al.   CURRENT BIOLOGY

Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics

(2009) M. Wolfs et al.   CURRENT GENOMICS

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Interleukin-1 beta targeted therapy for type 2 diabetes

(2009) Kathrin Maedler et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

CA-074Me Protection against Anthrax Lethal Toxin

(2009) Z. L. Newman et al.   INFECTION AND IMMUNITY

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

(2008) Nadine S. Sauter et al.   ENDOCRINOLOGY

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function

(2008) Shin-ichi Oka et al.   ENDOCRINOLOGY

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

(2008) S. T. Y. Hui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE