标题
Marked for death: targeting epigenetic changes in cancer
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 4, Pages 241-263
出版商
Springer Nature
发表日期
2017-03-10
DOI
10.1038/nrd.2016.256
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
- (2016) Anna C. Groner et al. CANCER CELL
- Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development
- (2016) Rui Lu et al. CANCER CELL
- G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status
- (2016) Pallavi Agarwal et al. CANCER LETTERS
- A Landscape of Pharmacogenomic Interactions in Cancer
- (2016) Francesco Iorio et al. CELL
- Dual Chromatin and Cytoskeletal Remodeling by SETD2
- (2016) In Young Park et al. CELL
- HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma
- (2016) Hong Zheng et al. CLINICAL CANCER RESEARCH
- High rate of complete responses to immune checkpoint inhibitors in patients with relapsed or refractory Hodgkin lymphoma previously exposed to epigenetic therapy
- (2016) Lorenzo Falchi et al. Journal of Hematology & Oncology
- MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses
- (2016) Andre Kunert et al. JOURNAL OF IMMUNOLOGY
- Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
- (2016) Erik Eggert et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates
- (2016) Hazem Ahmed et al. JOURNAL OF PROTEOME RESEARCH
- Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics
- (2016) Jonathan B. Olsen et al. MOLECULAR & CELLULAR PROTEOMICS
- Synthetic Lethal Targeting of ARID1A -Mutant Ovarian Clear Cell Tumors with Dasatinib
- (2016) Rowan E. Miller et al. MOLECULAR CANCER THERAPEUTICS
- Bet on drug resistance
- (2016) Jeff Settleman NATURE
- Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
- (2016) Marco Sciacovelli et al. NATURE
- Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
- (2016) Shaokun Shu et al. NATURE
- An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
- (2016) Maia Vinogradova et al. Nature Chemical Biology
- Targeting EZH2 in cancer
- (2016) Kimberly H Kim et al. NATURE MEDICINE
- Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
- (2016) Konstantinos J. Mavrakis et al. SCIENCE
- MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
- (2016) Gregory V. Kryukov et al. SCIENCE
- The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
- (2016) D. Fang et al. SCIENCE
- Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation
- (2016) Yujing Xiong et al. Stem Cell Reviews and Reports
- The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
- (2016) Mélissa Carbonneau et al. Nature Communications
- The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
- (2016) Bernard Pereira et al. Nature Communications
- ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
- (2016) Chris T. Williamson et al. Nature Communications
- Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis
- (2016) C. Kadoch Cancer Discovery
- BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
- (2016) Hengrui Zhu et al. Cell Reports
- MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
- (2016) Katya Marjon et al. Cell Reports
- Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation
- (2016) Yujing Xiong et al. Stem Cell Reviews and Reports
- Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer
- (2016) Yuanhui Jia et al. Cell Discovery
- Aging and DNA methylation
- (2015) Marc Jung et al. BMC BIOLOGY
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
- (2015) Helai P. Mohammad et al. CANCER CELL
- Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation
- (2015) Sophia X. Pfister et al. CANCER CELL
- PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
- (2015) Nisha Nagarsheth et al. CANCER RESEARCH
- The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
- (2015) Bhavatarini Vangamudi et al. CANCER RESEARCH
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- (2015) Katherine B. Chiappinelli et al. CELL
- The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
- (2015) Nicole Stopa et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma
- (2015) H.-Z. Lee et al. CLINICAL CANCER RESEARCH
- Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy
- (2015) M. C. Caino et al. CLINICAL CANCER RESEARCH
- Histo-genomic stratification reveals the frequent amplification/overexpression ofCCNE1andBRD4genes in non-BRCAness high grade ovarian carcinoma
- (2015) Oumou Goundiam et al. INTERNATIONAL JOURNAL OF CANCER
- BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma
- (2015) Pengfei Zhang et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2
- (2015) Hannah Nguyen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents
- (2015) Madhusoodanan Mottamal et al. MOLECULES
- Non-coding recurrent mutations in chronic lymphocytic leukaemia
- (2015) Xose S. Puente et al. NATURE
- Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
- (2015) Dongjun Peng et al. NATURE
- Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
- (2015) Philipp Rathert et al. NATURE
- BET inhibitor resistance emerges from leukaemia stem cells
- (2015) Chun Yew Fong et al. NATURE
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- What are super-enhancers?
- (2015) Sebastian Pott et al. NATURE GENETICS
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
- (2015) Kimberly H Kim et al. NATURE MEDICINE
- SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets
- (2015) Jing Guo et al. NUCLEIC ACIDS RESEARCH
- Gene essentiality and synthetic lethality in haploid human cells
- (2015) V. A. Blomen et al. SCIENCE
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- The NSD family of protein methyltransferases in human cancer
- (2015) Theodore Vougiouklakis et al. Epigenomics
- Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
- (2015) Akihiro Fujimoto et al. Nature Communications
- Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression
- (2015) H. Ogiwara et al. Cancer Discovery
- ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
- (2015) J. Shen et al. Cancer Discovery
- JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells
- (2015) Bo Tang et al. Oncotarget
- RE-IIBP Methylates H3K79 and Induces MEIS1-mediated Apoptosis via H2BK120 Ubiquitination by RNF20
- (2015) Jin Woo Park et al. Scientific Reports
- TET proteins and the control of cytosine demethylation in cancer
- (2015) Laurianne Scourzic et al. Genome Medicine
- HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
- (2015) D. M. Woods et al. Cancer Immunology Research
- Synthesis of lysine methyltransferase inhibitors
- (2015) Chunngai Hui et al. Frontiers in Chemistry
- The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia
- (2015) William N. Pappano et al. PLoS One
- Alterations of immune response of non-small cell lung cancer with Azacytidine
- (2015) John Wrangle et al. Oncotarget
- Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition
- (2015) Eleftherios P. Samartzis et al. Oncotarget
- Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS
- (2014) V. Proulle et al. BLOOD
- The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
- (2014) Joni Van der Meulen et al. BLOOD
- Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
- (2014) B. Xu et al. BLOOD
- Vulnerabilities of Mutant SWI/SNF Complexes in Cancer
- (2014) Katherine C. Helming et al. CANCER CELL
- Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
- (2014) D. Mittal et al. CANCER RESEARCH
- Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα
- (2014) Keisuke Yamamoto et al. CARCINOGENESIS
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
- (2014) Luke A. Gilbert et al. CELL
- 5LBA Results of a first-in-man phase I trial assessing OTX015, an orally available BET-bromodomain (BRD) inhibitor, in advanced hematologic malignancies
- (2014) A. Stathis et al. EUROPEAN JOURNAL OF CANCER
- KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review
- (2014) Young-Won Chin et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor
- (2014) Chia-Han Chu et al. JOURNAL OF MEDICINAL CHEMISTRY
- High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction
- (2014) Shihan He et al. JOURNAL OF MEDICINAL CHEMISTRY
- Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts
- (2014) Pragya Srivastava et al. LEUKEMIA RESEARCH
- Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
- (2014) B. G. Wilson et al. MOLECULAR AND CELLULAR BIOLOGY
- EZH2: Not EZHY (Easy) to Deal
- (2014) Gauri Deb et al. MOLECULAR CANCER RESEARCH
- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
- (2014) Fang Cao et al. MOLECULAR CELL
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- A vaccine targeting mutant IDH1 induces antitumour immunity
- (2014) Theresa Schumacher et al. NATURE
- Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
- (2014) Carolyn S Lee et al. NATURE GENETICS
- Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
- (2014) Marco Gerlinger et al. NATURE GENETICS
- ARID1B is a specific vulnerability in ARID1A-mutant cancers
- (2014) Katherine C Helming et al. NATURE MEDICINE
- Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
- (2014) Rintaro Hashizume et al. NATURE MEDICINE
- SET-ting the stage for DNA repair
- (2014) Deepak K Jha et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
- (2014) François Aymard et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy
- (2014) Wei Liu et al. PLoS One
- Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
- (2014) K. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
- (2014) G. R. Hoffman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A rationale to target the SWI/SNF complex for cancer therapy
- (2014) Anja F. Hohmann et al. TRENDS IN GENETICS
- Histone H3 Mutations in Pediatric Brain Tumors
- (2014) X. Liu et al. Cold Spring Harbor Perspectives in Biology
- Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
- (2014) Ramzi F. Sweis et al. ACS Medicinal Chemistry Letters
- Architects of the genome: CHD dysfunction in cancer, developmental disorders and neurological syndromes
- (2014) Wangzhi Li et al. Epigenomics
- A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice
- (2014) Chen-Chun Pai et al. Nature Communications
- SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
- (2014) Sophia X. Pfister et al. Cell Reports
- SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
- (2014) Sílvia Carvalho et al. eLife
- Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer
- (2014) K. Odunsi et al. Cancer Immunology Research
- The anticancer effects of HDAC inhibitors require the immune system
- (2014) Alison C West et al. OncoImmunology
- Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
- (2013) Adam M. Fontebasso et al. ACTA NEUROPATHOLOGICA
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Histone H3.3 Mutations: A Variant Path to Cancer
- (2013) Benjamin T.K. Yuen et al. CANCER CELL
- Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
- (2013) Sebastian Bender et al. CANCER CELL
- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells
- (2013) W. L. Berry et al. CANCER RESEARCH
- A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
- (2013) T. Oike et al. CANCER RESEARCH
- KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors
- (2013) Joshua C. Black et al. CELL
- Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2: A Report by MSKCC and the KIRC TCGA Research Network
- (2013) A. A. Hakimi et al. CLINICAL CANCER RESEARCH
- Effects of treatment with histone deacetylase inhibitors in solid tumors: a review based on 30 clinical trials
- (2013) Tianzhu Qiu et al. Future Oncology
- The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
- (2013) K.-M. Chan et al. GENES & DEVELOPMENT
- Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
- (2013) Feng Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents
- (2013) H Yang et al. LEUKEMIA
- Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions
- (2013) Lisa M. Kopp et al. MOLECULAR IMMUNOLOGY
- Landscape of genomic alterations in cervical carcinomas
- (2013) Akinyemi I. Ojesina et al. NATURE
- Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer
- (2013) Woojin Kim et al. Nature Chemical Biology
- Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas
- (2013) Miriam J Smith et al. NATURE GENETICS
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
- (2013) Kelly Coffey et al. NUCLEIC ACIDS RESEARCH
- MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma
- (2013) A R Grayson et al. ONCOGENE
- The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers
- (2013) A. Hunter Shain et al. PLoS One
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1
- (2013) O. A. Romero et al. Cancer Discovery
- Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
- (2013) Lynn Bjerke et al. Cancer Discovery
- Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
- (2013) Alexandre Puissant et al. Cancer Discovery
- Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
- (2013) Sergiy Konovalov et al. Journal of Ovarian Research
- The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma
- (2013) Kristian W Pajtler et al. Acta Neuropathologica Communications
- Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
- (2012) Esther C. Y. Woon et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mutational analysis ofDNMT3Agene in acute leukemias and common solid cancers
- (2012) Min S. Kim et al. APMIS
- Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing
- (2012) A. Dolnik et al. BLOOD
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
- (2012) Marcin Imielinski et al. CELL
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Recurrent inactivating mutations ofARID2in non-small cell lung carcinoma
- (2012) Gilles Manceau et al. INTERNATIONAL JOURNAL OF CANCER
- Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
- (2012) L Chen et al. LEUKEMIA
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Novel mutations target distinct subgroups of medulloblastoma
- (2012) Giles Robinson et al. NATURE
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- New lysine methyltransferase drug targets in cancer
- (2012) Tobias Wagner et al. NATURE BIOTECHNOLOGY
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
- (2012) Matthieu Le Gallo et al. NATURE GENETICS
- The genetic landscape of mutations in Burkitt lymphoma
- (2012) Cassandra Love et al. NATURE GENETICS
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
- (2012) Mark Sausen et al. NATURE GENETICS
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Epigenetic protein families: a new frontier for drug discovery
- (2012) Cheryl H. Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- TET2andDNMT3AMutations in Human T-Cell Lymphoma
- (2012) Lucile Couronné et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
- (2012) Li Shen et al. PLoS One
- Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer
- (2012) Tangfeng Lv et al. PLoS One
- Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer
- (2012) A. H. Shain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients
- (2012) Ze-Kun Zhao WORLD JOURNAL OF GASTROENTEROLOGY
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- SDH mutations in cancer
- (2011) Chiara Bardella et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- Inhibition of Histone Lysine Methylation Enhances Cancer-Testis Antigen Expression in Lung Cancer Cells: Implications for Adoptive Immunotherapy of Cancer
- (2011) M. Rao et al. CANCER RESEARCH
- Genetic Interactions in Cancer Progression and Treatment
- (2011) Alan Ashworth et al. CELL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- Romidepsin: a novel histone deacetylase inhibitor for cancer
- (2011) Erin M Bertino et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
- (2011) M Fernanda Amary et al. JOURNAL OF PATHOLOGY
- Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway
- (2011) Veerauo V Konkankit et al. Journal of Translational Medicine
- Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
- (2011) M J Walter et al. LEUKEMIA
- CREBBP mutations in relapsed acute lymphoblastic leukaemia
- (2011) Charles G. Mullighan et al. NATURE
- Inactivating mutations of acetyltransferase genes in B-cell lymphoma
- (2011) Laura Pasqualucci et al. NATURE
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
- (2011) Ignacio Varela et al. NATURE
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- The genomic complexity of primary human prostate cancer
- (2011) Michael F. Berger et al. NATURE
- Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
- (2011) Yaoting Gui et al. NATURE GENETICS
- Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
- (2011) Kai Wang et al. NATURE GENETICS
- Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
- (2011) Meng Li et al. NATURE GENETICS
- Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
- (2011) Xiao-Jing Yan et al. NATURE GENETICS
- Harnessing synthetic lethal interactions in anticancer drug discovery
- (2011) Denise A. Chan et al. NATURE REVIEWS DRUG DISCOVERY
- The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma
- (2011) J A Anderton et al. ONCOGENE
- Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
- (2011) L. Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
- (2011) Y. Jiao et al. SCIENCE
- Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer
- (2011) R. A. Juergens et al. Cancer Discovery
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- research paper: Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia
- (2010) Daniel Antunes Moreno et al. BRITISH JOURNAL OF HAEMATOLOGY
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
- (2010) Austin T. Thiel et al. CANCER CELL
- Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
- (2010) Boris G. Wilson et al. CANCER CELL
- Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
- (2010) Gerben Duns et al. CANCER RESEARCH
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
- (2010) Sreenath V. Sharma et al. CELL
- HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth
- (2010) T. Milde et al. CLINICAL CANCER RESEARCH
- Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
- (2010) David C. Bedford et al. Epigenetics
- Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas
- (2010) Jefferson Pessoa Hemerly et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma
- (2010) Heiner Adams et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- PHF6 mutations in adult acute myeloid leukemia
- (2010) P Van Vlierberghe et al. LEUKEMIA
- Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
- (2010) O Kosmider et al. LEUKEMIA
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- (2010) Gillian L. Dalgliesh et al. NATURE
- TRIM24 links a non-canonical histone signature to breast cancer
- (2010) Wen-Wei Tsai et al. NATURE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas
- (2010) Kimberly C. Wiegand et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer-associated IDH mutations: biomarker and therapeutic opportunities
- (2010) K E Yen et al. ONCOGENE
- Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining
- (2010) S. Fnu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
- (2010) Siân Jones et al. SCIENCE
- Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
- (2009) Shohei Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
- (2009) O. Abdel-Wahab et al. BLOOD
- The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters
- (2009) W Al Sarakbi et al. BMC CANCER
- Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex
- (2009) X. Wang et al. CANCER RESEARCH
- Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma
- (2009) Shuhei Komatsu et al. CARCINOGENESIS
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- Acquired mutations in TET2 are common in myelodysplastic syndromes
- (2009) Saskia M C Langemeijer et al. NATURE GENETICS
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA hypomethylation in cancer cells
- (2009) Melanie Ehrlich Epigenomics
- Analysis of the IDH1 codon 132 mutation in brain tumors
- (2008) Jörg Balss et al. ACTA NEUROPATHOLOGICA
- Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
- (2008) Florian R Fritzsche et al. BMC CANCER
- Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors
- (2008) Markus Heidenblad et al. BMC Medical Genomics
- Histone Deacetylase 8 in Neuroblastoma Tumorigenesis
- (2008) I. Oehme et al. CLINICAL CANCER RESEARCH
- An Inactivating Mutation in HDAC2 Leads to Dysregulation of Apoptosis Mediated by APAF1
- (2008) Christin L. Hanigan et al. GASTROENTEROLOGY
- Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor
- (2008) P.V. Peña et al. JOURNAL OF MOLECULAR BIOLOGY
- Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
- (2008) Portia A Kreiger et al. MODERN PATHOLOGY
- SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus
- (2008) S. K. Kia et al. MOLECULAR AND CELLULAR BIOLOGY
- Small cell undifferentiated variant of hepatoblastoma: Adverse clinical and molecular features similar to rhabdoid tumors
- (2008) Angela D. Trobaugh-Lotrario et al. PEDIATRIC BLOOD & CANCER
- Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast
- (2008) A. Roguev et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started