Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma

Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma

(2014) Daniel J. Kim et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy

(2014) Don L. Gibbons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists

(2013) James Kim et al.   CANCER CELL

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas

(2013) Fabio Bozzi et al.   LABORATORY INVESTIGATION

Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

(2013) Elena Conca et al.   Molecular Oncology

Through the open door: Preferential binding of dasatinib to the active form of BCR-ABL unveiled by in silico experiments

(2013) Erik Laurini et al.   Molecular Oncology

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

(2013) Scott X. Atwood et al.   NATURE

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

(2012) Markus Eberl et al.   EMBO Molecular Medicine

Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin

(2012) Eri Makinodan et al.   EXPERIMENTAL DERMATOLOGY

Trends in Basal Cell Carcinoma Incidence Rates: A 37-Year Dutch Observational Study

(2012) Sophie C. Flohil et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

LIPID11: A Modular Framework for Lipid Simulations Using Amber

(2012) Åge A. Skjevik et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted therapy in GIST: in silico modeling for prediction of resistance

(2011) Marco A. Pierotti et al.   Nature Reviews Clinical Oncology

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

(2010) Gerrit J. P. Dijkgraaf et al.   CANCER RESEARCH

Imatinib response in two GIST patients carrying two hitherto functionally uncharacterized PDGFRA mutations: An imaging, biochemical and molecular modeling study

(2010) Palma Dileo et al.   INTERNATIONAL JOURNAL OF CANCER

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE