RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1

(2016) Mehul Sharma et al.   FEBS Journal

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

(2016) Christian K. Holm et al.   Nature Communications

Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients

(2016) Caroline Petitdemange et al.   PLoS Neglected Tropical Diseases

IL-1 Contributes to the Anti-Cancer Efficacy of Ingenol Mebutate

(2016) Thuy T. Le et al.   PLoS One

Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism

(2015) Clément d’Audigier et al.   ANGIOGENESIS

Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells

(2015) A. C. Vrazo et al.   BLOOD

Emergence and potential for spread of Chikungunya virus in Brazil

(2015) Marcio Roberto Teixeira Nunes et al.   BMC Medicine

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress

(2015) Julie M. Fox et al.   CELL

Interferon-inducible GTPases in cell autonomous and innate immunity

(2015) Etienne Meunier et al.   CELLULAR MICROBIOLOGY

From Multiple PAR1 Receptor/Protein Interactions to their Multiple Therapeutic Implications

(2015) Marta Gutierrez-Rodriguez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts

(2015) Peeraya Ekchariyawat et al.   INFECTION GENETICS AND EVOLUTION

Control of immunopathology during chikungunya virus infection

(2015) Caroline Petitdemange et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CRTAM determines the CD4+cytotoxic T lymphocyte lineage

(2015) Arata Takeuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chikungunya virus non-structural protein 2-mediated host shut-off disables the unfolded protein response

(2015) Jelke J. Fros et al.   JOURNAL OF GENERAL VIROLOGY

Granzymes Regulate Proinflammatory Cytokine Responses

(2015) Annette C. Wensink et al.   JOURNAL OF IMMUNOLOGY

A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection

(2015) Terk-Shin Teng et al.   JOURNAL OF INFECTIOUS DISEASES

Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology

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The Phosphatidylserine and Phosphatidylethanolamine Receptor CD300a Binds Dengue Virus and Enhances Infection

(2015) Xavier Carnec et al.   JOURNAL OF VIROLOGY

Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial

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French guidelines for the management of chikungunya (acute and persistent presentations). November 2014

(2015) F. Simon et al.   MEDECINE ET MALADIES INFECTIEUSES

Chikungunya Virus and the Global Spread of a Mosquito-Borne Disease

(2015) Scott C. Weaver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dengue virus infection elicits highly polarized CX3CR1+cytotoxic CD4+T cells associated with protective immunity

(2015) Daniela Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

(2015) Jessica L. Grieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating the burden of disease and the economic cost attributable to chikungunya, Colombia, 2014

(2015) Jaime A. Cardona-Ospina et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Chikungunya Virus Pathogenesis and Immunity

(2015) Philippe Gasque et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Division of labor between IRF1 and IRF2 in regulating different stages of transcriptional activation in cellular antiviral activities

(2015) Gang Ren et al.   Cell and Bioscience

High Rate of Subclinical Chikungunya Virus Infection and Association of Neutralizing Antibody with Protection in a Prospective Cohort in The Philippines

(2015) In-Kyu Yoon et al.   PLoS Neglected Tropical Diseases

Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation

(2015) Suan-Sin Foo et al.   PLoS Pathogens

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

(2015) Josephine M. Reynaud et al.   PLoS Pathogens

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

(2015) Tina M. Sali et al.   PLoS Pathogens

The Complex Role of STAT3 in Viral Infections

(2015) Suresh V. Kuchipudi   Journal of Immunology Research

Infectious Chikungunya Virus in the Saliva of Mice, Monkeys and Humans

(2015) Joy Gardner et al.   PLoS One

Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature

(2014) Jamshaid Ahmad et al.   BIOLOGICAL CHEMISTRY

Granzyme B Promotes Cytotoxic Lymphocyte Transmigration via Basement Membrane Remodeling

(2014) Monica D. Prakash et al.   IMMUNITY

Identification of Serpinb6b as a Species-specific Mouse Granzyme A Inhibitor Suggests Functional Divergence between Human and Mouse Granzyme A

(2014) Dion Kaiserman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD8+T Cells Control Ross River Virus Infection in Musculoskeletal Tissues of Infected Mice

(2014) Kristina S. Burrack et al.   JOURNAL OF IMMUNOLOGY

Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING

(2014) Jeonghyun Ahn et al.   JOURNAL OF IMMUNOLOGY

Correlation of plasma viral loads and presence of Chikungunya IgM antibodies with cytokine/chemokine levels during acute Chikungunya virus infection

(2014) Vijayalakshmi Reddy et al.   JOURNAL OF MEDICAL VIROLOGY

Substrate Specificities of the Granzyme Tryptases A and K

(2014) Kim Plasman et al.   JOURNAL OF PROTEOME RESEARCH

Prime-Boost Immunization Strategies against Chikungunya Virus

(2014) D. Hallengard et al.   JOURNAL OF VIROLOGY

Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

(2014) D. Olagnier et al.   JOURNAL OF VIROLOGY

CCR2 Deficiency Promotes Exacerbated Chronic Erosive Neutrophil-Dominated Chikungunya Virus Arthritis

(2014) Y. S. Poo et al.   JOURNAL OF VIROLOGY

A Novel Poxvirus-Based Vaccine, MVA-CHIKV, Is Highly Immunogenic and Protects Mice against Chikungunya Infection

(2014) J. Garcia-Arriaza et al.   JOURNAL OF VIROLOGY

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

(2014) Weiqiang Chen et al.   JOURNAL OF VIROLOGY

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial

(2014) Lee-Jah Chang et al.   LANCET

Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes

(2014) A. C. Wensink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis

(2014) Maykel A. Arias et al.   Cell Reports

Granzyme A Produces Bioactive IL-1β through a Nonapoptotic Inflammasome-Independent Pathway

(2014) Dagmar Hildebrand et al.   Cell Reports

Multiple Immune Factors Are Involved in Controlling Acute and Chronic Chikungunya Virus Infection

(2014) Yee Suan Poo et al.   PLoS Neglected Tropical Diseases

Are all granzymes cytotoxic in vivo?

(2013) Lars T. Joeckel et al.   BIOLOGICAL CHEMISTRY

Finding the active genes in deep RNA-seq gene expression studies

(2013) Traver Hart et al.   BMC GENOMICS

Neutralizing monoclonal antibodies to the E2 protein of chikungunya virus protects against disease in a mouse model

(2013) Lucas Y.H. Goh et al.   CLINICAL IMMUNOLOGY

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

(2013) HyeonJoo Cheon et al.   EMBO JOURNAL

An Essential Role of Antibodies in the Control of Chikungunya Virus Infection

(2013) F.-M. Lum et al.   JOURNAL OF IMMUNOLOGY

C-type lectin receptor Clec4d plays a protective role in resolution of Gram-negative pneumonia

(2013) Anthony L. Steichen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model

(2013) Laetitia Aerts et al.   PLoS One

Mice Deficient in Interferon-Gamma or Interferon-Gamma Receptor 1 Have Distinct Inflammatory Responses to Acute Viral Encephalomyelitis

(2013) Eun-Young Lee et al.   PLoS One

Identical Strength of the T Cell Responses against E2, nsP1 and Capsid CHIKV Proteins in Recovered and Chronic Patients after the Epidemics of 2005-2006 in La Reunion Island

(2013) Jean-Jacques Hoarau et al.   PLoS One

Cytokine levels in patients with chikungunya virus infection

(2013) Chintana Chirathaworn et al.   Asian Pacific Journal of Tropical Medicine

A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease

(2013) Suganya Selvarajah et al.   PLoS Neglected Tropical Diseases

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

(2013) Helen M. Lazear et al.   PLoS Pathogens

Molecular Mechanisms Involved in the Pathogenesis of Alphavirus-Induced Arthritis

(2013) Iranaia Assunção-Miranda et al.   Biomed Research International

Effectiveness of Chloroquine and Inflammatory Cytokine Response in Patients With Early Persistent Musculoskeletal Pain and Arthritis Following Chikungunya Virus Infection

(2013) Arvind Chopra et al.   Arthritis & Rheumatology

Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis

(2012) Helder I. Nakaya et al.   ARTHRITIS AND RHEUMATISM

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(2012) M. Kearse et al.   BIOINFORMATICS

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

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(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

(2012) Yiu-Wing Kam et al.   EMBO Molecular Medicine

Viperin restricts chikungunya virus replication and pathology

(2012) Terk-Shin Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice

(2012) T.-H. Teo et al.   JOURNAL OF IMMUNOLOGY

Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

(2012) Penny A. Rudd et al.   JOURNAL OF VIROLOGY

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

(2012) Maroof Hasan et al.   NATURE IMMUNOLOGY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Arthritogenic alphaviruses—an overview

(2012) Andreas Suhrbier et al.   Nature Reviews Rheumatology

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate

(2012) Christina L. Gardner et al.   VIROLOGY

HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production

(2011) A. N. Harman et al.   BLOOD

GC-Content Normalization for RNA-Seq Data

(2011) Davide Risso et al.   BMC BIOINFORMATICS

Mouse granzyme K has pro-inflammatory potential

(2011) L T Joeckel et al.   CELL DEATH AND DIFFERENTIATION

Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study

(2011) A. CHOPRA et al.   EPIDEMIOLOGY AND INFECTION

A Novel and Divergent Role of Granzyme A and B in Resistance to Helminth Infection

(2011) W. Hartmann et al.   JOURNAL OF IMMUNOLOGY

Analysis of Intrahost Variation in Venezuelan Equine Encephalitis Virus Reveals Repeated Deletions in the 6-Kilodalton Protein Gene

(2011) N. L. Forrester et al.   JOURNAL OF VIROLOGY

High concentrations of circulating interleukin-6 and monocyte chemotactic protein-1 with low concentrations of interleukin-8 were associated with severe chikungunya fever during the 2009-2010 outbreak in Thailand

(2011) Jindarat Lohachanakul et al.   MICROBIOLOGY AND IMMUNOLOGY

Arbovirus high fidelity variant loses fitness in mosquitoes and mice

(2011) L. L. Coffey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis

(2011) Danher Wang et al.   VACCINE

Role of Proinflammatory Cytokines and Chemokines in Chronic Arthropathy in CHIKV Infection

(2011) Itta Krishna Chaaithanya et al.   VIRAL IMMUNOLOGY

ISG15 Is Critical in the Control of Chikungunya Virus Infection Independent of UbE1L Mediated Conjugation

(2011) Scott W. Werneke et al.   PLoS Pathogens

Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity

(2011) Caroline Petitdemange et al.   PLoS Pathogens

Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis

(2010) Ali Zaid et al.   ARTHRITIS AND RHEUMATISM

Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

(2010) Karine Labadie et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

(2010) Clémentine Schilte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

(2010) D. A. Anthony et al.   JOURNAL OF IMMUNOLOGY

Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

(2010) J. J. Hoarau et al.   JOURNAL OF IMMUNOLOGY

The Acute Phase of Chikungunya Virus Infection in Humans Is Associated With Strong Innate Immunity and T CD8 Cell Activation

(2010) Nadia Wauquier et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Arthralgia Induced by Chikungunya Virus Infection is Associated with Interleukin-6 and Granulocyte Macrophage Colony-Stimulating Factor

(2010) Angela Chow et al.   JOURNAL OF INFECTIOUS DISEASES

Chikungunya Virus Arthritis in Adult Wild-Type Mice

(2010) J. Gardner et al.   JOURNAL OF VIROLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Biases in Illumina transcriptome sequencing caused by random hexamer priming

(2010) Kasper D. Hansen et al.   NUCLEIC ACIDS RESEARCH

Nanopatch-Targeted Skin Vaccination against West Nile Virus and Chikungunya Virus in Mice

(2010) Tarl W. Prow et al.   Small

Serum IL-18 and IL-18BP Levels in Patients with Chikungunya Virus Infection

(2010) Chintana Chirathaworn et al.   VIRAL IMMUNOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Adiponectin Inhibits Pro-inflammatory Signaling in Human Macrophages Independent of Interleukin-10

(2009) Eduardo J. Folco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncytolytic Clearance of Sindbis Virus Infection from Neurons by Gamma Interferon Is Dependent on Jak/Stat Signaling

(2009) R. Burdeinick-Kerr et al.   JOURNAL OF VIROLOGY

The immunobiology of viral arthritides

(2009) Andreas Suhrbier et al.   PHARMACOLOGY & THERAPEUTICS

IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity

(2009) Lisa F. P. Ng et al.   PLoS One

Granule-associated serine proteases: granzymes might not just be killer proteases

(2009) Christopher J. Froelich et al.   TRENDS IN IMMUNOLOGY

The Transcriptome of Human Cytotoxic T Cells: Similarities and Disparities Among Allostimulated CD4+CTL, CD8+CTL and NK cells

(2008) L. G. Hidalgo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams

(2008) Tim Hulsen et al.   BMC GENOMICS

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Host responses to alphavirus infection

(2008) Kate D. Ryman et al.   IMMUNOLOGICAL REVIEWS

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1–dependent leukocyte recruitment in vivo

(2008) Daxin Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage‐Derived Proinflammatory Factors Contribute to the Development of Arthritis and Myositis after Infection with an Arthrogenic Alphavirus

(2008) Brett A. Lidbury et al.   JOURNAL OF INFECTIOUS DISEASES

Complement Receptor 3 Promotes Severe Ross River Virus-Induced Disease

(2008) T. E. Morrison et al.   JOURNAL OF VIROLOGY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

(2008) Thérèse Couderc et al.   PLoS Pathogens