Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin β4-Mediated FAK Signaling
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin β4-Mediated FAK Signaling
Authors
Keywords
Hedgehog signaling, Ovarian cancer, Cancer cell migration, Cancer treatment, Gene expression, Phosphorylation, Cell motility, Polymerase chain reaction
Journal
PLoS One
Volume 9, Issue 2, Pages e88386
Publisher
Public Library of Science (PLoS)
Online
2014-02-13
DOI
10.1371/journal.pone.0088386
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
- (2013) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft
- (2012) Junsheng Fu et al. CANCER LETTERS
- Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer
- (2012) Jing-Song Chen et al. CARCINOGENESIS
- Role of α6β4 Integrin in Cell Motility, Invasion and Metastasis of Mammary Tumors
- (2012) Jun Chung et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis
- (2012) Z. J. Li et al. DEVELOPMENT
- New biomarkers and targets in pancreatic cancer and their application to treatment
- (2012) Eithne Costello et al. Nature Reviews Gastroenterology & Hepatology
- High-grade serous ovarian cancer arises from fallopian tube in a mouse model
- (2012) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines
- (2011) V. Swaminathan et al. CANCER RESEARCH
- Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
- (2011) P. M. LoRusso et al. CLINICAL CANCER RESEARCH
- Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
- (2011) Xin Pan et al. NATURE MEDICINE
- Ovarian Cancer Development and Metastasis
- (2010) Ernst Lengyel AMERICAN JOURNAL OF PATHOLOGY
- Important role of integrins in the cancer biology
- (2010) R. Rathinam et al. CANCER AND METASTASIS REVIEWS
- Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells
- (2010) T. Mazumdar et al. CANCER RESEARCH
- TGF- Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling
- (2010) R. W. Johnson et al. CANCER RESEARCH
- FAK is involved in invasion and metastasis of hepatocellular carcinoma
- (2010) Jing-Song Chen et al. CLINICAL & EXPERIMENTAL METASTASIS
- Signal transduction by focal adhesion kinase in cancer
- (2009) Jihe Zhao et al. CANCER AND METASTASIS REVIEWS
- Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation
- (2009) Y. Katoh et al. CURRENT MOLECULAR MEDICINE
- Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2
- (2009) Shi-Wen Luo et al. EMBO JOURNAL
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
- (2009) Keefe T. Chan et al. JOURNAL OF CELL BIOLOGY
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
- (2009) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
- (2009) Suzie J. Scales et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation
- (2008) Shuntaro Nagai et al. CANCER SCIENCE
- Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
- (2008) Xiaoyun Liao et al. CARCINOGENESIS
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
- HSP90β Regulates Rapsyn Turnover and Subsequent AChR Cluster Formation and Maintenance
- (2008) Shiwen Luo et al. NEURON
- Hedgehog signaling pathway: Development of antagonists for cancer therapy
- (2008) Jingwu Xie Current Oncology Reports
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now