Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer

(2014) Jillian Brechbiel et al.   CANCER TREATMENT REVIEWS

Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas

(2014) Dongsheng Yue et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis

(2013) V Damiano et al.   BRITISH JOURNAL OF CANCER

mTOR inhibitors in advanced renal cell carcinomas: From biology to clinical practice

(2013) Philippe Barthélémy et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition

(2013) Shamik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

(2013) Mariella Gruber Filbin et al.   NATURE MEDICINE

Microenvironmental Regulation of Epithelial-Mesenchymal Transitions in Cancer

(2012) D. Gao et al.   CANCER RESEARCH

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

(2012) R. McMillan et al.   CLINICAL CANCER RESEARCH

Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

(2012) R. Rosa et al.   CLINICAL CANCER RESEARCH

Cytometric and biochemical characterization of human breast cancer cells reveals heterogeneous myoepithelial phenotypes

(2012) Felicia Leccia et al.   CYTOMETRY PART A

Smoothened Antagonists Reverse Taxane Resistance in Ovarian Cancer

(2012) A. D. Steg et al.   MOLECULAR CANCER THERAPEUTICS

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Schisandrin B Attenuates Cancer Invasion and Metastasis Via Inhibiting Epithelial-Mesenchymal Transition

(2012) Zhen Liu et al.   PLoS One

Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody

(2012) Francesca Monteleone et al.   PROTEOMICS

Hedgehog Inhibition With the Orally Bioavailable Smo Antagonist LDE225 Represses Tumor Growth and Prolongs Survival in a Transgenic Mouse Model of Islet Cell Neoplasms

(2011) Volker Fendrich et al.   ANNALS OF SURGERY

Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

(2011) E. Heller et al.   CANCER RESEARCH

Targeting the hedgehog signaling pathway with interacting peptides to Patched-1

(2011) Masafumi Nakamura et al.   JOURNAL OF GASTROENTEROLOGY

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells

(2011) X Cao et al.   ONCOGENE

Tumor Biology and Prognostic Factors in Renal Cell Carcinoma

(2011) D. S. Finley et al.   ONCOLOGIST

Up-Regulation of Sonic Hedgehog Contributes to TGF-β1-Induced Epithelial to Mesenchymal Transition in NSCLC Cells

(2011) Ma'in Y. Maitah et al.   PLoS One

Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression

(2011) Liang Zhang et al.   PLoS One

Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells

(2011) Katsumi Shigemura et al.   PROSTATE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma

(2010) D. Huang et al.   CANCER RESEARCH

Sunitinib Acts Primarily on Tumor Endothelium rather than Tumor Cells to Inhibit the Growth of Renal Cell Carcinoma

(2010) D. Huang et al.   CANCER RESEARCH

Long-term cultures of stem/progenitor cells from lobular and ductal breast carcinomas under non-adherent conditions

(2010) Agostina Nardone et al.   CYTOTECHNOLOGY

GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin

(2010) S Inaguma et al.   ONCOGENE

Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer

(2009) Maria–Theresa Mueller et al.   GASTROENTEROLOGY

Hedgehog Signaling Regulates the Survival of Gastric Cancer Cells by Regulating the Expression of Bcl-2

(2009) Myoung-Eun Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resistance to targeted therapy in renal-cell carcinoma

(2009) Brian I Rini et al.   LANCET ONCOLOGY

The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth

(2009) Valérian Dormoy et al.   Molecular Cancer

Neuropilin-1 Upholds Dedifferentiation and Propagation Phenotypes of Renal Cell Carcinoma Cells by Activating Akt and Sonic Hedgehog Axes

(2008) Ying Cao et al.   CANCER RESEARCH

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse

(2008) Robert J. Lipinski et al.   TOXICOLOGICAL SCIENCES