Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells

Inhibition of Hedgehog/Gli Signaling by Botanicals: A Review of Compounds with Potential Hedgehog Pathway Inhibitory Activities

(2013) Sara Drenkhahn et al.   CURRENT CANCER DRUG TARGETS

Pax6 expressed in osteocytes inhibits canonical Wnt signaling

(2013) Ajita Jami et al.   MOLECULES AND CELLS

Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation

(2013) Shunsuke Nakamura et al.   PLoS One

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

(2012) Jeong In Yun et al.   ARCHIVES OF PHARMACAL RESEARCH

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

(2012) R. McMillan et al.   CLINICAL CANCER RESEARCH

Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors

(2012) Karla C.S. Queiroz et al.   DRUG RESISTANCE UPDATES

The activities of Smad and Gli mediated signalling pathways in high-grade conventional osteosarcoma

(2012) Alexander B. Mohseny et al.   EUROPEAN JOURNAL OF CANCER

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growthin vitroandin vivo

(2012) Malin Wickström et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting hedgehog-GLI-2 pathway in osteosarcoma

(2012) Wen Yang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma

(2012) Malcolm A. Smith et al.   PEDIATRIC BLOOD & CANCER

Genomic Instability and Telomere Fusion of Canine Osteosarcoma Cells

(2012) Junko Maeda et al.   PLoS One

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

(2012) Andrea Y. Angstadt et al.   Cancer Genetics

Cellular and Phenotypic Characterization of Canine Osteosarcoma Cell Lines

(2012) Marie E. Legare et al.   Journal of Cancer

Role of GLI2 in the growth of human osteosarcoma

(2011) Hiroko Nagao et al.   JOURNAL OF PATHOLOGY

Of dogs and men: Comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma

(2011) Kenneth S. Rankin et al.   PEDIATRIC BLOOD & CANCER

Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome

(2010) Liza E O'Donoghue et al.   BMC CANCER

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma

(2010) Mehdi H Shahi et al.   BMC CANCER

Smoothened as a new therapeutic target for human osteosarcoma

(2010) Masataka Hirotsu et al.   Molecular Cancer

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

(2009) Melissa Paoloni et al.   BMC GENOMICS

Hedgehog signalling: Emerging evidence for non-canonical pathways

(2009) Dagan Jenkins   CELLULAR SIGNALLING

Establishment of a Dog Model for the p53 Family Pathway and Identification of a Novel Isoform of p21 Cyclin-Dependent Kinase Inhibitor

(2009) Jin Zhang et al.   MOLECULAR CANCER RESEARCH