EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
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Title
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
Authors
Keywords
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Journal
NATURE
Volume 492, Issue 7427, Pages 108-112
Publisher
Springer Nature
Online
2012-10-10
DOI
10.1038/nature11606
References
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Related references
Note: Only part of the references are listed.- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
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- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
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- Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
- (2011) Masashi Takawa et al. CANCER SCIENCE
- The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
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- (2011) Russell J. H. Ryan et al. PLoS One
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
- (2010) Nina Wagener et al. BMC CANCER
- Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
- (2010) H Makishima et al. LEUKEMIA
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
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- Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
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- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
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- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
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- Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
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