Mitochondrial Redox Signaling and Tumor Progression

Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss

(2015) Deug-Nam Kwon et al.   Aging-US

The paradoxical role of thioredoxin on oxidative stress and aging

(2015) Geneva M. Cunningham et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

(2015) O. Canli et al.   BLOOD

Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

(2015) Lingtao Jin et al.   CANCER CELL

Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma

(2015) L. P. M. P. Hemachandra et al.   CANCER RESEARCH

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function

(2015) Q. Huang et al.   CIRCULATION

Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells

(2015) E E Fink et al.   LEUKEMIA

Data standards can boost metabolomics research, and if there is a will, there is a way

(2015) Philippe Rocca-Serra et al.   Metabolomics

Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death

(2015) B Schenk et al.   ONCOGENE

Redox proteomics: Methods for the identification and enrichment of redox-modified proteins and their applications

(2015) Claudia Lennicke et al.   PROTEOMICS

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Redox mechanisms of cardiomyocyte mitochondrial protection

(2015) Raquel R. Bartz et al.   Frontiers in Physiology

Novel Action and Mechanism of Auranofin in Inhibition of Vascular Endothelial Growth Factor Receptor-3-Dependent Lymphangiogenesis

(2014) Xiaodong Chen et al.   Anti-Cancer Agents in Medicinal Chemistry

Plasma Antioxidants, Genetic Variation in SOD2, CAT, GPX1, GPX4, and Prostate Cancer Survival

(2014) E. L. Van Blarigan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions

(2014) Ryan J. Mailloux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging dynamic redox processes with genetically encoded probes

(2014) Daria Ezeriņa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Carbamoylating Activity Associated with the Activation of the Antitumor Agent Laromustine Inhibits Angiogenesis by Inducing ASK1-Dependent Endothelial Cell Death

(2014) Weidong Ji et al.   PLoS One

Is Cancer a Metabolic Disease?

(2013) Hilary A. Coller   AMERICAN JOURNAL OF PATHOLOGY

Does Scavenging of Mitochondrial Superoxide Attenuate Cancer Prosurvival Signaling Pathways?

(2013) Rafal R. Nazarewicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetically encoded fluorescent redox sensors

(2013) Konstantin A. Lukyanov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cancer as a metabolic disease: implications for novel therapeutics

(2013) T. N. Seyfried et al.   CARCINOGENESIS

Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells

(2013) Toshio Inoue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hallmarks of a new era in mitochondrial biochemistry

(2013) D. J. Pagliarini et al.   GENES & DEVELOPMENT

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

(2013) Aniruddha Sengupta et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Single-nucleotide polymorphisms of GPX1 and MnSOD and susceptibility to bladder cancer: a systematic review and meta-analysis

(2013) Ming Cao et al.   TUMOR BIOLOGY

Manganese superoxide dismutase regulation and cancer

(2012) Sanjit Kumar Dhar et al.   FREE RADICAL BIOLOGY AND MEDICINE

New components of the necroptotic pathway

(2012) Zhenru Zhou et al.   Protein & Cell

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine

(2011) J.S. Murley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Vertebrate-specific glutaredoxin is essential for brain development

(2011) L. Brautigam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

(2010) Jean-Pierre Bayley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress Inhibits Vascular KATPChannels byS-Glutathionylation

(2010) Yang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Glutaredoxin Regulates Apoptosis in Cardiomyocytes via NFκB Targets Bcl-2 and Bcl-xL: Implications for Cardiac Aging

(2009) Molly M. Gallogly et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial-Specific Expression of Mitochondrial Thioredoxin Promotes Ischemia-Mediated Arteriogenesis and Angiogenesis

(2009) Shengchuan Dai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glutathione Peroxidase-1 Regulates Mitochondrial Function to Modulate Redox-dependent Cellular Responses

(2009) Diane E. Handy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Attenuation of doxorubicin-induced cardiac injury by mitochondrial glutaredoxin 2

(2008) Nicole M. Diotte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit

(2008) Thomas R. Hurd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins

(2008) M. Benhar et al.   SCIENCE

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

(2007) Viviana I. Pérez et al.   FREE RADICAL BIOLOGY AND MEDICINE

NF-κB-mediated adaptive resistance to ionizing radiation

(2007) Kazi Mokim Ahmed et al.   FREE RADICAL BIOLOGY AND MEDICINE