A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Amino acid signalling upstream of mTOR

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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

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PEX5 Protein Binds Monomeric Catalase Blocking Its Tetramerization and Releases It upon Binding the N-terminal Domain of PEX14

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(2011) Changle Ma et al.   JOURNAL OF CELL BIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

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The Late Endosome is Essential for mTORC1 Signaling

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

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(2010) Li Yu et al.   NATURE

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Superoxide is the major reactive oxygen species regulating autophagy

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Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

(2009) K. Inoki et al.   HUMAN MOLECULAR GENETICS

Efficient targeting of polyhydroxybutyrate biosynthetic enzymes to plant peroxisomes requires more than three amino acids in the carboxyl-terminal signal

(2009) Kimberley Tilbrook et al.   JOURNAL OF PLANT PHYSIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

PeroxisomeDB 2.0: an integrative view of the global peroxisomal metabolome

(2009) Agatha Schlüter et al.   NUCLEIC ACIDS RESEARCH

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

A reliable cell-based assay for testing unclassified TSC2 gene variants

(2008) Ricardo Coevoets et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Tuberous sclerosis complex proteins control axon formation

(2008) Y.-J. Choi et al.   GENES & DEVELOPMENT

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE