Article
Biology
Jing Zhao, Siyuan Gao, Yanli Guo, Qinglei Xu, Mingzheng Liu, Chunlei Zhang, Meng Cheng, Xianle Zhao, Allan P. Schinckel, Bo Zhou
Summary: This study evaluated the impact of the dopamine receptor D2 gene on aggressive behavior in pigs and identified a functional single-nucleotide polymorphism that affects the binding of transcriptional factors. The findings shed light on the genetics and neurophysiology of aggressive behavior in pigs, providing insight towards controlling this behavior.
Article
Fisheries
Xiaojuan Chen, Yanyun Guan, Kexin Li, Tian Luo, Yinnan Mu, Xinhua Chen
Summary: In this study, it was found that both LcIRF1 and LcIRF2 play important roles in the antiviral response of large yellow croaker by inducing distinct subgroups of type I interferons.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hao Zhou, Yan-Dong Tang, Chunfu Zheng
Summary: This article summarizes recent advances in IRF1 research and highlights its potential roles in initiating interferon immune responses and antiviral responses. The challenges regarding IRF7-mediated interferon positive feedback during infection are discussed, and a revised model is proposed to decipher the functional roles of IRF1 in antiviral immunity.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Microbiology
Hui Feng, Yi-Bing Zhang, Jian-Fang Gui, Stanley M. Lemon, Daisuke Yamane
Summary: IRF1, a key nuclear factor, not only activates interferon genes, but also regulates host defense against invading pathogens. Conserved in vertebrates, IRF1 plays an important role in combating viral infections.
Article
Immunology
Eva Persyn, Sigrid Wahlen, Laura Kiekens, Wouter Van Loocke, Hannah Siwe, Els Van Ammel, Zenzi De Vos, Filip Van Nieuwerburgh, Patrick Matthys, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Summary: IRF2 plays an important role in the differentiation and functional maturation of human NK cells. Its expression levels directly affect cell numbers and functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeremie Rosain, Anna-Lena Neehus, Jeremy Manry, Rui Yang, Jeremie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Ozden Turel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M. Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guerin, Paul Bastard, Marcela Moncada-Velez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake, Barbara C. Mindt, Laura Perez, Quentin Philippot, Danyel Lee, Peng Zhang, Darawan Rinchai, Fatima Al Ali, Manar Mahmoud Ahmad Ata, Mahbuba Rahman, Jessica N. Peel, Soren Heissel, Henrik Molina, Yasemin Kendir-Demirkol, Rasheed Bailey, Shuxiang Zhao, Jonathan Bohlen, Mathieu Mancini, Yoann Seeleuthner, Marie Roelens, Lazaro Lorenzo, Camille Soudee, Maria Elvira Josefina Paz, Maria Laura Gonzalez, Mohamed Jeljeli, Jean Soulier, Serge Romana, Anne-Sophie L'Honneur, Marie Materna, Ruben Martinez-Barricarte, Mathieu Pochon, Carmen Oleaga-Quintas, Alexandre Michev, Melanie Migaud, Romain Levy, Marie-Alexandra Alyanakian, Flore Rozenberg, Carys A. Croft, Guillaume Vogt, Jean-Francois Emile, Laurent Kremer, Cindy S. Ma, Jorg H. Fritz, Stanley M. Lemon, Andras N. Spaan, Nicolas Manel, Laurent Abel, Margaret R. MacDonald, Stephanie Boisson-Dupuis, Nico Marr, Stuart G. Tangye, James P. Di Santo, Qian Zhang, Shen-Ying Zhang, Charles M. Rice, Vivien Beziat, Nico Lachmann, David Langlais, Jean-Laurent Casanova, Philippe Gros, Jacinta Bustamante
Summary: Inborn errors of IFN-g-dependent macrophagic immunity cause mycobacterial diseases, while inborn errors of IFN-a/b-dependent intrinsic immunity lead to viral diseases. Children with complete IRF1 deficiency have early-onset, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. Their IFN-a/b-dependent antiviral immunity is largely normal, but their IFN-g-dependent macrophagic immunity is impaired.
Article
Virology
Yu Han, Xue Bai, Siying Liu, Jingfei Zhu, Fan Zhang, Lifen Xie, Guodi Liu, Xiaohui Jiang, Mingchao Zhang, Yingkang Huang, Jingfeng Wang, Dapei Li, Huiying Zhang, Yuanqing He, Sudan He, Yu Xia, Xiulong Xu, Feng Xu, Feng Ma
Summary: This study reveals the crucial role of XAF1 in enhancing interferon-induced apoptosis and combating RNA virus infections. XAF1 stabilizes IRF1 protein and induces the expression of antiviral genes, thereby strengthening the host's antiviral innate immunity.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Wenji Huang, Xin Zhao, Ning Ji, Jiahong Guo, Jianhua Feng, Kangyong Chen, Yaxin Wu, Junya Wang, Hao Feng, Jun Zou
Summary: Interferon regulatory factor 2a (IRF2a) inhibits interferon response and promotes virus replication in zebrafish. Its suppressive effects are enhanced by the phosphoprotein of spring viremia of carp virus (SVCV) through inhibition of K48-linked ubiquitination of IRF2a. IRF2a and SVCV-P cooperate to degrade STAT1 and block its nuclear translocation. Our study demonstrates that viruses target IRFs and STATs through posttranslational modifications to suppress interferon-mediated antiviral response in lower vertebrates.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Bongwoo Kim, Yi Luo, Xiaoming Zhan, Zilai Zhang, Xuanming Shi, Jiaqing Yi, Zhenyu Xuan, Jiang Wu
Summary: The core subunit BRG1 of the SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes regulates neuronal activity-induced enhancers by affecting enhancer activities and inducibility. BRG1 phosphorylation induced by neuronal stimulations modulates its interaction with transcription co-factors, potentially influencing transcription outcomes. Non-phosphorylatable BRG1 fails to efficiently induce activity-dependent genes, while phosphomimic BRG1 increases enhancer activity and inducibility.
Review
Biochemistry & Molecular Biology
Yuxin Fu, Ate H. Jaarsma, Oscar P. Kuipers
Summary: The research on RiPPs has shown significant potential in the field of antiviral therapy, with advantages in specificity, stability, and cellular penetrability. RiPPs may offer innovative solutions to the limitations of current antiviral treatments and hold promise as potent candidates for antiviral drugs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Fisheries
Aleksandra H. Crossman, Eric. H. Ignatz, Jennifer. R. Hall, Surendra Kumar, Mark. D. Fast, Khalil Eslamloo, Matthew. L. Rise
Summary: Atlantic salmon is an economically important aquaculture species, but disease poses a significant threat to the industry. The study focuses on understanding the genes and molecular pathways involved in the immune responses of Atlantic salmon, which is crucial for breeding disease-resistant broodstock and developing effective mitigation strategies.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Simon Loevenich, Alix S. Spahn, Kristin Rian, Victor Boyartchuk, Marit Walbye Anthonsen
Summary: Viral infection induces the regulation of IRF1 expression through TBK1 and IFN-β via the NF-κB signaling pathway, and in later stages of infection, it heavily relies on IFN-β-mediated signaling through the IFNAR-STAT1 pathway. This mechanism's discovery is relevant not only to defense against HMPV, but also to other viral, bacterial, and fungal pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Katherine A. Giles, Cathryn M. Gould, Joanna Achinger-Kawecka, Scott G. Page, Georgia R. Kafer, Samuel Rogers, Phuc-Loi Luu, Anthony J. Cesare, Susan J. Clark, Phillippa C. Taberlay
Summary: The study found that BRG1 is overexpressed in prostate cancer and mainly affects global transcription programs by down-regulating gene expression, with most downregulated genes related to proliferation. Depletion of BRG1 results in G1 arrest.
CLINICAL EPIGENETICS
(2021)
Article
Biochemical Research Methods
Maria Osmala, Gokcen Eraslan, Harri Lahdesmaki
Summary: ChromDMM is a mixture model based on multiple chromatin features, which accurately clusters genomic regions and discovers distinctive patterns of epigenetic signals at regulatory elements. Validated with simulated data and ENCODE data, ChromDMM demonstrates higher accuracy and robustness.
Article
Immunology
Lasse van Wijlick, Sadri Znaidi, Arturo Hernandez-Cervantes, Virginia Basso, Sophie Bachellier-Bassi, Christophe d'Enfert
Summary: The alternate growth of Candida albicans between yeast and hyphal forms is crucial for its pathogenicity. The transcription factor Orf19.217 plays an important role in regulating hyphal morphogenesis and iron acquisition. Orf19.217-mediated filamentation is distinct from a true hyphal program.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Zhiqiang Zhang, Kun Xu, Ying Xin, Zhiying Zhang
ANALYTICAL BIOCHEMISTRY
(2015)
Article
Biochemical Research Methods
Lijun Guo, Kun Xu, Zhiyuan Liu, Cunfang Zhang, Ying Xin, Zhiying Zhang
ANALYTICAL BIOCHEMISTRY
(2015)
Article
Biochemical Research Methods
Kun Xu, Tingting Zhang, Lijun Guo, Ying Xin, Long Zhang, Zhiying Zhang
ANALYTICAL BIOCHEMISTRY
(2015)
Correction
Biochemistry & Molecular Biology
Chonghua Ren, Kun Xu, Zhongtian Liu, Juncen Shen, Furong Han, Zhilong Chen, Zhiying Zhang
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Article
Biochemistry & Molecular Biology
Chonghua Ren, Kun Xu, Zhongtian Liu, Juncen Shen, Furong Han, Zhilong Chen, Zhiying Zhang
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Article
Fisheries
Nana Yan, Kun Xu, Xinyi Li, Yuwan Liu, Yichun Bai, Xiaohan Zhang, Baoquan Han, Zhilong Chen, Zhiying Zhang
FISH & SHELLFISH IMMUNOLOGY
(2015)
Article
Immunology
Zhongtian Liu, Gang Zhou, Chonghua Ren, Kun Xu, Qiang Yan, Xinyi Li, Tingting Zhang, Zhiying Zhang
Article
Genetics & Heredity
Yichun Bai, Linjie He, Pengcheng Li, Kun Xu, Simin Shao, Chonghua Ren, Zhongtian Liu, Zehui Wei, Zhiying Zhang
G3-GENES GENOMES GENETICS
(2016)
Article
Biochemistry & Molecular Biology
Gang Ren, Wenfei Jin, Kairong Cui, Joseph Rodrigez, Gangqing Hu, Zhiying Zhang, Daniel R. Larson, Keji Zhao
Article
Biochemical Research Methods
Binbin Lai, Qingsong Tang, Wenfei Jin, Gangqing Hu, Darawalee Wangsa, Kairong Cui, Benjamin Z. Stanton, Gang Ren, Yi Ding, Ming Zhao, Shuai Liu, Jiuzhou Song, Thomas Ried, Keji Zhao
Article
Biochemistry & Molecular Biology
Joseph Rodriguez, Gang Ren, Christopher R. Day, Keji Zhao, Carson C. Chow, Daniel R. Larson
Article
Immunology
Christelle Harly, Devin Kenney, Gang Ren, Binbin Lai, Tobias Raabe, Qi Yang, Margaret C. Cam, Hai-Hui Xue, Keji Zhao, Avinash Bhandoola
Review
Biochemistry & Molecular Biology
Gang Ren, Keji Zhao
CELL AND BIOSCIENCE
(2019)
Article
Hematology
Tao Zhen, Yaqiang Cao, Gang Ren, Ling Zhao, R. Katherine Hyde, Guadalupe Lopez, Dechun Feng, Lemlem Alemu, Keji Zhao, P. Paul Liu
Article
Immunology
Gang Ren, Binbin Lai, Christelle Harly, Songjoon Baek, Yi Ding, Mingzhu Zheng, Yaqiang Cao, Kairong Cui, Yu Yang, Jinfang Zhu, Gordon L. Hager, Avinash Bhandoola, Keji Zhao
Summary: The differentiation of innate lymphoid cells (ILCs) from hematopoietic stem cells requires the progression through several multipotent progenitor stages. This study shows that there are distinct accessible chromatin regions in all lymphoid progenitors (ALPs), early ILC precursors (EILPs), and ILC precursors (ILCPs). Single-cell MNase-seq analyses reveal that EILPs contain subpopulations epigenetically primed toward dendritic cell or ILC lineages. Key transcription factors TCF-1 and GATA3 are found to be indispensable for the epigenetic priming of lineage-defining sites for ILCs at the EILP stage.