Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin

(2015) Tatiana Küster et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

(2015) Alessandro Paiardini et al.   PLoS One

Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica

(2014) Fabrice F. Boyom et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

(2014) K. Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Anthelmintic Drug Niclosamide Induces Apoptosis, Impairs Metastasis and Reduces Immunosuppressive Cells in Breast Cancer Model

(2014) Tinghong Ye et al.   PLoS One

Identification of MMV Malaria Box Inhibitors of Perkinsus marinus Using an ATP-Based Bioluminescence Assay

(2014) Yesmalie Alemán Resto et al.   PLoS One

The unique stem cell sysem of the immortal larva of the human parasite Echinococcus multilocularis

(2014) Uriel Koziol et al.   EvoDevo

Profound Activity of the Anti-cancer Drug Bortezomib against Echinococcus multilocularis Metacestodes Identifies the Proteasome as a Novel Drug Target for Cestodes

(2014) Britta Stadelmann et al.   PLoS Neglected Tropical Diseases

Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box

(2014) Katrin Ingram-Sieber et al.   PLoS Neglected Tropical Diseases

Repurposing drugs for the treatment and control of helminth infections

(2014) Gordana Panic et al.   International Journal for Parasitology-Drugs and Drug Resistance

In VitroandIn VivoActivities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes

(2013) Tatiana Küster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay

(2013) Leonardo Lucantoni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors

(2013) Sunghyun Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

The genome of the hydatid tapeworm Echinococcus granulosus

(2013) Huajun Zheng et al.   NATURE GENETICS

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Structure–activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling

(2012) Ill-Young Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Salicylanilide Inhibitors of Toxoplasma gondii

(2012) Alina Fomovska et al.   JOURNAL OF MEDICINAL CHEMISTRY

In VitroEfficacy of Dicationic Compounds and Mefloquine Enantiomers against Echinococcus multilocularis Metacestodes

(2011) Britta Stadelmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

The socioeconomic burden of parasitic zoonoses: Global trends

(2011) Paul R. Torgerson et al.   VETERINARY PARASITOLOGY

In VitroandIn VivoEfficacies of Mefloquine-Based Treatment against Alveolar Echinococcosis

(2010) Tatiana Küster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical features and treatment of alveolar echinococcosis

(2010) Peter Kern   CURRENT OPINION IN INFECTIOUS DISEASES

Echinococcus multilocularis phosphoglucose isomerase (EmPGI): A glycolytic enzyme involved in metacestode growth and parasite–host cell interactions

(2010) Britta Stadelmann et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes

(2010) B. Stadelmann et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Echinococcus multilocularis primary cells: Improved isolation, small-scale cultivation and RNA interference

(2010) Markus Spiliotis et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Gene silencing in Echinococcus multilocularis protoscoleces using RNA interference

(2010) Chiaki Mizukami et al.   PARASITOLOGY INTERNATIONAL

Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans

(2009) Enrico Brunetti et al.   ACTA TROPICA

Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes

(2009) A. HEMPHILL et al.   PARASITOLOGY

In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives

(2008) M. Spicher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY