Understanding the regulation of pattern recognition receptors in inflammatory diseases - a ‘Nod’ in the right direction

Association between CARD8 rs2043211 Polymorphism and Inflammatory Bowel Disease: A Meta-Analysis

(2015) Juan Liu et al.   IMMUNOLOGICAL INVESTIGATIONS

Increased NOD1, but not NOD2, activity in subcutaneous adipose tissue from patients with metabolic syndrome

(2015) Yi-Jun Zhou et al.   Obesity

Expression and activity ofNOD1andNOD2/RIPK2signalling in mononuclear cells from patients with rheumatoid arthritis

(2015) RFO Franca et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

(2015) Nathalie Acevedo et al.   Clinical Epigenetics

The E3 Ligase RNF34 is a Novel Negative Regulator of the NOD1 Pathway

(2014) Rui Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

(2014) Deepshika Ramanan et al.   IMMUNITY

NOD2 Stimulation by Staphylococcus aureus-Derived Peptidoglycan Is Boosted by Toll-Like Receptor 2 Costimulation with Lipoproteins in Dendritic Cells

(2014) Holger Schäffler et al.   INFECTION AND IMMUNITY

Identification of hypo- and hypermethylated genes related to atherosclerosis by a genome-wide analysis of DNA methylation

(2014) YOSHIJI YAMADA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease

(2014) Vishnu Mohanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD1 expression is increased in the adipose tissue of women with gestational diabetes

(2014) Martha Lappas   JOURNAL OF ENDOCRINOLOGY

Blau Syndrome–AssociatedNod2Mutation Alters Expression of Full-Length NOD2 and Limits Responses to Muramyl Dipeptide in Knock-in Mice

(2014) Jae Dugan et al.   JOURNAL OF IMMUNOLOGY

Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis inApoe−/−Mice

(2014) Shunsuke Kanno et al.   JOURNAL OF IMMUNOLOGY

ATG16L1andNOD2polymorphisms enhance phagocytosis in monocytes of Crohn’s disease patients

(2014) Simone CS Wolfkamp   WORLD JOURNAL OF GASTROENTEROLOGY

Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

(2014) Georgina L Hold   WORLD JOURNAL OF GASTROENTEROLOGY

The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases

(2014) Caroline Marcantonio Ferreira et al.   Journal of Immunology Research

NOD2-Mediated Innate Immune Signaling Regulates the Eicosanoids in Atherosclerosis

(2013) Hui-Qing Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PSMA7 Directly Interacts with NOD1 and Regulates its Function

(2013) Liuzhong Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CARD8gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation

(2013) Geena Varghese Paramel et al.   CLINICAL SCIENCE

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

(2013) Matthew T. Sorbara et al.   IMMUNITY

Alarmins, inflammasomes and immunity

(2013) DavidM Ojcius et al.   Biomedical Journal

Autophagy and Intestinal Homeostasis

(2012) Khushbu K. Patel et al.   Annual Review of Physiology

Diversity and distribution of sulphate-reducing bacteria in human faeces from healthy subjects and patients with inflammatory bowel disease

(2012) Wenjing Jia et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The Nucleotide Synthesis Enzyme CAD Inhibits NOD2 Antibacterial Function in Human Intestinal Epithelial Cells

(2012) Amy L. Richmond et al.   GASTROENTEROLOGY

Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components

(2012) Kyoung-Hee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD2 is highly expressed in Behçet disease with pulmonary manifestations

(2012) Kamel Hamzaoui et al.   Journal of Inflammation-London

TRIM27 Negatively Regulates NOD2 by Ubiquitination and Proteasomal Degradation

(2012) Birte Zurek et al.   PLoS One

Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders

(2012) Zacharoula Konsoula et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes

(2011) Ling Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nod1 Ligands Induce Site-Specific Vascular Inflammation

(2011) Hisanori Nishio et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The pattern-recognition receptor nucleotide-binding oligomerization domain-containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts

(2011) Kazuhiro Yokota et al.   ARTHRITIS AND RHEUMATISM

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

(2011) S L Musone et al.   GENES AND IMMUNITY

DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts

(2011) E Karouzakis et al.   GENES AND IMMUNITY

Nod2 is essential for temporal development of intestinal microbial communities

(2011) A. Rehman et al.   GUT

Genome-Wide Expression Profiling Identifies an Impairment of Negative Feedback Signals in the Crohn’s Disease-Associated NOD2 Variant L1007fsinsC

(2011) Susanne Billmann-Born et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Crohn's Disease-Associated Nod2 Mutation Limits Production of Proinflammatory Cytokines To Protect the Host from Enterococcus faecalis-Induced Lethality

(2011) Y.-G. Kim et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Primary Innate Immune Cells Respond Efficiently to Polymeric Peptidoglycan, but Not to Peptidoglycan Monomers

(2011) Janaki K. Iyer et al.   JOURNAL OF IMMUNOLOGY

Nod2: a key regulator linking microbiota to intestinal mucosal immunity

(2011) Amlan Biswas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?

(2010) J. Bogefors et al.   ALLERGY

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Caspase Recruitment Domain-containing Protein 8 (CARD8) Negatively Regulates NOD2-mediated Signaling

(2010) Oliver von Kampen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts

(2009) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan

(2009) Chung-Hang Leung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling

(2009) Jooeun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

(2008) Michael H Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Reduced  -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease

(2008) L A Simms et al.   GUT

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Signature biomarkers in Crohn's disease: toward a molecular classification

(2008) R Arsenescu et al.   Mucosal Immunology

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

The Nod-Like Receptor (NLR) Family: A Tale of Similarities and Differences

(2008) Martina Proell et al.   PLoS One

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA