IL-1 Contributes to the Anti-Cancer Efficacy of Ingenol Mebutate

Ingenol Mebutate Signals via PKC/MEK/ERK in Keratinocytes and Induces Interleukin Decoy Receptors IL1R2 and IL13RA2

(2015) S. N. Freiberger et al.   MOLECULAR CANCER THERAPEUTICS

Caspase-1: an integral regulator of innate immunity

(2015) Stefan Winkler et al.   Seminars in Immunopathology

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Superficial basal cell carcinoma successfully treated with ingenol mebutate gel 0.05%

(2014) Carmen Cantisani et al.   Dermatologic Therapy

The value of nature's natural product library for the discovery of New Chemical Entities: The discovery of ingenol mebutate

(2014) Steven M. Ogbourne et al.   FITOTERAPIA

Localization and Functionality of the Inflammasome in Neutrophils

(2014) Martina Bakele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

CCR2 Deficiency Promotes Exacerbated Chronic Erosive Neutrophil-Dominated Chikungunya Virus Arthritis

(2014) Y. S. Poo et al.   JOURNAL OF VIROLOGY

MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response

(2014) Fabiane Sônego et al.   PLoS One

Neutrophils mediate antibody-induced antitumor effects in mice

(2013) M. Albanesi et al.   BLOOD

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

GATA-2 Transduces LPS-Induced il-1β Gene Expression in Macrophages via a Toll-Like Receptor 4/MD88/MAPK-Dependent Mechanism

(2013) Tsu-Tuan Wu et al.   PLoS One

Neutrophils as effector cells for antibody-based immunotherapy of cancer

(2013) Marjolein van Egmond et al.   SEMINARS IN CANCER BIOLOGY

Long-term Follow-up Study of Ingenol Mebutate Gel for the Treatment of Actinic Keratoses

(2013) Mark Lebwohl et al.   JAMA Dermatology

Effective treatment of squamous cell carcinomas with ingenol mebutate gel in immunologically intact SKH1 mice

(2012) Sarah-Jane Cozzi et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis

(2012) Helder I. Nakaya et al.   ARTHRITIS AND RHEUMATISM

Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma

(2012) Lih-Chyang Chen et al.   EMBO Molecular Medicine

Enhanced FcαRI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells

(2012) Marielle A. Otten et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Critical Role for MyD88-Mediated Neutrophil Recruitment during Clostridium difficile Colitis

(2012) Irene Jarchum et al.   INFECTION AND IMMUNITY

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine

(2012) Michael H. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ingenol Mebutate Gel for Actinic Keratosis

(2012) Mark Lebwohl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

(2011) Sarah-Jane Cozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury

(2010) Yan Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PEP005 (ingenol mebutate) gel for the topical treatment of superficial basal cell carcinoma: Results of a randomized phase IIa trial

(2010) Greg Siller et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

The Skin Cancer Chemotherapeutic Agent Ingenol-3-Angelate (PEP005) Is a Substrate for the Epidermal Multidrug Transporter (ABCB1) and Targets Tumor Vasculature

(2010) Luowei Li et al.   CANCER RESEARCH

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2

(2010) Tomoko Hayashi et al.   MELANOMA RESEARCH

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study

(2009) Greg Siller et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis

(2009) Lawrence Anderson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies

(2009) Thuy T.T. Le et al.   VACCINE

The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-δ dependent manner

(2008) Peter Hampson et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY