Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites

(2014) KATELYN R. KEYLOUN et al.   PARASITOLOGY

Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials

(2013) Natalie J. Spillman et al.   Cell Host & Microbe

Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii

(2013) Sebastian Lourido et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification

(2013) Mikhail M. Savitski et al.   JOURNAL OF PROTEOME RESEARCH

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Discovery and Biochemical Characterization of Plasmodium Thioredoxin Reductase Inhibitors from an Antimalarial Set

(2012) Andrew J. Theobald et al.   BIOCHEMISTRY

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

(2012) Zhongsheng Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Global Phenotypic Screening for Antimalarials

(2012) W. Armand Guiguemde et al.   CHEMISTRY & BIOLOGY

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

(2012) Kayode K. Ojo et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

(2012) Eric T. Larson et al.   JOURNAL OF MEDICINAL CHEMISTRY

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

(2012) Giovanna Bergamini et al.   Nature Chemical Biology

An evolutionary perspective on the kinome of malaria parasites

(2012) E. Talevich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Delayed Fragmentation and Optimized Isolation Width Settings for Improvement of Protein Identification and Accuracy of Isobaric Mass Tag Quantification on Orbitrap-Type Mass Spectrometers

(2011) Mikhail M. Savitski et al.   ANALYTICAL CHEMISTRY

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

A Research Agenda to Underpin Malaria Eradication

(2011) Pedro L. Alonso et al.   PLOS MEDICINE

The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission

(2010) Rita Tewari et al.   Cell Host & Microbe

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

(2010) Mikhail M. Savitski et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds

(2010) Gregory J. Crowther et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Use of thermal melt curves to assess the quality of enzyme preparations

(2009) Gregory J. Crowther et al.   ANALYTICAL BIOCHEMISTRY

Identification and Characterization of Novel Small Molecules as Potent Inhibitors of the Plasmodial Calcium-Dependent Protein Kinase 1

(2009) Guillaume Lemercier et al.   BIOCHEMISTRY

Malaria: Targeting parasite and host cell kinomes

(2009) Christian Doerig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Protein kinases as antibacterial targets

(2009) Mark Schreiber et al.   CURRENT OPINION IN CELL BIOLOGY

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

(2008) Nathalie Bouloc et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

(2008) Nobutaka Kato et al.   Nature Chemical Biology

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design

(2008) Anais Merckx et al.   STRUCTURE