Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease

The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once

(2014) Susan E. Tsutakawa et al.   DNA REPAIR

The Arg-62 Residues of the TREX1 Exonuclease Act Across the Dimer Interface Contributing to Catalysis in the Opposing Protomers

(2014) Jason M. Fye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Loss of MEC-17 Leads to Microtubule Instability and Axonal Degeneration

(2014) Brent Neumann et al.   Cell Reports

The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination

(2013) Clinton D. Orebaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation

(2013) S. Pereira-Lopes et al.   JOURNAL OF IMMUNOLOGY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T–product complexes

(2012) Yu-Yuan Hsiao et al.   NUCLEIC ACIDS RESEARCH

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease

(2011) Suzanna L. Bailey et al.   DNA REPAIR

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

(2011) B Namjou et al.   GENES AND IMMUNITY

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome

(2011) Jason M. Fye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity

(2011) Clinton D. Orebaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obscurin Depletion Impairs Organization of Skeletal Muscle in Developing Zebrafish Embryos

(2011) Maide Ö. Raeker et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models

(2011) Simanta Pathak et al.   ARTHRITIS RESEARCH & THERAPY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Mouse Models of Systemic Lupus Erythematosus Reveal a Complex Pathogenesis

(2010) J. B. Rottman et al.   VETERINARY PATHOLOGY

TREX1 gene variant in neuropsychiatric systemic lupus erythematosus

(2009) B. de Vries et al.   ANNALS OF THE RHEUMATIC DISEASES

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease: Figure 1

(2009) Tomas Lindahl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY