Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

A novel pathogenetic concept—antiviral immunity in lupus nephritis

(2012) Adriana Migliorini et al.   Nature Reviews Nephrology

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

(2011) Huihui Chen et al.   CELL

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Cytoplasmic DNA innate immune pathways

(2011) Glen N. Barber   IMMUNOLOGICAL REVIEWS

The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity

(2011) Clinton D. Orebaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cellular pathology of lysosomal diseases

(2011) Timothy M Cox et al.   JOURNAL OF PATHOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

(2011) Miguel A Mata et al.   Nature Chemical Biology

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Immune responses to influenza virus infection

(2011) J.H.C.M. Kreijtz et al.   VIRUS RESEARCH

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

(2010) Georgia Ramantani et al.   ARTHRITIS AND RHEUMATISM

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL