Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

Protease-activated receptor-1 cleaved at R46 mediates cytoprotective effects

(2012) R. A. SCHUEPBACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A new era of GPCR structural and chemical biology

(2012) Sébastien Granier et al.   Nature Chemical Biology

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Vorapaxar in the Secondary Prevention of Atherothrombotic Events

(2012) David A. Morrow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

(2012) R. Rahmeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Cytoprotective-Selective Activated Protein C AttenuatesPseudomonas aeruginosa–Induced Lung Injury in Mice

(2011) Nastasha Bir et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein–Coupled Receptors

(2011) Celine Valant et al.   Annual Review of Pharmacology and Toxicology

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Biased Ligands for Better Cardiovascular Drugs

(2011) Scott M. DeWire et al.   CIRCULATION RESEARCH

Multiple receptor-mediated functions of activated protein C

(2011) H. Weiler   Hamostaseologie

Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury

(2011) Georgios Koukos et al.   IUBMB LIFE

The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases

(2011) Alireza R. Rezaie   IUBMB LIFE

Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes

(2011) Pierluigi Tricoci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1

(2011) L. Dowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoprotective protein C pathways and implications for stroke and neurological disorders

(2011) Berislav V. Zlokovic et al.   TRENDS IN NEUROSCIENCES

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways

(2010) A.R. Rezaie   CURRENT MEDICINAL CHEMISTRY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

(2009) S. Danese et al.   BLOOD

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

(2009) L. O. Mosnier et al.   BLOOD

Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

(2009) Vishal Trivedi et al.   CELL

Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function

(2009) Nikita Minhas et al.   FASEB JOURNAL

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology