Rapamycin Extends Life and Health in C57BL/6 Mice

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Cardiac mTOR protects the heart against ischemia-reperfusion injury

(2012) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

(2012) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Sirolimus and its Analogs and its Effects on Vascular Diseases

(2011) Steven J. Adelman   CURRENT PHARMACEUTICAL DESIGN

Mammalian Target of Rapamycin Complex 1 Activation Is Required for the Stimulation of Human Skeletal Muscle Protein Synthesis by Essential Amino Acids

(2011) Jared M. Dickinson et al.   JOURNAL OF NUTRITION

Combination therapy in metastatic renal cell carcinoma

(2011) Daniel YC Heng   LANCET ONCOLOGY

Interpreting Mammalian Target of Rapamycin and Cell Growth Inhibition in a Genetically Engineered Mouse Model of Nf1-Deficient Astrocytes

(2011) S. Banerjee et al.   MOLECULAR CANCER THERAPEUTICS

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

(2010) Subhash D. Katewa et al.   EXPERIMENTAL GERONTOLOGY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

(2009) Pascal Colosetti et al.   Autophagy

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Effect of Low-Dose Rapamycin on Tumor Growth in Two Human Hepatocellular Cancer Cell Lines

(2009) M. Heuer et al.   TRANSPLANTATION PROCEEDINGS

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL