Prediction of the P. falciparum Target Space Relevant to Malaria Drug Discovery

Identification of Pim Kinases as Novel Targets for PJ34 with Confounding Effects in PARP Biology

(2012) Albert A. Antolín et al.   ACS Chemical Biology

Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries

(2012) Elisabeth Eckers et al.   BIOLOGICAL CHEMISTRY

Global Phenotypic Screening for Antimalarials

(2012) W. Armand Guiguemde et al.   CHEMISTRY & BIOLOGY

Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

(2012) Veronica M. Zhang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

(2012) Arnab K. Chatterjee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Identification of Small Molecule Inhibitors of Amyloid β-Induced Neuronal Apoptosis Acting through the Imidazoline I2 Receptor

(2012) Marisol Montolio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and functional deviations in disease-associated p97 mutants

(2012) Wai Kwan Tang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leads

(2012) Kasper Jensen et al.   Molecular BioSystems

Multi-Target Drugs: The Trend of Drug Research and Development

(2012) Jin-Jian Lu et al.   PLoS One

A Chemocentric Approach to the Identification of Cancer Targets

(2012) Beáta Flachner et al.   PLoS One

On the origins of drug polypharmacology

(2012) Xavier Jalencas et al.   MedChemComm

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines

(2011) Xiaoming Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Linking Pharmacology to Clinical Reports: Cyclobenzaprine and Its Possible Association With Serotonin Syndrome

(2011) J Mestres et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug-resistant malaria: Molecular mechanisms and implications for public health

(2011) Ines Petersen et al.   FEBS LETTERS

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

(2011) Mayura Meerang et al.   NATURE CELL BIOLOGY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase

(2010) Norbert Schormann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In silico directed chemical probing of the adenosine receptor family

(2010) Filipe M. Areias et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds

(2010) Gregory J. Crowther et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

In Silico Receptorome Screening of Antipsychotic Drugs

(2010) David Vidal et al.   Molecular Informatics

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

(2010) Joanna L. Sharman et al.   NUCLEIC ACIDS RESEARCH

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

The discovery of the potent aurora inhibitor MK-0457 (VX-680)

(2009) David Bebbington et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

(2009) Jordi Mestres et al.   Molecular BioSystems

A Novel Class of Small Molecule Inhibitors of Hsp90

(2008) Fang Yi et al.   ACS Chemical Biology

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Genomic-scale prioritization of drug targets: the TDR Targets database

(2008) Fernán Agüero et al.   NATURE REVIEWS DRUG DISCOVERY

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA