TLRs/NLRs: Shaping the landscape of host immunity

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK

(2017) Edina Schweighoffer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

(2017) Christian Lood et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy

(2017) Jian Ye et al.   JOURNAL OF IMMUNOLOGY

Activation and pathogenic manipulation of the sensors of the innate immune system

(2017) Charlotte Odendall et al.   MICROBES AND INFECTION

Innate Immune Receptors as Competitive Determinants of Cell Fate

(2017) Kate M. Franz et al.   MOLECULAR CELL

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses

(2016) Sihan Lv et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway

(2016) Yan Feng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Understanding the regulation of pattern recognition receptors in inflammatory diseases - a ‘Nod’ in the right direction

(2016) Claire L. Feerick et al.   IMMUNOLOGY

Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation

(2016) Peipei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors

(2016) Atul Udgata et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release

(2016) Juliang Qin et al.   JOURNAL OF IMMUNOLOGY

Brucella abortus down-regulates MHC class II by the IL-6-dependent inhibition of CIITA through the downmodulation of IFN regulatory factor-1 (IRF-1)

(2016) Lis N. Velásquez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Evasion and interference: intracellular pathogens modulate caspase-dependent inflammatory responses

(2016) Mary K. Stewart et al.   NATURE REVIEWS MICROBIOLOGY

Role of TLRs and DAMPs in allograft inflammation and transplant outcomes

(2016) Faouzi Braza et al.   Nature Reviews Nephrology

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

(2016) Raffaella Mastrocola et al.   Oxidative Medicine and Cellular Longevity

Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production

(2016) David Millrine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Autophagy Beyond Intracellular MHC Class II Antigen Presentation

(2016) Christian Münz   TRENDS IN IMMUNOLOGY

TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells

(2016) Xiaoli Li et al.   Scientific Reports

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

(2016) Hong Feng et al.   Journal of Diabetes Research

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes

(2016) Galaxia M. Rodriguez et al.   OncoImmunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Suppression of antigen presentation by IL-10

(2015) Sharad K Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Toll-like receptors: Activation, signalling and transcriptional modulation

(2015) Dominic De Nardo   CYTOKINE

Macrophage takeover and the host–bacilli interplay during tuberculosis

(2015) Khalid Hussain Bhat et al.   Future Microbiology

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

(2015) Lucia de Almeida et al.   IMMUNITY

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome

(2015) Qiuchan Deng et al.   INFECTION AND IMMUNITY

Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

(2015) Kongyang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

(2015) Rachel P. J. Lai et al.   Nature Communications

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression

(2015) Shui-Xing Yu et al.   Scientific Reports

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

NOD-like receptors interfacing the immune and reproductive systems

(2014) Hanne Van Gorp et al.   FEBS Journal

Toll-like receptors and B cells: functions and mechanisms

(2014) Claire M. Buchta et al.   IMMUNOLOGIC RESEARCH

The TLR and IL-1 signalling network at a glance

(2014) P. Cohen   JOURNAL OF CELL SCIENCE

Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease

(2014) C. J. Blohmke et al.   JOURNAL OF IMMUNOLOGY

TLR7 induces anergy in human CD4+ T cells

(2014) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

(2014) A. R. Mantegazza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspectives on host adaptation in response to Mycobacterium tuberculosis: Modulation of inflammation

(2014) Anca Dorhoi et al.   SEMINARS IN IMMUNOLOGY

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy

(2013) Yu Lei et al.   Autophagy

Leishmaniaexpressed lipophosphoglycan interacts with Toll-like receptor (TLR)-2 to decrease TLR-9 expression and reduce anti-leishmanial responses

(2013) S. Srivastava et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate receptors for adaptive immunity

(2013) Marie-Cécile Michallet et al.   CURRENT OPINION IN MICROBIOLOGY

Novel NLRP7 mutations in familial recurrent hydatidiform mole: are NLRP7 mutations a risk for recurrent reproductive wastage?

(2013) V. Ulker et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg:B cell co-cultures

(2013) Tomabu Adjobimey et al.   Innate Immunity

Endocytosis ofMycobacterium tuberculosisHeat Shock Protein 60 Is Required to Induce Interleukin-10 Production in Macrophages

(2013) Nazia Parveen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod1 and Nod2 Enhance TLR-Mediated Invariant NKT Cell Activation during Bacterial Infection

(2013) T. Selvanantham et al.   JOURNAL OF IMMUNOLOGY

Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection

(2013) M. T. R. Gomes et al.   JOURNAL OF IMMUNOLOGY

B Cell-Intrinsic TLR7 Signaling Is Required for Optimal B Cell Responses during Chronic Viral Infection

(2013) J. M. Clingan et al.   JOURNAL OF IMMUNOLOGY

Roles of NLRP10 in innate and adaptive immunity

(2013) Anna Damm et al.   MICROBES AND INFECTION

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor regulation of effector T lymphocyte function

(2013) Joseph M. Reynolds et al.   TRENDS IN IMMUNOLOGY

Long-Lasting T Cell-Independent IgG Responses Require MyD88-Mediated Pathways and Are Maintained by High Levels of Virus Persistence

(2013) F. M. Raval et al.   mBio

IRF-4-Mediated CIITA Transcription Is Blocked by KSHV Encoded LANA to Inhibit MHC II Presentation

(2013) Qiliang Cai et al.   PLoS Pathogens

Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases

(2013) Athina Savva et al.   Frontiers in Immunology

Evolving Bacterial Envelopes and Plasticity of TLR2-Dependent Responses: Basic Research and Translational Opportunities

(2013) Junbin Li et al.   Frontiers in Immunology

Toll-like Receptor 7 Is Required for Effective Adaptive Immune Responses that Prevent Persistent Virus Infection

(2012) Kevin B. Walsh et al.   Cell Host & Microbe

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

The Effects of TLR Activation on T-Cell Development and Differentiation

(2012) Bo Jin et al.   Clinical & Developmental Immunology

Recurrent hydatidiform mole: detection of two novel mutations in the NLRP7 gene in two Egyptian families

(2012) Ebtesam M. Abdalla et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Nitric Oxide Increases Susceptibility of Toll-like Receptor-Activated Macrophages to Spreading Listeria monocytogenes

(2012) Caroline Cole et al.   IMMUNITY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

Proline-Proline-Glutamic Acid (PPE) Protein Rv1168c ofMycobacterium tuberculosisAugments Transcription from HIV-1 Long Terminal Repeat Promoter

(2012) Khalid Hussain Bhat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy

(2012) Craig R. Homer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells

(2012) F. Staehli et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

(2012) A. Biswas et al.   JOURNAL OF IMMUNOLOGY

Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity

(2012) Guangwei Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

NOD1 Cooperates with TLR2 to Enhance T Cell Receptor-Mediated Activation in CD8 T Cells

(2012) Blandine C. Mercier et al.   PLoS One

Role of PPE18 Protein in Intracellular Survival and Pathogenicity of Mycobacterium tuberculosis in Mice

(2012) Khalid Hussain Bhat et al.   PLoS One

Chitohexaose Activates Macrophages by Alternate Pathway through TLR4 and Blocks Endotoxemia

(2012) Santosh K. Panda et al.   PLoS Pathogens

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

(2011) Joshua C. Cyktor et al.   INFECTION AND IMMUNITY

TLR2 and RIP2 Pathways Mediate Autophagy ofListeria monocytogenesvia Extracellular Signal-regulated Kinase (ERK) Activation

(2011) Paras K. Anand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PPE18 Protein of Mycobacterium tuberculosis Inhibits NF- B/rel-Mediated Proinflammatory Cytokine Production by Upregulating and Phosphorylating Suppressor of Cytokine Signaling 3 Protein

(2011) S. Nair et al.   JOURNAL OF IMMUNOLOGY

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

(2011) N. Jounai et al.   JOURNAL OF IMMUNOLOGY

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

(2011) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Anthrax and the inflammasome

(2011) Mahtab Moayeri et al.   MICROBES AND INFECTION

Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda

(2011) A J Griffin et al.   Mucosal Immunology

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

NLR identity theft

(2011) Cesar Sanchez   NATURE REVIEWS MICROBIOLOGY

TLR2 Signaling Contributes to Rapid Inflammasome Activation during F. novicida Infection

(2011) Crystal L. Jones et al.   PLoS One

The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation

(2011) Michael H. Shaw et al.   TRENDS IN IMMUNOLOGY

IL-10 Blocks Phagosome Maturation inMycobacterium tuberculosis–Infected Human Macrophages

(2010) Seónadh O'Leary et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nod proteins link bacterial sensing and autophagy

(2010) Leonardo H. Travassos et al.   Autophagy

The Inflammasomes

(2010) Kate Schroder et al.   CELL

What is new with Nods?

(2010) Joao G Magalhaes et al.   CURRENT OPINION IN IMMUNOLOGY

IL-1: Discoveries, controversies and future directions

(2010) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease

(2010) Joseph M. Reynolds et al.   IMMUNITY

Mycobacterium tuberculosisLipoproteins Directly Regulate Human Memory CD4+T Cell Activation via Toll-Like Receptors 1 and 2

(2010) Christina L. Lancioni et al.   INFECTION AND IMMUNITY

Pore Formation Triggered by Legionella spp. Is an Nlrc4 Inflammasome-Dependent Host Cell Response That Precedes Pyroptosis

(2010) T. N. Silveira et al.   INFECTION AND IMMUNITY

IL-10 Inhibits miR-155 Induction by Toll-like Receptors

(2010) Claire E. McCoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1

(2010) H.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

The Pathogen Recognition Receptor NOD2 Regulates Human FOXP3+ T Cell Survival

(2010) M. K. Rahman et al.   JOURNAL OF IMMUNOLOGY

PE_PGRS Antigens of Mycobacterium tuberculosis Induce Maturation and Activation of Human Dendritic Cells

(2010) K. Bansal et al.   JOURNAL OF IMMUNOLOGY

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors

(2010) Terese Petterson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

(2010) Federica Capolunghi et al.   RHEUMATOLOGY

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Toll-like receptors in control of immunological autophagy

(2009) M A Delgado et al.   CELL DEATH AND DIFFERENTIATION

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

NOD2 regulates hematopoietic cell function during graft-versus-host disease

(2009) Olaf Penack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal

(2009) B. C. Mercier et al.   JOURNAL OF IMMUNOLOGY

The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage

(2009) S. Nair et al.   JOURNAL OF IMMUNOLOGY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors

(2008) J M. Blander   ANNALS OF THE RHEUMATIC DISEASES

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

(2008) Chong-Shan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction

(2008) Elizabeth A. Misch et al.   PLoS Neglected Tropical Diseases