Review
Immunology
Xiaoyu Sun, Jike Gao, Xiang Meng, Xiaoxuan Lu, Lei Zhang, Ran Chen
Summary: Macrophages play crucial roles in periodontitis, with different types impacting the immune system and the destruction and repair of periodontal tissues. Polarized M1 and M2 macrophages are involved in inflammatory and anti-inflammatory stages respectively, regulating the progression of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim
Summary: GRP modulates osteoclastogenesis by influencing the differentiation of bone marrow-derived cells, potentially contributing to the pathogenesis of periodontitis. Stimulation by P. gingivalis can enhance crosstalk between epithelial cells and bone marrow-derived cells, leading to increased osteoclast formation.
Article
Immunology
Izabel C. V. de Oliveira, Leonardo V. Galvao-Moreira, Juliana L. Vilela, Murillo Duarte-Silva, Lucas D. Aguiar-da-Silva, Cesar A. A. Pereira, Domingos M. S. Pereira, Aruana J. M. C. R. Pinheiro, Lidio G. Lima-Neto, Elizabeth S. Fernandes, Cristina R. B. Cardoso, Luciana S. Branco-de-Almeida
Summary: Cinnamaldehyde treatment reduces periodontal bone loss, attenuates inflammatory mediators, and regulates human PBMC responses, suggesting its potential therapeutic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Yeon-Hee Lee, Chon Suk, Seung-Il Shin, Ji-Youn Hong
Summary: This study aimed to investigate the neuroendocrine responses based on cortisol, dehydroepiandrosterone (DHEA), cortisol/DHEA ratio, and chromogranin A levels, which reflect the activity of the hypothalamic-pituitary-adrenal axis, according to the presence or absence of psychological stress in patients with gingivitis and periodontitis compared to that in healthy controls. The results showed that salivary cortisol and chromogranin A levels increased with the severity of periodontal disease; their levels were the highest in the periodontitis group and were significantly higher in the following descending order: periodontitis, gingivitis, and healthy control groups. Periodontitis and psychological stress were significant and strong predictors of above-average cortisol levels and cortisol/DHEA ratios.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hongying Hu, Wai Keung Leung
Summary: Periodontitis is a primary cause of tooth loss and is linked to systemic diseases. Early detection is crucial for preventing oral damage and related health complications. This study provides a systematic review of the role of proteomics in identifying salivary biomarkers for periodontitis. Nine consistently expressed candidate biomarkers were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sanjeela R. Guru, Suchetha Aghanashini
Summary: This study compared and correlated salivary and serum levels of PAI-1 and α2MG in patients with periodontitis with and without T2DM, and assessed the impact of periodontal treatment on these biomarkers. The results showed that levels of salivary and serum PAI-1 and α2MG were higher in patients with periodontitis and diabetes compared to periodontitis alone, and these biomarkers decreased after periodontal treatment. The study suggests that salivary PAI-1 could be a diagnostic biomarker and can track the response to periodontal therapy.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Isabelly Vidal do Nascimento, Maria Imaculada de Queiroz Rodrigues, Pedro Henrique Chaves Isaias, Paulo Goberlanio Barros-Silva, Fabricio Bitu Sousa, Ana Paula Negreiros Nunes Alves, Mario Rogerio Lima Mota
Summary: The study aimed to evaluate the inflammatory response and development of apical periodontitis in rats chronically treated with glucocorticoids. The results showed that glucocorticoid treatment caused an early increase in bone resorption and pulp necrosis, accompanied by alterations in cytokine levels, inflammatory response, and collagen deposition.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Endocrinology & Metabolism
Hyo Jeong Kim, Ka-Young Ryu, Yong-Gun Kim, Myoung Ok Kim, Ji Hye Lee, Min-Kyoung Song, Young-Jin Youn, Nitin Kumar Pohkrel, Sung-Hyun Kim, Jae-Young Kim, Hye-Jin Jung, Woo-Shin Kim, Chang-Won Hong, Hong-Hee Kim, Youngkyun Lee
