Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Targeting Histone Lysine Demethylases by Truncating the Histone 3 Tail to Obtain Selective Substrate-Based Inhibitors

(2011) Brian Lohse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

(2011) J. He et al.   BLOOD

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

(2011) Kai-Hsuan Chang et al.   ChemMedChem

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

(2011) Xuelai Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of homogeneous luminescence assays for histone demethylase catalysis and binding

(2010) Akane Kawamura et al.   ANALYTICAL BIOCHEMISTRY

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

(2010) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors

(2010) Shohei Hamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)

(2009) Rok Sekirnik et al.   CHEMICAL COMMUNICATIONS

A New Ligation Strategy for Peptide and Protein Glycosylation: Photoinduced Thiol-Ene Coupling

(2009) Alessandro Dondoni et al.   CHEMISTRY-A EUROPEAN JOURNAL

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase

(2009) Christoph Loenarz et al.   HUMAN MOLECULAR GENETICS

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

(2009) John R Horton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Combinatorial Mass Spectrometry Leads to Metallo-β-lactamase Inhibitors

(2008) Benoît M. R. Liénard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥

(2008) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY