Reductions in serum IGF-1 during aging impair health span

Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone

(2013) Johanna G. Miquet et al.   CELL CYCLE

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

(2013) Andrzej Bartke et al.   PHYSIOLOGICAL REVIEWS

Caloric restriction may reverse age-related autonomic decline in humans

(2012) Phyllis K. Stein et al.   AGING CELL

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1

(2012) Yusuke Higashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies

(2012) W. E. Sonntag et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

(2011) Myunggi Baik et al.   Annals of the New York Academy of Sciences

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice

(2011) Kristina M. Mueller et al.   HEPATOLOGY

Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging

(2011) L. C. Bailey-Downs et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner

(2011) Hayden-William Courtland et al.   PLoS One

Liver-Derived IGF-I Regulates Mean Life Span in Mice

(2011) Johan Svensson et al.   PLoS One

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Insulin-Like Growth Factor-I Regulates the Liver Microenvironment in Obese Mice and Promotes Liver Metastasis

(2010) Y. Wu et al.   CANCER RESEARCH

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1

(2010) Sebastien Elis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact

(2010) Sebastien Elis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: Enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism

(2009) Melissa M. Page et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

(2009) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL