TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling

Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer

(2013) E. S. Antonarakis et al.   ONCOLOGIST

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

(2012) Jeong In Yun et al.   ARCHIVES OF PHARMACAL RESEARCH

Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth

(2012) Maribella Domenech et al.   Integrative Biology

Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma

(2012) Chad M. McKee et al.   JOURNAL OF CLINICAL INVESTIGATION

Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study

(2012) Karim Fizazi et al.   LANCET ONCOLOGY

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

(2011) E. Heller et al.   CANCER RESEARCH

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells

(2011) Mengqian Chen et al.   CELL CYCLE

Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling

(2011) Vassiliki Tzelepi et al.   HISTOPATHOLOGY

Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells

(2011) Nanor Sirab et al.   INTERNATIONAL JOURNAL OF CANCER

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

(2011) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells

(2011) Katsumi Shigemura et al.   PROSTATE

Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer

(2010) A. Slusarz et al.   CANCER RESEARCH

Review: Targeting the Hedgehog pathway in cancer

(2010) Sachin Gupta et al.   Therapeutic Advances in Medical Oncology

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

(2009) Martin R Tremblay et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts

(2009) A Shaw et al.   ONCOGENE

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo)

(2008) Xiaomei Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

(2008) Greg Shaw et al.   Cancer Cell International

GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer

(2008) S. Narita et al.   CLINICAL CANCER RESEARCH

Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression

(2008) S Azoulay et al.   JOURNAL OF PATHOLOGY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE