Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Discovery of Substrates for a SET Domain Lysine Methyltransferase Predicted by Multistate Computational Protein Design

(2015) Sylvain Lanouette et al.   STRUCTURE

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

(2015) Ramzi F. Sweis et al.   ACS Medicinal Chemistry Letters

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

(2015) Makoto Nakakido et al.   NEOPLASIA

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.

(2015) Rocky Cipriano et al.   Oncotarget

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

(2015) Hyun-Soo Cho et al.   NEOPLASIA

Overexpression of SMYD2 contributes to malignant outcome in gastric cancer

(2014) S Komatsu et al.   BRITISH JOURNAL OF CANCER

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

(2014) Ryuji Hamamoto et al.   CANCER LETTERS

AHNAK: The giant jack of all trades

(2014) T.A. Davis et al.   CELLULAR SIGNALLING

A Chemical Proteomics Approach for Global Analysis of Lysine Monomethylome Profiling

(2014) Zhixiang Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway

(2014) I H Lee et al.   ONCOGENE

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

(2014) D. Barsyte-Lovejoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells

(2014) Lianhua Piao et al.   NEOPLASIA

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

(2013) Kyle D. Konze et al.   ACS Chemical Biology

Large-scale global identification of protein lysine methylation in vivo

(2013) Xing-Jun Cao et al.   Epigenetics

Immunoaffinity Enrichment and Mass Spectrometry Analysis of Protein Methylation

(2013) Ailan Guo et al.   MOLECULAR & CELLULAR PROTEOMICS

A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation

(2013) Kaitlyn E. Moore et al.   MOLECULAR CELL

A Method for Systematic Mapping of Protein Lysine Methylation Identifies Functions for HP1β in DNA Damage Response

(2013) Huadong Liu et al.   MOLECULAR CELL

Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B

(2013) R Cipriano et al.   ONCOGENE

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

FAM83B mediates EGFR- and RAS-driven oncogenic transformation

(2012) Rocky Cipriano et al.   JOURNAL OF CLINICAL INVESTIGATION

NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum

(2012) Ying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SILAC-based quantitative proteomic analysis of gastric cancer secretome

(2012) Arivusudar Marimuthu et al.   Proteomics Clinical Applications

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Specificity Analysis-Based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase

(2011) Arunkumar Dhayalan et al.   CHEMISTRY & BIOLOGY

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

(2011) Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

(2011) Masoud Vedadi et al.   Nature Chemical Biology

Structural Basis of Substrate Methylation and Inhibition of SMYD2

(2011) Andrew D. Ferguson et al.   STRUCTURE

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

(2011) Mohamed Abu-Farha et al.   Journal of Molecular Cell Biology

Methylation of the Retinoblastoma Tumor Suppressor by SMYD2

(2010) Louis A. Saddic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

(2009) Shuhei Komatsu et al.   CARCINOGENESIS

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

The emerging field of dynamic lysine methylation of non-histone proteins

(2008) Jing Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Ahnak Protein Activates Protein Kinase C (PKC) through Dissociation of the PKC-Protein Phosphatase 2A Complex

(2008) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predicting Protein Post-translational Modifications Using Meta-analysis of Proteome Scale Data Sets

(2008) Daniel Schwartz et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein lysine methyltransferase G9a acts on non-histone targets

(2008) Philipp Rathert et al.   Nature Chemical Biology

The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry

(2008) Judit Villén et al.   Nature Protocols