Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

Working in concert: the metalloaminopeptidases from Plasmodium falciparum

(2013) Sheena McGowan   CURRENT OPINION IN STRUCTURAL BIOLOGY

Synthesis and Structure–Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum

(2013) Komagal Kannan Sivaraman et al.   JOURNAL OF MEDICINAL CHEMISTRY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria

(2012) Tina S. Skinner-Adams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL

(2012) Emanuele Bramucci et al.   BMC BIOINFORMATICS

Structure–Activity Relationships and Blood Distribution of Antiplasmodial Aminopeptidase-1 Inhibitors

(2012) Rebecca Deprez-Poulain et al.   JOURNAL OF MEDICINAL CHEMISTRY

X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP

(2012) Komagal Kannan Sivaraman et al.   JOURNAL OF MOLECULAR BIOLOGY

Distribution and Biochemical Properties of an M1-family Aminopeptidase inPlasmodium falciparumIndicate a Role in Vacuolar Hemoglobin Catabolism

(2011) Daniel Ragheb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase

(2011) Geetha Velmourougane et al.   JOURNAL OF MEDICINAL CHEMISTRY

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

(2011) M. B. Harbut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metallo-aminopeptidase inhibitors

(2010) Artur Mucha et al.   BIOCHIMIE

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

(2010) S. McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the inhibition of the essentialPlasmodium falciparumM1 neutral aminopeptidase

(2009) Sheena McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-Binding Groups Modulate Selective Inhibition of MMPs

(2008) Arpita Agrawal et al.   ChemMedChem