Summary: The study revealed the crucial role of PTP1B in osteoclast differentiation, with PTP1B deficiency leading to decreased osteoclast number and activity. This highlights the potential of PTP1B as a therapeutic target for bone-lytic diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Natalie Aparecida Rodrigues Fernandes, Angelo Constantino Camilli, Laura Andrea Gonzalez Maldonado, Cindy Grace Perez Pacheco, Amanda Favoreto Silva, Rafael Scaf Molon, Luiz Carlos Spolidorio, Leticia Ribeiro de Assis, Luis Octavio Regasini, Carlos Rossa Junior, Morgana Rodrigues Guimaraes-Stabili
Summary: Chalcone T4 demonstrated anti-inflammatory effects and inhibition of bone resorption in a murine model of periodontitis and on RANKL-induced osteoclastogenesis in vitro, suggesting a potential therapeutic role in the treatment of periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
M. G. Balta, E. Papathanasiou, I. J. Blix, T. E. Van Dyke
Summary: Periodontitis is the sixth-most prevalent disease in the world and the leading cause of tooth loss in adults. Recent studies have shown that synthetic and biological disease-modifying antirheumatic drugs, such as rituximab and tocilizumab, can improve periodontal clinical parameters. Probiotics and nutritional supplements have also been found to provide anti-inflammatory benefits in the treatment of periodontitis.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. Da Ponte Leguizamon, R. S. de Molo, G. Coletto-Nunes, A. V. B. Nogueira, S. Rocha, D. M. Neo-Justino, A. Soares-Costa, P. S. Cerri, U. H. Lerner, P. P. C. Souza, J. A. Cirelli
Summary: CsinCPI-2 inhibits inflammatory processes and alveolar bone loss caused by periodontal disease, as well as directly affecting osteoclastogenesis. In mice models, CsinCPI-2 significantly reduces inflammatory cell infiltration and prevents alveolar bone loss, offering potential for periodontal disease treatment.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Wioletta Pawlukowska, Bartlomiej Baumert, Agnieszka Meller, Anna Dziewulska, Alicja Zawislak, Katarzyna Grocholewicz, Przemyslaw Nowacki, Marta Masztalewicz
Summary: Periodontal diseases and saliva stimulation can affect the severity of ischemic stroke. Stimulation of the mouth and salivary glands in patients with stroke may have a positive effect on the course of the stroke.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ying-Wu Chen, Ming-Lun Lee, Cheng-Yang Chiang, Earl Fu
Summary: This study examined the effects of Bifidobacterium and Lactobacillus on periodontitis using a rat model. The results showed that the combination of these probiotics enhanced IL-10 levels and ameliorated the symptoms of periodontitis. Single-use of probiotics also had some alleviating effects.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jorge F. Lima Teixeira, Petra Henning, Fernando A. Cintra Magalhaes, Glaucia Coletto-Nunes, Thais Floriano-Marcelino, Anna Westerlund, Sofia Moverare-Skrtic, Guilherme J. P. L. Oliveira, Ulf H. Lerner, Pedro Paulo C. Souza
Summary: This study found that interleukin-4 (IL-4) can reduce lipoprotein-induced periodontal bone loss through multiple mechanisms, including direct inhibition of osteoclast progenitors, decreased expression of osteoclast-regulating cytokines in osteoblasts, and decreased inflammation.
Article
Dentistry, Oral Surgery & Medicine
Muhanad Ali, Nathan Kucko, John A. Jansen, Fang Yang, X. Frank Walboomers
Summary: The study showed that PDLCs stimulated by LPS can significantly increase osteoclastogenesis and enhance specific gene expression, while treatment with LXA4 exhibits strong anti-inflammatory activity and can reverse these effects. This suggests that PDLCs may be a potential target for treating bacterial-induced bone resorption in patients with periodontal disease, and LXA4 is a promising candidate for such therapy.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Green & Sustainable Science & Technology
Diana Mariana Cocarta, Mariana Prodana, Ioana Demetrescu, Patricia Elena Maria Lungu, Andreea Cristiana Didilescu
Summary: Indoor air pollution, including exposure to fine particles, can have negative impacts on human health. In light of the current pandemic crisis, there is a growing need to focus on the effects of indoor pollution, particularly in dental offices.
Article
Anatomy & Morphology
C. Calin, M. Sajin, V. T. Moldovan, C. Coman, S. Stratul, A. C. Didilescu
Summary: This study investigated the expression and roles of non-collagenous extracellular matrix molecules after successful direct pulp capping through immunohistochemistry. Results showed active expression of these molecules in both soft and hard tissues during tertiary dentinogenesis, with considerable heterogeneity in methodologies and timing. Future research should focus more on human studies.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Review
Biochemistry & Molecular Biology
Mihai Andrei, Raluca Paula Vacaru, Anca Coricovac, Radu Ilinca, Andreea Cristiana Didilescu, Ioana Demetrescu
Summary: The vitality of dental pulp is essential for maintaining the health and functionality of the tooth. Hydraulic calcium-silicate cements can stimulate reparative dentinogenesis in direct pulp capping procedures, leading to the formation of new dentin bridges. Different degrees of pulp inflammatory response and dentin bridge formation were observed during pulp healing, showing positive effects on tertiary dentin formation and pulp vitality preservation.
Article
Environmental Sciences
Laura Iosif, Ana Maria Cristina Tancu, Andreea Cristiana Didilescu, Marina Imre, Bogdan Mihai Galbinasu, Radu Ilinca
Summary: The global COVID-19 pandemic has had a severe impact on dental education at Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, leading to high levels of stress and anxiety among students. The educational impact has been significant in terms of practical skills acquisition and future professional perspectives, with online learning ability being perceived as low. New dentistry teaching programs will need to be implemented to address these challenges and improve student well-being and the sustainability of dental education.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Andreea Cristiana Didilescu, Adelina Lazu, Cristian Vladan, Cristian Scheau, Laura Dan Popa, Petra Surlin, Wendy Esmeralda Kaman, Hendrik Simon Brand
Summary: This cross-sectional study aimed to explore variations of salivary markers for oral health in post-liver transplantation patients compared with systemically healthy dental outpatients. The results showed no significant differences in salivary protein and protease activity between the two groups. In the post-liver transplantation group, a positive correlation was found between salivary pH level and salivary secretion rate. With regards to self-reported oral health, there were no significant differences between the two groups except for dental and oral care habits.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Flavia Mirela Nicolae, Andreea Cristiana Didilescu, Petra Surlin, Bogdan Silviu Ungureanu, Valeriu Marin Surlin, Stefan Patrascu, Sandu Ramboiu, Igor Jelihovschi, Luminita Smaranda Iancu, Mirela Ghilusi, Mihai Cucu, Dan Ionut Gheonea
Summary: There is a possible association between the abundance of certain periopathogens in subgingival plaque and periodontal status with characteristics of gastric cancer. Fusobacterium nucleatum and Tannerella forsythia are the most abundant bacteria studied, and there is a strong correlation between tumor dimension, periodontal parameters, and the presence of F. nucleatum.
Article
Health Care Sciences & Services
Flavia Mirela Nicolae, Francesco Bennardo, Selene Barone, Petra Surlin, Dorin Nicolae Gheorghe, Daniela Burtea, Stefan Patrascu, Sandu Ramboiu, Adrian Petru Radu, Bogdan Silviu Ungureanu, Adina Turcu-Stiolica, Andreea Cristiana Didilescu, Victor Dan Eugen Strambu, Valeriu Marin Surlin, Dan Ionut Gheonea
Summary: Poor oral hygiene can lead to dental plaque accumulation and the development of periodontal disease. Local infections trigger systemic inflammatory responses, which play a crucial role in the progression of systemic diseases or cancer. Patients hospitalized with gastric cancer may neglect their oral health. This study evaluates the oral hygiene, periodontal status, and the need for medical personnel to assist in oral care for hospitalized gastric cancer patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Raluca-Paula Vacaru, Andreea Cristiana Didilescu, Ileana Constantinescu, Ion Maruntelu, Mihaela Tanase, Ioana Andreea Stanciu, Wendy Esmeralda Kaman, Hendrik Simon Brand
Summary: This study aimed to investigate the relationship between salivary enzymatic activity and carious experience in children. The findings suggest that salivary alpha-amylase and MMP-8 and MMP-9 levels may be considered potential indicators of carious experience in children.
Article
Medicine, General & Internal
Raluca-Paula Vacaru, Andreea Cristiana Didilescu, Ruxandra Sfeatcu, Mihaela Tanase, Aneta Munteanu, Daniela Miricescu, Wendy Esmeralda Kaman, Hendrik Simon Brand
Summary: This study aimed to assess dental anxiety and psychological stress induced by different types of dental treatment (prophylaxis and cavity preparation) in schoolchildren. Psychometric evaluations and salivary biomarker measurements were used. The results showed that sAA and cortisol levels responded differently to psychological stress induced by the two types of dental treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Materials Science, Multidisciplinary
Radu Nartita, Mihai Andrei, Daniela Ionita, Andreea Cristiana Didilescu, Ioana Demetrescu
Summary: This paper reviews the capability of graphene oxide (GO) coatings in preventing peri-implantitis. It establishes GO's role as a composite material in dentistry and highlights the need for further research. The main focus is on the relationship between GO and biofilm formation, as well as its efficacy in combating peri-implantitis.
Article
Medicine, General & Internal
Viorelia Radulescu, Marius Boariu, Darian Rusu, Camelia Boldeanu, Ruxandra Christodorescu, Alexandra Roman, Petra Surlin, Andreea Cristiana Didilescu, Octavia Vela, Giorgios Kardaras, Ioana Veja, Ioana Martu, Stefan-Ioan Stratul
Summary: The aim of this study was to identify patient-related factors that directly influence the long-term survival and functionality of abutment teeth in patients with Stage IV periodontitis. The study analyzed the impact of various factors on retention of dental prostheses, survival rates, and incidence of complications in patients undergoing at least 5 years of supportive periodontal therapy. The results showed significant associations between systemic diseases, tooth loss, and the type of prosthesis used.
Editorial Material
Engineering, Biomedical
Cristian Scheau, Andreea Cristiana Didilescu, Constantin Caruntu
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Medicine, General & Internal
Alexandru Eugen Petre, Mihaela Pantea, Sergiu Drafta, Marina Imre, Ana Maria Cristina Tancu, Eduard M. Liciu, Andreea Cristiana Didilescu, Silviu Mirel Pituru
Summary: A newly developed computerized method for virtual case simulation on digital dental models and 3D printing of digital models is presented. The method was well received by undergraduate dental students according to a questionnaire survey.
MEDICINA-LITHUANIA
(2023)
Article
Engineering, Biomedical
Antoanela Covaci, Lucian Toma Ciocan, Bogdan Galbinasu, Mirela Veronica Bucur, Madalina Matei, Andreea Cristiana Didilescu
Summary: This study aimed to compare the effects of different calcium-based materials on dental pulp tissue responses in deep carious lesions. The results showed that self-setting calcium hydroxide materials provided better dental pulp response. Further long-term clinical studies are needed to determine the most suitable biomaterials for vital pulp therapies.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Health Care Sciences & Services
Arina Vinereanu, Aneta Munteanu, Alexandru Stanculescu, Alexandru Titus Farcasiu, Andreea Cristiana Didilescu
Summary: This study aimed to assess the oral health status and treatment needs of intellectually challenged athletes participating in Special Olympics-Special Smiles events in Romania, and explore the potential associations with socio-economic factors. The findings revealed that Romanian Special Olympics athletes had poor oral health, limited access to dental treatment, and low level of prevention.