ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
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Title
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
Authors
Keywords
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Journal
Nature Communications
Volume 7, Issue -, Pages 13837
Publisher
Springer Nature
Online
2016-12-13
DOI
10.1038/ncomms13837
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Note: Only part of the references are listed.- A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors
- (2016) Sergio Ruiz et al. MOLECULAR CELL
- Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
- (2016) James Campbell et al. Cell Reports
- ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells
- (2015) M. Kwok et al. BLOOD
- Molecular Pathways: Targeting ATR in Cancer Therapy
- (2015) L. M. Karnitz et al. CLINICAL CANCER RESEARCH
- The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis
- (2015) Peter M. Brownlee et al. DNA REPAIR
- Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway
- (2015) Marwan Kwok et al. LANCET
- Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
- (2015) R. L. Flynn et al. SCIENCE
- ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
- (2015) J. Shen et al. Cancer Discovery
- ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
- (2014) R. Josse et al. CANCER RESEARCH
- SWI/SNF Factors Required for Cellular Resistance to DNA Damage Include ARID1A and ARID1B and Show Interdependent Protein Stability
- (2014) R. Watanabe et al. CANCER RESEARCH
- ATR Pathway Inhibition Is Synthetically Lethal in Cancer Cells with ERCC1 Deficiency
- (2014) K. N. Mohni et al. CANCER RESEARCH
- Roles of chromatin remodellers in DNA double strand break repair
- (2014) Penny A. Jeggo et al. EXPERIMENTAL CELL RESEARCH
- Chemical strategies for development of ATR inhibitors
- (2014) Sabin Llona-Minguez et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Topoisomerase IIα in chromosome instability and personalized cancer therapy
- (2014) T Chen et al. ONCOGENE
- A rationale to target the SWI/SNF complex for cancer therapy
- (2014) Anja F. Hohmann et al. TRENDS IN GENETICS
- ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
- (2013) C. J. Huntoon et al. CANCER RESEARCH
- Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity
- (2013) Kevin M. Foote et al. JOURNAL OF MEDICINAL CHEMISTRY
- BAF complexes facilitate decatenation of DNA by topoisomerase IIα
- (2013) Emily C. Dykhuizen et al. NATURE
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- The ATM protein kinase: regulating the cellular response to genotoxic stress and more
- (2013) Yosef Shiloh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nucleosome sliding mechanisms: new twists in a looped history
- (2013) Felix Mueller-Planitz et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase Inhibition Is Synthetically Lethal in XRCC1 Deficient Ovarian Cancer Cells
- (2013) Rebeka Sultana et al. PLoS One
- Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
- (2012) I M Pires et al. BRITISH JOURNAL OF CANCER
- Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase
- (2011) Edward A. Nam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation
- (2011) Shizhou Liu et al. MOLECULAR CELL
- Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
- (2011) Philip M Reaper et al. Nature Chemical Biology
- A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
- (2011) Luis I Toledo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ATR mediates cisplatin resistance in a p53 genotype-specific manner
- (2011) N Sangster-Guity et al. ONCOGENE
- Functional Viability Profiles of Breast Cancer
- (2011) R. Brough et al. Cancer Discovery
- DNA Copy Numbers Profiles in Affinity-Purified Ovarian Clear Cell Carcinoma
- (2010) K. T. Kuo et al. CLINICAL CANCER RESEARCH
- Rad9A Is Required for G2Decatenation Checkpoint and to Prevent Endoreduplication in Response to Topoisomerase II Inhibition
- (2010) Deborah A. Greer Card et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
- (2010) Mary Ellen Moynahan et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells
- (2009) M. Johnson et al. NUCLEIC ACIDS RESEARCH
- A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity
- (2008) Christopher J. Lord et al. DNA REPAIR
- ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
- (2008) X. Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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