Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling

(2016) Aiyada Aroonsri et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Identification of Plasmodium falciparum specific translation inhibitors from the MMV Malaria Box using a high throughput in vitro translation screen

(2016) Vida Ahyong et al.   MALARIA JOURNAL

Preliminary LC-MS Based Screening for Inhibitors of Plasmodium falciparum Thioredoxin Reductase (PfTrxR) among a Set of Antimalarials from the Malaria Box

(2016) Neil Tiwari et al.   MOLECULES

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

(2016) Gregory J. Crowther et al.   PLoS One

Yeast-Based High-Throughput Screens to Identify Novel Compounds Active against Brugia malayi

(2016) Elizabeth Bilsland et al.   PLoS Neglected Tropical Diseases

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

(2016) Britta Stadelmann et al.   PLoS Neglected Tropical Diseases

Activities ofN,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

(2015) Noemi Cowan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

(2015) María Linares et al.   MALARIA JOURNAL

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

(2015) Janette Reader et al.   MALARIA JOURNAL

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites

(2015) Mohamed Abdo Rizk et al.   PLoS One

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compounds

(2015) Leonardo Lucantoni et al.   Scientific Reports

Identification of β-hematin inhibitors in the MMV Malaria Box

(2015) Kim Y. Fong et al.   International Journal for Parasitology-Drugs and Drug Resistance

Plasmodium IspD (2-C-Methyl-d-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target

(2015) Leah S. Imlay et al.   ACS Infectious Diseases

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

(2015) Alessandro Paiardini et al.   PLoS One

Bilayer Effects of Antimalarial Compounds

(2015) Nicole B. Ramsey et al.   PLoS One

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

(2014) Erika L. Flannery et al.   ACS Chemical Biology

Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica

(2014) Fabrice F. Boyom et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

(2014) Wesley Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Male and Female Gametocyte Functional Viability Assay To Identify Biologically Relevant Malaria Transmission-Blocking Drugs

(2014) A. Ruecker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

(2014) K. Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1*

(2014) S. S. Kher et al.   Chemistry of Heterocyclic Compounds

Small Molecule Screen for Candidate Antimalarials TargetingPlasmodiumKinesin-5

(2014) Liqiong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

(2014) Sabine Fletcher et al.   MALARIA JOURNAL

Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

(2014) Vicky M Avery et al.   MALARIA JOURNAL

Diverse chemotypes disrupt ion homeostasis in the malaria parasite

(2014) Adele M. Lehane et al.   MOLECULAR MICROBIOLOGY

Gametocytocidal Screen Identifies Novel Chemical Classes with Plasmodium falciparum Transmission Blocking Activity

(2014) Natalie G. Sanders et al.   PLoS One

Identification of MMV Malaria Box Inhibitors of Perkinsus marinus Using an ATP-Based Bioluminescence Assay

(2014) Yesmalie Alemán Resto et al.   PLoS One

Evaluation of the inhibitory effects of miltefosine on the growth of Babesia and Theileria parasites

(2014) Mahmoud AbouLaila et al.   VETERINARY PARASITOLOGY

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

(2014) Akhil B. Vaidya et al.   Nature Communications

Chemical signatures and new drug targets for gametocytocidal drug development

(2014) Wei Sun et al.   Scientific Reports

Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box

(2014) Katrin Ingram-Sieber et al.   PLoS Neglected Tropical Diseases

Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy

(2013) Imke von Koschitzky et al.   AMINO ACIDS

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

(2013) Jessica D. Bowman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay

(2013) Leonardo Lucantoni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

(2013) Natalie J. Spillman et al.   Cell Host & Microbe

Identification of inhibitors of Plasmodium falciparum gametocyte development

(2013) Sandra Duffy et al.   MALARIA JOURNAL

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

(2013) MARK J. TAYLOR et al.   PARASITOLOGY

Inhibitory effect of allicin on the growth of Babesia and Theileria equi parasites

(2013) Akram Ahmed Salama et al.   PARASITOLOGY RESEARCH

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Prediction of the P. falciparum Target Space Relevant to Malaria Drug Discovery

(2013) Andreas Spitzmüller et al.   PLoS Computational Biology

Apicoplast-Targeting Antibacterials Inhibit the Growth of Babesia Parasites

(2012) Mahmoud AbouLaila et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector

(2012) J. C. van Pelt-Koops et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of in vitro and in vivo inhibitory effects of fusidic acid on Babesia and Theileria parasites

(2012) Akram Ahmed Salama et al.   VETERINARY PARASITOLOGY

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

(2011) Yo Suzuki et al.   NATURE METHODS

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

Role of hERG potassium channel assays in drug development

(2010) Birgit Priest et al.   Channels

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE