Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon

(2013) Jenish R Patel et al.   EMBO REPORTS

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Characterization of Synthetic Chikungunya Viruses Based on the Consensus Sequence of Recent E1-226V Isolates

(2013) Florine E. M. Scholte et al.   PLoS One

Viperin Is Induced following Dengue Virus Type-2 (DENV-2) Infection and Has Anti-viral Actions Requiring the C-terminal End of Viperin

(2013) Karla J. Helbig et al.   PLoS Neglected Tropical Diseases

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

(2013) Marie-Line Goulet et al.   PLoS Pathogens

Viperin restricts chikungunya virus replication and pathology

(2012) Terk-Shin Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

Intranasal Treatment with Poly(I{middle dot}C) Protects Aged Mice from Lethal Respiratory Virus Infections

(2012) J. Zhao et al.   JOURNAL OF VIROLOGY

A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant

(2012) L. Martínez-Gil et al.   JOURNAL OF VIROLOGY

Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells

(2012) Yong-Gang Li et al.   Virology Journal

Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages

(2012) Liudmila Mazaleuskaya et al.   Viruses-Basel

Innate Immunity Evasion by Dengue Virus

(2012) Juliet Morrison et al.   Viruses-Basel

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

(2012) Sebastian Aguirre et al.   PLoS Pathogens

CpG and poly(I:C) stimulation of dendritic cells and fibroblasts limits herpes simplex virus type 1 infection in an IFNβ-dependent and -independent way

(2011) Giel R. Gaajetaan et al.   ANTIVIRAL RESEARCH

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

(2011) S Mehdi Belgnaoui et al.   CURRENT OPINION IN IMMUNOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

(2011) Sun-Young Hwang et al.   NUCLEIC ACIDS RESEARCH

Decreased Dengue Replication and an Increased Anti-viral Humoral Response with the use of Combined Toll-Like Receptor 3 and 7/8 Agonists in Macaques

(2011) Carlos A. Sariol et al.   PLoS One

Activation of Toll-Like Receptor 3 Impairs the Dengue Virus Serotype 2 Replication through Induction of IFN-β in Cultured Hepatoma Cells

(2011) Zhaoduan Liang et al.   PLoS One

Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells

(2011) Stefan W Metz et al.   Virology Journal

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

(2011) A. M. A. Nasirudeen et al.   PLoS Neglected Tropical Diseases

IFN-α and IFN-λ differ in their antiproliferative effects and duration of JAK/STAT signaling activity

(2010) Stephen G. Maher et al.   CANCER BIOLOGY & THERAPY

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Recognition of viruses by cytoplasmic sensors

(2010) Courtney Wilkins et al.   CURRENT OPINION IN IMMUNOLOGY

New developments in the induction and antiviral effectors of type I interferon

(2010) Su-Yang Liu et al.   CURRENT OPINION IN IMMUNOLOGY

A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages

(2010) Yu Zhou et al.   IMMUNOLOGY

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

(2010) Clémentine Schilte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of the Type I Interferon Response in Human Dendritic Cells by Dengue Virus Infection Requires a Catalytically Active NS2B3 Complex

(2010) J. R. Rodriguez-Madoz et al.   JOURNAL OF VIROLOGY

Biology and pathogenesis of chikungunya virus

(2010) Olivier Schwartz et al.   NATURE REVIEWS MICROBIOLOGY

RIGorous Detection: Exposing Virus Through RNA Sensing

(2010) J. Rehwinkel et al.   SCIENCE

Activation of the innate immune system provides broad-spectrum protection against influenza A viruses with pandemic potential in mice

(2010) Yuk-Fai Lau et al.   VIROLOGY

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Activation of Interferon Response Through Toll-Like Receptor 3 Impacts Viral Pathogenesis and Pulmonary Toll-Like Receptor Expression During Respiratory Syncytial Virus and Influenza Infections in the Cotton Rat Sigmodon hispidus Model

(2009) Marina S. Boukhvalova et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Chikungunya: a bending reality

(2009) Zhisheng Her et al.   MICROBES AND INFECTION

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

(2009) Anne S Dejean et al.   NATURE IMMUNOLOGY

Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA

(2009) S. Myong et al.   SCIENCE

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G

(2008) S. Trapp et al.   JOURNAL OF VIROLOGY

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

(2008) Thérèse Couderc et al.   PLoS Pathogens