Gene expression analysis of mTOR pathway: association with human longevity

Human insulin/IGF-1 and familial longevity at middle age

(2016) Maarten P. Rozing et al.   Aging-US

Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R

(2012) Willemijn M. Passtoors et al.   PLoS One

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

(2011) Joris Deelen et al.   AGING CELL

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation

(2011) Zi Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Familial longevity is marked by enhanced insulin sensitivity

(2010) Carolien A. Wijsman et al.   AGING CELL

Hallmark Features of Immunosenescence Are Absent in Familial Longevity

(2010) E. Derhovanessian et al.   JOURNAL OF IMMUNOLOGY

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study

(2010) Maarten P. Rozing et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study

(2009) Rudi G.J. Westendorp et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work?

(2008) C Le Tourneau et al.   BRITISH JOURNAL OF CANCER

Pancreatic cancer: from molecular pathogenesis to targeted therapy

(2008) Alexios Strimpakos et al.   CANCER AND METASTASIS REVIEWS

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people

(2008) Sven Koch et al.   Immunity & Ageing