Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

(2016) Sahar Emran et al.   Aging-US

Effect of Two Different Weight-Loss Rates on Body Composition and Strength and Power-Related Performance in Elite Athletes

(2016) Ina Garthe et al.   INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM

Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence

(2014) Duc Tran et al.   AGING CELL

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

(2014) D. Lee Hamilton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle

(2014) D. J. Player et al.   BIOTECHNOLOGY LETTERS

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Resveratrol prevents TNF-α-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes

(2014) Dong-Tao Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation

(2014) Sungki Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

(2014) A. W. Beharry et al.   JOURNAL OF CELL SCIENCE

Dietary restriction and the pursuit of effective mimetics

(2014) Colin Selman   PROCEEDINGS OF THE NUTRITION SOCIETY

Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice

(2014) Raghu Sinha et al.   PROSTATE

A Brief Review of Critical Processes in Exercise-Induced Muscular Hypertrophy

(2014) Stuart M. Phillips   SPORTS MEDICINE

Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging

(2014) Nazif Alic et al.   Cell Reports

Reductions in serum IGF-1 during aging impair health span

(2013) Zhenwei Gong et al.   AGING CELL

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

SIRT1 and SIRT2: emerging targets in neurodegeneration

(2013) Gizem Donmez et al.   EMBO Molecular Medicine

Mechanisms regulating skeletal muscle growth and atrophy

(2013) Stefano Schiaffino et al.   FEBS Journal

The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy

(2013) Adam P. Sharples et al.   GROWTH HORMONE & IGF RESEARCH

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 silencing confers neuroprotection through IGF-1 pathway activation

(2013) Luigi Sansone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

(2013) Brittany L. Jacobs et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impaired hypertrophy in myoblasts is improved with testosterone administration

(2013) Colleen S. Deane et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise

(2013) Bong-Sup Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

1,25(OH)2-vitamin D3enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes

(2013) Jérôme Salles et al.   MOLECULAR NUTRITION & FOOD RESEARCH

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Nutritional strategies to attenuate muscle disuse atrophy

(2013) Benjamin T Wall et al.   NUTRITION REVIEWS

Preserving Youth: Does Rapamycin Deliver?

(2013) S. C. Johnson et al.   Science Translational Medicine

Gene expression analysis of mTOR pathway: association with human longevity

(2012) Willemijn M. Passtoors et al.   AGING CELL

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis

(2012) Naomi M Cermak et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial

(2012) Russell J de Souza et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

Protein ingestion does not impair exercise-induced AMPK signalling when in a glycogen-depleted state: implications for train-low compete-high

(2012) Conor Taylor et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men

(2012) Tyler A. Churchward-Venne et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan

(2011) John R. Speakman et al.   BIOESSAYS

Genetic Reduction of Insulin-like Growth Factor-1 Mimics the Anticancer Effects of Calorie Restriction on Cyclooxygenase-2–Driven Pancreatic Neoplasia

(2011) Laura M. Lashinger et al.   Cancer Prevention Research

Myoblast models of skeletal muscle hypertrophy and atrophy

(2011) Adam P Sharples et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys

(2011) Susan H. McKiernan et al.   EXPERIMENTAL GERONTOLOGY

Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol

(2011) Amarjit Saini et al.   EXPERIMENTAL PHYSIOLOGY

Reduction of myoblast differentiation following multiple population doublings in mouse C2C12 cells: A model to investigate ageing?

(2011) Adam P. Sharples et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3

(2011) Nasser Al-Shanti et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Increased Consumption of Dairy Foods and Protein during Diet- and Exercise-Induced Weight Loss Promotes Fat Mass Loss and Lean Mass Gain in Overweight and Obese Premenopausal Women

(2011) Andrea R. Josse et al.   JOURNAL OF NUTRITION

The role of skeletal muscle mTOR in the regulation of mechanical load-induced growth

(2011) Craig A. Goodman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling

(2011) Mitsunori Miyazaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle

(2011) M. Hidestrand et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Effects of a Higher Protein Intake During Energy Restriction on Changes in Body Composition and Physical Function in Older Women

(2011) M. C. Mojtahedi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

NF-κB Negatively Impacts the Myogenic Potential of Muscle-derived Stem Cells

(2011) Aiping Lu et al.   MOLECULAR THERAPY

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway

(2011) Gustavo D Pimentel et al.   Nutrition & Metabolism

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

(2011) Colin Selman et al.   PLoS One

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Human muscle satellite cells show age-related differential expression of S100B protein and RAGE

(2010) Sara Beccafico et al.   AGE

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

C2 Skeletal Myoblast Survival, Death, Proliferation and Differentiation: Regulation by Adra1d

(2010) Amarjit Saini et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle

(2010) Susan H. McKiernan et al.   EXPERIMENTAL GERONTOLOGY

Aging and cancer: are sirtuins the link?

(2010) Ramon M Rodriguez et al.   Future Oncology

Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

(2010) Andrew Philp et al.   JOURNAL OF APPLIED PHYSIOLOGY

Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTOR

(2010) Meilian Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: Relevance to disease and ageing?

(2010) Adam P. Sharples et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

(2010) M. D. W. Piper et al.   JOURNAL OF INTERNAL MEDICINE

Anabolic and Catabolic Hormones and Energy Balance of the Male Bodybuilders During the Preparation for the Competition

(2010) Jarek Mäestu et al.   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mammalian models of extended healthy lifespan

(2010) C. Selman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genomics of human longevity

(2010) P. E. Slagboom et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells

(2009) Philip J. Atherton et al.   AMINO ACIDS

Differentiation rather than aging of muscle stem cells abolishes their telomerase activity

(2009) Matthew S. O'Connor et al.   BIOTECHNOLOGY PROGRESS

Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research

(2009) S. D. Hursting et al.   CARCINOGENESIS

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1

(2009) Mark Willett et al.   CELLULAR SIGNALLING

Understanding sarcopenia as a geriatric syndrome

(2009) Alfonso J Cruz-Jentoft et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

(2009) Tiziana Pietrangelo et al.   EXPERIMENTAL GERONTOLOGY

Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: Enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism

(2009) Melissa M. Page et al.   FREE RADICAL BIOLOGY AND MEDICINE

POINT: IGF IS THE MAJOR PHYSIOLOGICAL REGULATOR OF MUSCLE MASS

(2009) C. E. Stewart et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

(2009) Micah J. Drummond et al.   JOURNAL OF PHYSIOLOGY-LONDON

Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity

(2009) M. M. Masternak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

(2009) George A. Garinis et al.   NATURE CELL BIOLOGY

Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

(2009) Frank M. Sacks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A

(2009) A. N. Vallejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men

(2008) Daniel R Moore et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia

(2008) Russell T. Hepple et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

Replicative aging down-regulates the myogenic regulatory factors in human myoblasts

(2008) Anne Bigot et al.   BIOLOGY OF THE CELL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Sirt1 increases skeletal muscle precursor cell proliferation

(2008) Christopher R. Rathbone et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Serum IGF-I-Deficiency Does Not Prevent Compensatory Skeletal Muscle Hypertrophy in Resistance Exercise

(2008) Wayne Matheny et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pro- and anti-apoptotic roles for IGF-I in TNF-α-induced apoptosis: A MAP kinase mediated mechanism

(2008) Amarjit Saini et al.   GROWTH FACTORS

Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

(2008) Vinod Kumar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues

(2008) Ana Maria Garcia et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Signaling in Muscle Atrophy and Hypertrophy

(2008) Marco Sandri   PHYSIOLOGY

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL