Gli Proteins in Development and Disease

Patched1 Inhibits Epidermal Progenitor Cell Expansion and Basal Cell Carcinoma Formation by Limiting Igfbp2 Activity

(2010) R. M. Villani et al.   Cancer Prevention Research

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain

(2010) Vitor H Sousa et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

(2010) C. Wang et al.   DEVELOPMENT

Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

(2010) C. Cruz et al.   DEVELOPMENT

A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning

(2010) M. Lek et al.   DEVELOPMENT

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling

(2010) S. Raisin et al.   DEVELOPMENTAL BIOLOGY

Direct and indirect requirements of Shh/Gli signaling in early pituitary development

(2010) Yiwei Wang et al.   DEVELOPMENTAL BIOLOGY

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

(2010) V. Ribes et al.   GENES & DEVELOPMENT

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

Molecular analysis expands the spectrum of phenotypes associated with GLI3 mutations

(2010) Jennifer J. Johnston et al.   HUMAN MUTATION

Dual Function of UNC-51-like Kinase 3 (Ulk3) in the Sonic Hedgehog Signaling Pathway

(2010) Alla Maloverjan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity

(2010) Yannis E. Mavromatakis et al.   MECHANISMS OF DEVELOPMENT

Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

(2010) X. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS

(2010) Matthias Lauth et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMOylation by Pias1 Regulates the Activity of the Hedgehog Dependent Gli Transcription Factors

(2010) Barny Cox et al.   PLoS One

Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

(2010) E. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinctive Expression Patterns of Hedgehog Pathway Genes in theCiona intestinalisLarva: Implications for a Role of Hedgehog Signaling in Postembryonic Development and Chordate Evolution

(2010) A. F. M. Tariqul Islam et al.   ZOOLOGICAL SCIENCE

Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals

(2010) B. Stecca et al.   Journal of Molecular Cell Biology

Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development

(2010) Antonella Galli et al.   PLoS Genetics

Sufu recruits GSK3β for efficient processing of Gli3

(2009) Yoshiaki Kise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SUMO association with repressor complexes, emerging routes for transcriptional control

(2009) Mario Garcia-Dominguez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

(2009) Harald Schnidar et al.   CANCER RESEARCH

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud

(2009) Patrick Hill et al.   DEVELOPMENTAL BIOLOGY

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

(2009) Jinping Jia et al.   DEVELOPMENTAL BIOLOGY

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

(2009) Christopher W. Wilson et al.   NATURE

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase

(2009) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

(2009) L Yang et al.   ONCOGENE

Point Mutations in GLI3 Lead to Misregulation of its Subcellular Localization

(2009) Sybille Krauß et al.   PLoS One

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

(2009) Qing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Atoh1 Disrupts Sonic Hedgehog Signaling in the Developing Cerebellum and Prevents Medulloblastoma

(2009) A. Flora et al.   SCIENCE

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Vertebrate Limb Development: Moving from Classical Morphogen Gradients to an Integrated 4-Dimensional Patterning System

(2009) J.-D. Benazet et al.   Cold Spring Harbor Perspectives in Biology

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

SCL/TAL1 Interrupting Locus Derepresses GLI1 from the Negative Control of Suppressor-of-Fused in Pancreatic Cancer Cell

(2008) K. Kasai et al.   CANCER RESEARCH

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

(2008) Markku Varjosalo et al.   CELL

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

(2008) Yong Pan et al.   DEVELOPMENTAL BIOLOGY

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

(2008) Jianjian Zhu et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

(2008) S. A. Vokes et al.   GENES & DEVELOPMENT

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction

(2008) M. Evangelista et al.   Science Signaling

Gli2 Is a Novel Regulator of Sox2 Expression in Telencephalic Neuroepithelial Cells

(2008) Hiromi Takanaga et al.   STEM CELLS

Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment

(2007) Zhiyuan Ke et al.   MOLECULAR AND CELLULAR NEUROSCIENCE