LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

(2015) Hyun-Soo Cho et al.   NEOPLASIA

Cancer epigenetics drug discovery and development: the challenge of hitting the mark

(2014) Robert M. Campbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Insights into Estrogen Receptor α Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation

(2014) Yuanyuan Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY

SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor

(2014) Luis Henrique Toshihiro Sakamoto et al.   LEUKEMIA RESEARCH

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly(ADP-ribosyl)ation Activity in Cancer Cells

(2014) Lianhua Piao et al.   NEOPLASIA

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

(2013) V. Proserpio et al.   GENES & DEVELOPMENT

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Regulation of estrogen receptor   by histone methyltransferase SMYD2-mediated protein methylation

(2013) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

(2012) Glenn S. Van Aller et al.   Epigenetics

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

(2012) Joshua D. Stender et al.   MOLECULAR CELL

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Biochemical Characterization of Human SET and MYND Domain-Containing Protein 2 Methyltransferase

(2011) Jiaquan Wu et al.   BIOCHEMISTRY

Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation

(2011) Li Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Histone and p53 Methyltransferase SmyD2 Reveal a Conformational Flexibility of the Autoinhibitory C-Terminal Domain

(2011) Yuanyuan Jiang et al.   PLoS One

Structural Basis of Substrate Methylation and Inhibition of SMYD2

(2011) Andrew D. Ferguson et al.   STRUCTURE

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

(2011) Mohamed Abu-Farha et al.   Journal of Molecular Cell Biology

Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins

(2011) Shutong Xu et al.   Journal of Molecular Cell Biology

Methylation of the Retinoblastoma Tumor Suppressor by SMYD2

(2010) Louis A. Saddic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Deletion of Smyd2 Is Dispensable for Mouse Heart Development

(2010) Florian Diehl et al.   PLoS One

Identification of Smyd4 as a Potential Tumor Suppressor Gene Involved in Breast Cancer Development

(2009) L. Hu et al.   CANCER RESEARCH

Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma

(2009) Shuhei Komatsu et al.   CARCINOGENESIS

Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions

(2008) Britta Skawran et al.   MODERN PATHOLOGY