Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

RAG GTPases in nutrient-mediated TOR signaling pathway

(2011) Eunjung Kim et al.   CELL CYCLE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

High-frequency electrically stimulated skeletal muscle contractions increase p70s6kphosphorylation independent of known IGF-I sensitive signaling pathways

(2010) Sarah Witkowski et al.   FEBS LETTERS

COUNTERPOINT: IGF IS NOT THE MAJOR PHYSIOLOGICAL REGULATOR OF MUSCLE MASS

(2010) Martin Flueck et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis

(2010) Yuting Sun et al.   JOURNAL OF CELL BIOLOGY

Impaired muscle regeneration and myoblast differentiation in mice with a muscle-specific KO of IGF-IR

(2010) Lisa Heron-Milhavet et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy

(2010) Craig A. Goodman et al.   MOLECULAR BIOLOGY OF THE CELL

A Limited Role for PI(3,4,5)P3 Regulation in Controlling Skeletal Muscle Mass in Response to Resistance Exercise

(2010) D. Lee Hamilton et al.   PLoS One

Relation between extent of myostatin depletion and muscle growth in mature mice

(2009) Stephen Welle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice

(2009) Stephen Welle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The signaling underlying FITnessThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) Keith Baar   Applied Physiology Nutrition and Metabolism

POINT: IGF IS THE MAJOR PHYSIOLOGICAL REGULATOR OF MUSCLE MASS

(2009) C. E. Stewart et al.   JOURNAL OF APPLIED PHYSIOLOGY

Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors

(2009) Daniel W. D. West et al.   JOURNAL OF APPLIED PHYSIOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

(2009) T. K. O’Neil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men

(2009) Daniel W. D. West et al.   JOURNAL OF PHYSIOLOGY-LONDON

Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids

(2008) Micah J. Drummond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

(2008) Adel Amirouche et al.   ENDOCRINOLOGY

Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise

(2008) Louise Deldicque et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

The effect of amino acid infusion on leg protein turnover assessed by L-[15N]phenylalanine and L-[1-13C]leucine exchange

(2008) W. M. BENNET et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

(2008) Vinod Kumar et al.   JOURNAL OF PHYSIOLOGY-LONDON

mVps34 is activated following high-resistance contractions

(2008) Matthew G. MacKenzie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Signaling in Muscle Atrophy and Hypertrophy

(2008) Marco Sandri   PHYSIOLOGY

Phospholipase D1 is an effector of Rheb in the mTOR pathway

(2008) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy

(2007) Espen E. Spangenburg et al.   JOURNAL OF PHYSIOLOGY-LONDON