The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
Authors
Keywords
Protein arginine methyltransferase, Histones, Spliceosome, Development, Cancer
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 72, Issue 11, Pages 2041-2059
Publisher
Springer Nature
Online
2015-02-06
DOI
10.1007/s00018-015-1847-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Readers of histone methylarginine marks
- (2014) Sitaram Gayatri et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma
- (2014) Fengting Yan et al. CANCER RESEARCH
- Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis
- (2014) Tong-You Wade Wei et al. CELLULAR SIGNALLING
- Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition
- (2014) Reem Ibrahim et al. HUMAN PATHOLOGY
- Tumor Necrosis Factor (TNF)-α Induction of CXCL10 in Endothelial Cells Requires Protein Arginine Methyltransferase 5 (PRMT5)-mediated Nuclear Factor (NF)-κB p65 Methylation
- (2014) Daniel P. Harris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Remodeled Protein Arginine Methyltransferase 1 (PRMT1) Generates Symmetric Dimethylarginine
- (2014) Shanying Gui et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability
- (2014) Marta M. Fay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Cardiomyocyte Hypertrophy by Protein Arginine Methyltransferase 5
- (2014) Ming Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro
- (2014) Xiaosi Han et al. JOURNAL OF NEURO-ONCOLOGY
- A draft map of the human proteome
- (2014) Min-Sik Kim et al. NATURE
- Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei
- (2014) Chongyuan Wang et al. PLoS One
- PRMT5 is Required for Human Embryonic Stem Cell Proliferation But Not Pluripotency
- (2014) Sofia Gkountela et al. Stem Cell Reviews and Reports
- Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin
- (2014) Anatoly Uzdensky et al. TUMOR BIOLOGY
- Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development
- (2014) Wei-Lin Wang et al. Epigenetics & Chromatin
- Substrate Specificity, Processivity, and Kinetic Mechanism of Protein Arginine Methyltransferase 5
- (2013) Min Wang et al. BIOCHEMISTRY
- Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome
- (2013) B. Gurung et al. CANCER RESEARCH
- Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors
- (2013) Konstantin Shilo et al. Diagnostic Pathology
- Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel
- (2013) Pedro Beltran-Alvarez et al. FEBS LETTERS
- Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery
- (2013) M. Bezzi et al. GENES & DEVELOPMENT
- Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions
- (2013) You Feng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes
- (2013) Taiki Tsutsui et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer
- (2013) Xiangxiang Bao et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Menin Directly Represses Gli1 Expression Independent of Canonical Hedgehog Signaling
- (2013) Buddha Gurung et al. MOLECULAR CANCER RESEARCH
- Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1
- (2013) Shunsheng Zheng et al. MOLECULAR CELL
- Structural Basis of Assembly Chaperone- Mediated snRNP Formation
- (2013) Clemens Grimm et al. MOLECULAR CELL
- PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome
- (2013) Michael Girardot et al. NUCLEIC ACIDS RESEARCH
- The UCSC Genome Browser database: 2014 update
- (2013) Donna Karolchik et al. NUCLEIC ACIDS RESEARCH
- Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity
- (2013) Meng-Chiao Ho et al. PLoS One
- Functional Domains of Androgen Receptor Coactivator p44/Mep50/WDR77and Its Interaction with Smad1
- (2013) Yirong Li et al. PLoS One
- cGMP-Dependent Protein Kinase Iβ Interacts with p44/WDR77 to Regulate Androgen Receptor-Driven Gene Expression
- (2013) Liran Zhou et al. PLoS One
- PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27Kip1
- (2013) Courtney Nicholas et al. PLoS One
- Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer
- (2013) Balázs Győrffy et al. PLoS One
- Histone H4R3 Methylation Catalyzed by SKB1/PRMT5 Is Required for Maintaining Shoot Apical Meristem
- (2013) Minghui Yue et al. PLoS One
- PRMT5 modulates the metabolic response to fasting signals
- (2013) W.-W. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PRMT5 dimethylates R30 of the p65 subunit to activate NF- B
- (2013) H. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Menin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors
- (2013) Buddha Gurung et al. Epigenomics
- Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs
- (2013) Surbhi Dhar et al. Scientific Reports
- Modulation of Epstein–Barr Virus Nuclear Antigen 2-dependent transcription by protein arginine methyltransferase 5
- (2012) Cheng-Der Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Protein arginine methyltransferase 5 is essential for growth of lung cancer cells
- (2012) Zhongping Gu et al. BIOCHEMICAL JOURNAL
- A histone arginine methylation localizes to nucleosomes in satellite II and III DNA sequences in the human genome
- (2012) Daniel Capurso et al. BMC GENOMICS
- Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade
- (2012) Tong-You W. Wei et al. CANCER SCIENCE
- Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4
- (2012) S. S. Dhar et al. GENES & DEVELOPMENT
- A Novel Histone H4 Arginine 3 Methylation-sensitive Histone H4 Binding Activity and Transcriptional Regulatory Function for Signal Recognition Particle Subunits SRP68 and SRP72
- (2012) Jingjing Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues
- (2012) Cecilia I. Zurita-Lopez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transcription Factor Positive Regulatory Domain 4 (PRDM4) Recruits Protein Arginine Methyltransferase 5 (PRMT5) to Mediate Histone Arginine Methylation and Control Neural Stem Cell Proliferation and Differentiation
- (2012) Alexandra Chittka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target
- (2012) Yan Jia et al. MEDICINAL RESEARCH REVIEWS
- Loss of the Androgen Receptor Cofactor p44/WDR77 Induces Astrogliosis
- (2012) B. Vincent et al. MOLECULAR AND CELLULAR BIOLOGY
- Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance
- (2012) Valentina Migliori et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Subcellular Localization of p44/WDR77 Determines Proliferation and Differentiation of Prostate Epithelial Cells
- (2012) Shen Gao et al. PLoS One
- Crystal structure of the human PRMT5:MEP50 complex
- (2012) S. Antonysamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses
- (2012) Rami Doueiri et al. Retrovirology
- An Allosteric Inhibitor of Protein Arginine Methyltransferase 3
- (2012) Alena Siarheyeva et al. STRUCTURE
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Histone H3R2 Symmetric Dimethylation and Histone H3K4 Trimethylation Are Tightly Correlated in Eukaryotic Genomes
- (2012) Chih-Chi Yuan et al. Cell Reports
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
- (2011) Fan Liu et al. CANCER CELL
- Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4
- (2011) M. A. Powers et al. CANCER RESEARCH
- The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation
- (2011) C Paul et al. CELL DEATH AND DIFFERENTIATION
- Protein Arginine Methylation in Parasitic Protozoa
- (2011) John C. Fisk et al. EUKARYOTIC CELL
- Protein Arginine Methyltransferase Prmt5-Mep50 Methylates Histones H2A and H4 and the Histone Chaperone Nucleoplasmin inXenopus laevisEggs
- (2011) Carola Wilczek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein Arginine Methyltransferase 5 (PRMT5) Signaling Suppresses Protein Kinase Cδ- and p38δ-dependent Signaling and Keratinocyte Differentiation
- (2011) Santosh R. Kanade et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone H4 Acetylation Differentially Modulates Arginine Methylation by an inCisMechanism
- (2011) You Feng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of the Plant Epigenetic Protein Arginine Methyltransferase 10
- (2011) Yuan Cheng et al. JOURNAL OF MOLECULAR BIOLOGY
- Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation
- (2011) Jung-Mao Hsu et al. NATURE CELL BIOLOGY
- Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes
- (2011) Sookil Tae et al. NUCLEIC ACIDS RESEARCH
- Nuclear Transport Signals Control Cellular Localization and Function of Androgen Receptor Cofactor p44/WDR77
- (2011) Zhongping Gu et al. PLoS One
- Expression and Function of Androgen Receptor Coactivator p44/Mep50/WDR77 in Ovarian Cancer
- (2011) Martin Ligr et al. PLoS One
- The Methyltransferases PRMT4/CARM1 and PRMT5 Control Differentially Myogenesis in Zebrafish
- (2011) Julie Batut et al. PLoS One
- Structural insights into protein arginine symmetric dimethylation by PRMT5
- (2011) L. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Versatility of PRMT5-induced methylation in growth control and development
- (2011) Vrajesh Karkhanis et al. TRENDS IN BIOCHEMICAL SCIENCES
- Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression
- (2010) G. Rank et al. BLOOD
- Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase
- (2010) Priya Aggarwal et al. CANCER CELL
- Altered Differentiation and Proliferation of Prostate Epithelium in Mice Lacking the Androgen Receptor Cofactor p44/WDR77
- (2010) Shen Gao et al. ENDOCRINOLOGY
- Histone arginine methylation
- (2010) Alessandra Di Lorenzo et al. FEBS LETTERS
- How does the Royal Family of Tudor rule the PIWI-interacting RNA pathway?
- (2010) M. C. Siomi et al. GENES & DEVELOPMENT
- Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency
- (2010) W.-W. Tee et al. GENES & DEVELOPMENT
- Arginine Methylation of Vasa Protein Is Conserved across Phyla
- (2010) Yohei Kirino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Methylation of Ribosomal Protein S10 by Protein-arginine Methyltransferase 5 Regulates Ribosome Biogenesis
- (2010) Jinqi Ren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity
- (2010) Gernot Guderian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
- (2010) Zhigang Guo et al. Nature Chemical Biology
- The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4
- (2010) C. Mallappa et al. NUCLEIC ACIDS RESEARCH
- Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain
- (2010) K. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines
- (2009) Kazumichi M Nishida et al. EMBO JOURNAL
- Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain
- (2009) Junji Otani et al. EMBO REPORTS
- Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
- (2009) V. V. Vagin et al. GENES & DEVELOPMENT
- Role of pICLn in Methylation of Sm Proteins by PRMT5
- (2009) G. Scott Pesiridis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion
- (2009) Yi Peng et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Distinct Protein Arginine Methyltransferases Promote ATP-Dependent Chromatin Remodeling Function at Different Stages of Skeletal Muscle Differentiation
- (2009) C. S. Dacwag et al. MOLECULAR AND CELLULAR BIOLOGY
- Protein Arginine Methylation in Mammals: Who, What, and Why
- (2009) Mark T. Bedford et al. MOLECULAR CELL
- Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability
- (2009) Yohei Kirino et al. NATURE CELL BIOLOGY
- Protein methyltransferases as a target class for drug discovery
- (2009) Robert A. Copeland et al. NATURE REVIEWS DRUG DISCOVERY
- Loss of the Mili-interacting Tudor domain–containing protein-1 activates transposons and alters the Mili-associated small RNA profile
- (2009) Michael Reuter et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
- (2009) Quan Zhao et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- PRMT5 is required for cell-cycle progression and p53 tumor suppressor function
- (2009) A. Scoumanne et al. NUCLEIC ACIDS RESEARCH
- Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization
- (2009) Y. Kirino et al. RNA
- Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors
- (2008) Dawid Eckert et al. BMC DEVELOPMENTAL BIOLOGY
- An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs
- (2008) Ashwin Chari et al. CELL
- The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
- (2008) Matthieu Lacroix et al. EMBO REPORTS
- Deciphering the assembly pathway of Sm-class U snRNPs
- (2008) Nils Neuenkirchen et al. FEBS LETTERS
- Analysis of Histones inXenopus laevis
- (2008) Joshua J. Nicklay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analysis of Histones inXenopus laevis
- (2008) David Shechter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells
- (2008) L. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 To Mediate SNAIL-Dependent Transcriptional Repression
- (2008) Z. Hou et al. MOLECULAR AND CELLULAR BIOLOGY
- Arginine methylation regulates the p53 response
- (2008) Martin Jansson et al. NATURE CELL BIOLOGY
- Reprogramming Primordial Germ Cells into Pluripotent Stem Cells
- (2008) Gabriela Durcova-Hills et al. PLoS One
- Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer
- (2008) Yi Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More